Article
Biochemistry & Molecular Biology
Jingyu Wang, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Mei Li, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Chenghong Zhang, Ying Zhao, Ying Gao
Summary: Atherosclerosis, a chronic inflammatory disease and leading cause of death worldwide, has been linked to dysregulation of microRNAs (miRNAs). In this study, miR-520c-3p was found to reduce atherosclerotic plaque size and collagen content, and inhibit proliferation and migration of VSMCs by targeting RelA/p65, indicating a potential therapeutic strategy for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiyang Han, Haidi Hu, MingZhu Yin, Yu Lin, Yan Yan, Peng Han, Bing Liu, Bao Jing
Summary: HOXA1 plays a significant role in the transformation of vascular smooth muscle cells (VSMCs) and may be involved in the pathogenesis of atherosclerosis (AS). Inhibition of HOXA1 can alleviate weight gain, inflammatory response, lipid metabolism disorder, and atherosclerotic plaque formation in AS mice. Furthermore, HOXA1 knockdown suppresses the VSMC-to-macrophage phenotypic switch and inflammation in POV-PC-treated VSMCs by regulating NF-κB p65 and KLF4.
MOLECULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Danyang Li, Mihua Liu, Zhe Li, Guo Zheng, Amei Chen, Lei Zhao, Ping Yang, Li Wei, Yaxi Chen, Xiong Z. Ruan
Summary: The presence of sterol-resistant SCAP in vascular smooth muscle cells of mice induces vascular inflammation, endothelial dysfunction, and accelerates atherosclerosis progression by activating the NLRP3 inflammasome pathway.
Article
Biochemistry & Molecular Biology
Ming Cai, Ziqing Wang, Thi Thu Trang Luu, Dakai Zhang, Brian Finke, Jingquan He, Li Wei Rachel Tay, Gilbert Di Paolo, Guangwei Du
Summary: Phospholipase D1 plays a critical role in neointima formation, mediating VSMC proliferation signal by promoting the production of reactive oxygen species (ROS).
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Cell Biology
Yaqiong He, Rongning Wang, Peng Zhang, Jianlong Yan, Nan Gong, Yuhang Li, Shaohong Dong
Summary: The novel adipokine chemerin is positively correlated with the severity of atherosclerosis (AS) and its underlying mechanisms in AS remain unclear. Research showed that targeting the chemerin/chemokine-like receptor 1 (CMKLR1) / Lipocalin-2 (LCN2) signaling pathway may be a reasonable treatment modality for AS, as it inhibits vascular smooth muscle cells (VSMCs) proliferation and migration through p38/MAPK and Wnt/beta-catenin signaling pathways.
Article
Biochemistry & Molecular Biology
Jian-Zhi Zhao, Qi-Yao Li, Jia-Jie Lin, Li-Yun Yang, Mei-Yang Du, Yu Wang, Ke-Xin Liu, Ze-An Jiang, Huan-Huan Li, Si-Fan Wang, Bo Sun, Shi-Qing Mu, Bin Li, Kun Liu, Miao Gong, Shao-Guang Sun
Summary: This study explored the potential of tsRNAs in human aortic smooth muscle cell (HASMC) proliferation and found that during HASMC proliferation, the expression levels of many tsRNAs are altered. AS-tDR-000067 and AS-tDR-000076 act as new factors promoting VSMC proliferation.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Nutrition & Dietetics
Tsung-Yuan Yang, Yi-Liang Wu, Meng-Hsun Yu, Tung-Wei Hung, Kuei-Chuan Chan, Chau-Jong Wang
Summary: The study found that mulberry leaf extract and neochlorogenic acid can inhibit the proliferation and migration of rat aortic vascular smooth muscle cells under diabetic conditions. These effects may be achieved through the inhibition of FAK/small GTPase proteins, PI3K/Akt, and Ras-related signaling.
Review
Biochemistry & Molecular Biology
Gang Wang, Yulin Luo, Xiaojun Gao, Yu Liang, Feifei Yang, Jianbo Wu, Dan Fang, Mao Luo
Summary: Alterations in the vascular smooth muscle cells (VSMC) phenotype, regulated by microRNAs (miRNAs), play a critical role in cardiovascular diseases. Aberrant miRNA expression targets specific genes involved in VSMC phenotypic transformation, affecting atherosclerosis, hypertension, and coronary artery disease. This review highlights the progress in understanding miRNAs' mechanisms and functions in VSMC phenotypic regulation, with potential implications for clinical diagnosis, prognosis, and therapeutic targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Shulan Pi, Ling Mao, Jiefang Chen, Hanqing Shi, Yuxiao Liu, Xiaoqing Guo, Yuanyuan Li, Lian Zhou, Hui He, Cheng Yu, Jianyong Liu, Yiping Dang, Yuanpeng Xia, Quanwei He, Huijuan Jin, Yanan Li, Yu Hu, Yiliang Miao, Zhenyu Yue, Bo Hu
Summary: The P2RY12 receptor plays a crucial role in regulating macrophagy and VSMC-derived foam cell formation in advanced atherosclerosis, by inhibiting cholesterol efflux and blocking autophagy pathways. Inhibition of the P2RY12 receptor may be a potential therapeutic target for treating atherosclerosis.
Article
Medicine, General & Internal
Shiva Ganjali, Seyed Hamid Aghaee-Bakhtiari, Zeljko Reiner, Amirhossein Sahebkar
Summary: This study aimed to investigate the diagnostic capability of miRNA-223 in determining in-stent restenosis (ISR). The results showed that the serum level of miRNA-223 was significantly higher in ISR patients compared to non-ISR patients, and the high level of miRNA-223 was strongly associated with the risk of ISR. These findings suggest that miRNA-223 may have potential value in predicting the occurrence of ISR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
McKenzie Clark, Ann M. Centner, Vladimir Ukhanov, Ravinder Nagpal, Gloria Salazar
Summary: Polyphenols found in fruits and vegetables are associated with a reduced incidence of cardiovascular disease (CVD). The study shows that blackberry supplementation reduces atherosclerosis in male mice and investigates the potential role of gallic acid (GA), a polyphenol abundant in blackberry, in plaque reduction. In vitro experiments demonstrate that GA reduces cell signaling associated with proliferation, migration, and senescence. Animal experiments reveal that GA reduces atherosclerosis only in male mice and is associated with lower inflammation and improved gut health. The study provides insights into the sex-dependent effects of GA on CVD and suggests its potential as a supplementation for males with atherosclerosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Yuliya V. V. Markina, Tatiana V. V. Kirichenko, Taisiya V. V. Tolstik, Anastasia I. I. Bogatyreva, Ulyana S. S. Zotova, Vadim R. R. Cherednichenko, Anton Yu. Postnov, Alexander M. M. Markin
Summary: Cardiovascular diseases (CVD) and atherosclerosis remain the leading cause of death globally. Early pathogenetic therapy for CVD is urgently needed, and cell therapy shows promise as the most effective treatment strategy. However, there are limitations to cell therapy. This review summarizes the main targets of cell therapy for CVD, particularly atherosclerosis, based on analysis of PubMed and Scopus databases up to May 2023.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Evgeny E. Bezsonov, Tatyana V. Popkova, Antonina V. Starodubova, Alexander N. Orekhov
Summary: Atherosclerosis, a well-known disease in medicine, is believed to be related to the immune response in the body. Immune therapies are considered as a potential approach to reduce cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Ling-Yao Kong, Cui Liang, Peng-Cheng Li, Yi-Wei Zhang, Sheng-Dong Feng, Dian-Hong Zhang, Rui Yao, Lu-Lu Yang, Zheng-Yang Hao, Hao Zhang, Xiao-Xu Tian, Chen-Ran Guo, Bin-Bin Du, Jian-Zeng Dong, Yan-Zhou Zhang
Summary: This study reveals the role of MTMR14 in cardiovascular biology, demonstrating its ability to prevent neointima formation and VSMC proliferation by inhibiting PLK1. This finding provides a new therapeutic target for the treatment of restenosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
Junqing An, Liu Ouyang, Changjiang Yu, Sean Michael Carr, Tharmarajan Ramprasath, Zhixue Liu, Ping Song, Ming-Hui Zou, Ye Ding
Summary: This study aimed to evaluate the impact of lysosomal dysfunction-mediated NLRP3 inflammasome activation in vascular smooth muscle cells (VSMC) on atherosclerotic plaque formation and stability. The results showed that nicotine accelerated plaque formation and enhanced instability through lysosomal dysfunction-mediated NLRP3 inflammasome activation. This suggests that nicotine increases the risk of atherosclerosis and plaque instability.
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Pharmacology & Pharmacy
Olena Litvinova, Elisabeth Klager, Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Oliver Kimberger, Maria Kletecka-Pulker, Harald Willschke, Atanas G. Atanasov
Summary: Digital pills are new technologies that aim to improve healthcare. The bibliometric analysis revealed an increasing number of publications on digital pills, indicating the growing importance of this field. The main research areas include efficacy and safety analysis for mental disorders, treatment and costs of tuberculosis therapy, and features of treatment for diabetes, cardiovascular diseases, and AIDS. The effectiveness and safety of digital pills have been demonstrated, but further research is still needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mojca Hribersek, Fabian Eibensteiner, Lorenz Kapral, Anna Teufel, Faisal A. Nawaz, Merisa Cenanovic, Chandragiri Siva Sai, Hari Prasad Devkota, Ronita De, Rajeev K. Singla, Emil D. Parvanov, Christos Tsagkaris, Atanas G. Atanasov, Eva Schaden
Summary: This study explores the communication between hospital-based healthcare providers and patients' loved ones, focusing on the rigorous mitigation measures implemented during the COVID-19 pandemic. The findings highlight the importance of communication between patients, their loved ones, and hospitals, and the barriers to communication beyond visitation restrictions. The study emphasizes the implementation of family-centered care in adult nursing clinical practice.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Analytical
Xiaomu Zhu, Ting Zhou, Shu Wang, Bengui Ye, Rajeev K. Singla, Devesh Tewari, Atanas G. Atanasov, Dongdong Wang, Simei Liu
Summary: In this study, an UPLC-ESI-MS/MS method was developed for the simultaneous quantification of nine steroidal alkaloids in Fritillariae cirrhosae bulbus (FCB) and its substitutes. Multivariate chemometric analyses were applied to distinguish FCB from its substitutes, and four compounds were discovered as potential markers for identification.
Editorial Material
Pharmacology & Pharmacy
Suresh Kumar, Sevgi Gezici, Nazim Sekeroglu, Atanas G. Atanasov, Rajeev K. Singla
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ecaterina Isacescu, Paul Chiroi, Oana Zanoaga, Andreea Nutu, Liviuta Budisan, Radu Pirlog, Atanas G. Atanasov, Ioana Berindan-Neagoe
Summary: Melanoma, the most aggressive type of skin cancer, still lacks highly effective treatments. This article aims to provide a comprehensive review on the molecular mechanisms of action regulated by polyphenols in melanoma cells. The review focuses on the in vitro and in vivo effects of polyphenol treatments on essential cellular pathways in tumors, as well as their role in regulating microRNAs and contributing to melanoma development. The goal is to provide a foundation for the development of polyphenol-based therapeutic agents in melanoma treatment.
Review
Biochemistry & Molecular Biology
Iga Bartel, Magdalena Koszarska, Nina Strzalkowska, Nikolay T. T. Tzvetkov, Dongdong Wang, Jaroslaw O. Horbanczuk, Agnieszka Wierzbicka, Atanas G. G. Atanasov, Artur Jozwik
Summary: Type 2 diabetes is a global health problem caused by a combination of environmental and genetic factors. In order to prevent and mitigate the negative consequences of type 2 diabetes, a nutritional diet rich in bioactive compounds such as polyphenols, including cyanidin-3-O-glucosidase (C3G), can be beneficial. C3G has been shown to have positive effects on diabetic parameters, including reducing inflammation, blood glucose levels, and postprandial hyperglycemia, as well as regulating gene expression related to the development of type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dongdong Wang, Logan K. Townsend, Genevieve J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A. Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A. Pileggi, Sonia Rehal, Eric M. Desjardins, Evangelia E. Tsakiridis, James S. V. Lally, Emma Sara Juracic, A. Russell Tupling, Hertzel C. Gerstein, Guillaume Pare, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J. Hawke, John R. Speakman, Denis P. Blondin, Graham P. Holloway, Sebastian Beck Jorgensen, Gregory R. Steinberg
Summary: Caloric restriction is effective in treating non-alcoholic fatty liver disease and improving insulin sensitivity, but weight loss is usually not maintained due to physiological adaptations that suppress energy expenditure. Treatment with recombinant GDF15 can reduce obesity and improve glycaemic control by suppressing food intake. Additionally, GDF15 counteracts compensatory reductions in energy expenditure, leading to greater weight loss and improvements in non-alcoholic fatty liver disease compared to caloric restriction alone. This effect of GDF15 on maintaining energy expenditure during calorie restriction requires a GFRAL-beta-adrenergic-dependent signaling axis.
Editorial Material
Endocrinology & Metabolism
Logan K. Townsend, Dongdong Wang, David C. Wright, Denis P. Blondin
Article
Veterinary Sciences
Vasil Radoslavov Pirgozliev, Stephen Charles Mansbridge, Isobel Margaret Whiting, Kristina Kljak, Artur Jozwik, Judith Maria Rollinger, Atanas Georgiev Atanasov, Stephen Paul Rose
Summary: This study investigated the impact of dietary black peppercorn and xylanase on male Ross 308 broiler chicken. The results showed that feeding black peppercorn reduced bird growth and digestibility but increased blood high-density lipoprotein. Feeding xylanase increased bird growth, dietary energy, and nutrient digestibility.
VETERINARY SCIENCES
(2023)
Article
Health Care Sciences & Services
Olena Litvinova, Fabian Peter Hammerle, Jivko Stoyanov, Natalia Ksepka, Maima Matin, Michal Lawinski, Atanas G. Atanasov, Harald Willschke
Summary: This study conducted a comprehensive patent and bibliometric analysis to explore the development and application of pulse oximeters in the field of digital medicine. The findings highlight the increasing importance of pulse oximeters in digitally-enabled medical practice and identify six primary research clusters related to these devices. The study suggests the potential of leveraging digital technologies in pulse oximetry for advancing the understanding, diagnosis, prevention, and treatment of cardio-respiratory pathologies.
Article
Plant Sciences
Donghan Cui, Yajuan Chen, Bengui Ye, Wenhao Guo, Dongdong Wang, Jun He
Summary: Neurodegenerative diseases are common in older adults, and natural products have shown promising results in improving these diseases. Recent studies have identified neuroinflammatory mechanisms and signaling pathways associated with the occurrence and development of these diseases. This study aims to review the mechanism of action of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease, providing a theoretical basis for clinical practice.
