The long chain α-tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Vitamin E–drug interactions: molecular basis and clinical relevance

(2014) Maren Podszun et al.   NUTRITION RESEARCH REVIEWS

Plastochromanol-8: Fifty years of research

(2014) Jerzy Kruk et al.   PHYTOCHEMISTRY

Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro

(2013) Maria Wallert et al.   FREE RADICAL BIOLOGY AND MEDICINE

Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells

(2012) Johanna Weiss et al.   BIOCHEMICAL PHARMACOLOGY

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14Gene) Causes Severe Perturbations in Vitamin E Metabolism

(2012) Sabrina A. Bardowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs

(2012) Maren C. Podszun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Do tocotrienols have potential as neuroprotective dietary factors?

(2011) Jan Frank et al.   AGEING RESEARCH REVIEWS

Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products

(2011) Alaa H. Abuznait et al.   FOOD AND CHEMICAL TOXICOLOGY

α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

(2011) Han-A Park et al.   STROKE

Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress

(2010) Marc Birringer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Analysis of Multiple Metabolites of Tocopherols and Tocotrienols in Mice and Humans

(2010) Yang Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Vitamin E Supplementation and Hepatic Drug Metabolism in Humans

(2009) Michael W Clarke et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors

(2008) A. Gupta et al.   DRUG METABOLISM AND DISPOSITION

Vitamin E dependent microRNA regulation in rat liver

(2008) Sonja Gaedicke et al.   FEBS LETTERS

Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice

(2008) Debbie J. Mustacich et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA