Vitamin E: Regulatory role of metabolites

Long-chain metabolites of vitamin E: Interference with lipotoxicity via lipid droplet associated protein PLIN2

(2018) Lisa Schmölz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications

(2018) Marc Birringer et al.   RSC Advances

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

(2018) Helmut Pein et al.   Nature Communications

ω-Hydroxylation of α-tocopheryl quinone reveals a dual function for cytochrome P450-4F2 in vitamin E metabolism

(2018) Luke Taylor et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vitamin E: Emerging aspects and new directions

(2017) Francesco Galli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E

(2017) Lisa Schmölz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Determination of tocopherols and their metabolites by liquid-chromatography coupled with tandem mass spectrometry in human plasma and serum

(2017) Danilo Giusepponi et al.   TALANTA

Vitamin E metabolite 13′-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice

(2016) Yumi Jang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Analytical strategies to assess the functional metabolome of vitamin E

(2016) Pierangelo Torquato et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The long chain α-tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

(2016) Maren C. Podszun et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman

(2015) Silvia Ciffolilli et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Tocopherol long-chain metabolite α-13’-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages

(2015) Maria Wallert et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulation of inflammatory pathways by an a-tocopherol long-chain metabolite and a d-tocotrienol-related natural compound.

(2014) Lisa Schmölz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy

(2014) Qing Jiang   FREE RADICAL BIOLOGY AND MEDICINE

Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs

(2014) Maren C. Podszun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro

(2014) Nadine Grebenstein et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro

(2013) Maria Wallert et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14Gene) Causes Severe Perturbations in Vitamin E Metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF LIPID RESEARCH

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress

(2010) Marc Birringer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Analysis of Multiple Metabolites of Tocopherols and Tocotrienols in Mice and Humans

(2010) Yang Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Forms of Vitamin E and 13'-Carboxychromanol, a Long-Chain Vitamin E Metabolite, Inhibit Leukotriene Generation from Stimulated Neutrophils by Blocking Calcium Influx and Suppressing 5-Lipoxygenase Activity, Respectively

(2010) Z. Jiang et al.   JOURNAL OF IMMUNOLOGY

Gene-Regulatory Activity of α-Tocopherol

(2010) Gerald Rimbach et al.   MOLECULES

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

α-tocopherol β-oxidation localized to rat liver mitochondria

(2009) Debbie J. Mustacich et al.   FREE RADICAL BIOLOGY AND MEDICINE

γ-Tocotrienol and γ-Tocopherol Are Primarily Metabolized to Conjugated 2-(β-carboxyethyl)-6-Hydroxy-2,7,8-Trimethylchroman and Sulfated Long-Chain Carboxychromanols in Rats

(2009) Helene Freiser et al.   JOURNAL OF NUTRITION

Meroditerpenoids from the southern Australian marine brown alga Sargassum fallax

(2009) Priyanka Reddy et al.   PHYTOCHEMISTRY

Configuration of the vitamin E analogue garcinoic acid extracted from garcinia kola seeds

(2008) Francesco Mazzini et al.   CHIRALITY

Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis

(2008) Seulgi Hur et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin E dependent microRNA regulation in rat liver

(2008) Sonja Gaedicke et al.   FEBS LETTERS

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

(2008) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA