Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease—Activated Receptor-2, in Human Corneal Epithelial Cells

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients

(2018) Maria C. Edman et al.   Scientific Reports

Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren’s Syndrome

(2017) Zhen Meng et al.   PLoS One

Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ

(2017) Joseph S. Ainscough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-36 cytokines in autoimmunity and inflammatory disease

(2017) Liping Ding et al.   Oncotarget

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

(2017) Maia Tato et al.   Scientific Reports

Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis

(2017) Masato Dekita et al.   Frontiers in Pharmacology

Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease

(2017) Rongjun Liu et al.   PLoS One

Elevation of autophagy markers in Sjögren syndrome dry eye

(2017) Yong-Soo Byun et al.   Scientific Reports

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

(2016) T Lieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD

(2016) Takahiro Nakajima et al.   DISEASE MARKERS

siRNA Targeting the 2Apro Genomic Region Prevents Enterovirus 71 Replication In Vitro

(2016) Haibing Liu et al.   PLoS One

Sjögren syndrome

(2016) Pilar Brito-Zerón et al.   Nature Reviews Disease Primers

Expression of Protease-Activated Receptor-2 in SZ95 Sebocytes and its Role in Sebaceous Lipogenesis, Inflammation, and Innate Immunity

(2015) Sang E. Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications

(2015) S. Kumar VR et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin S-Dependent Protease-Activated Receptor-2 Activation: A New Mechanism of Endothelial Dysfunction

(2015) D. J. Nikolic-Paterson   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Changes in The Ocular Surface through Technology and Time

(2015) Gary N. Foulks   Ocular Surface

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

(2015) Gary N. Foulks et al.   Ocular Surface

Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma

(2014) Terence Kin-Wah Lee et al.   HEPATOLOGY

Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

(2014) Vadim Iablokov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

(2013) Khader Valli Rupanagudi et al.   ANNALS OF THE RHEUMATIC DISEASES

Toward Drugs for Protease-Activated Receptor 2 (PAR2)

(2013) Mei-Kwan Yau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation

(2012) Jennifer M. Cox et al.   ANALYTICAL BIOCHEMISTRY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

(2011) Fiore Cattaruzza et al.   GASTROENTEROLOGY

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

(2011) Nari Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes

(2010) Sang Eun Lee et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice

(2010) Yoonjung Park et al.   BASIC RESEARCH IN CARDIOLOGY

Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis

(2010) Dana Haves-Zburof et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IL-1 family nomenclature

(2010) Charles Dinarello et al.   NATURE IMMUNOLOGY

Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes

(2009) C. Ishikawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo

(2009) Giancarlo Ramelli et al.   IMMUNOLOGY

Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells

(2009) Gabriel M. Gordon et al.   JOURNAL OF CELLULAR PHYSIOLOGY