Article
Food Science & Technology
Siqi Zhao, Yanzi Nan, Runyu Yao, Langhong Wang, Xinan Zeng, Rana Muhammad Aadil, Muhammad Asim Shabbir
Summary: The aim of this research was to investigate the antimicrobial characteristics and mechanism of hesperetin against Alicyclobacillus acidoterrestris vegetative cells. The results showed that hesperetin had effective antimicrobial activity on Alicyclobacillus acidoterrestris vegetative cells, leading to significant damage to cell integrity and prevention of cell growth. Transcriptomic analysis revealed that hesperetin affected nitrogen metabolism, amino acid metabolism, nutrient transport, energy metabolism, and flagella motility, providing new insights into its antimicrobial effects and mechanism.
Article
Food Science & Technology
Hongmei Ju, Hong Chen, Anni Xiang, Yuwei Wang, Tianli Yue, Yahong Yuan
Summary: The study showed that cell-free supernatants from Lactobacillus paracasei strain MRS-4 have strong inhibitory effects on Alicyclobacillus acidoterrestris, mainly through the production of organic acids that disrupt cellular integrity, causing leakage of DNA and proteins.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Zhouli Wang, Yu Tian, Qi Wang, Tianmin Guo, Yahong Yuan, Tianli Yue, Hang Jia, Qian Ge, Zidan Zhao, Rui Cai
Summary: This study investigated the antibacterial activity and underlying mechanism of five preservatives (epsilon-polylysine, propylparaben, monocaprin, octyl gallate, and heptylparaben) against Alicyclobacillus acidoterrestris in apple juice. Results showed that all five preservatives exerted antibacterial activity through a multiple bactericidal mechanism. Monocaprin and octyl gallate had the highest antibacterial activity, with the minimum inhibitory concentration (MIC) values of 22.5 and 6.25 mg/L, respectively. Additionally, the preservatives altered the permeability of the cell membrane, leading to a leakage of intracellular electrolytes. The treatment with epsilon-polylysine, propylparaben, and monocaprin increased the leakage of intracellular protein, while propylparaben and octyl gallate reduced the levels of cellular adenosine triphosphate. Monocaprin and octyl gallate could effectively inactivate the contamination of A. acidoterrestris in apple juice without significant adverse effects on the juice quality.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Wang, Lin Yue, Sobia Niazi, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: The study synthesized a novel hybrid flocculant with antibacterial activity, HTCC-CA, by conjugating cinnamic acid with HTCC. The results showed that HTCC-CA derivatives exhibited excellent flocculation efficiency and high antibacterial activity, making them promising agents for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lin Yue, Min Wang, Imran Mahmood Khan, Jianguo Xu, Chifang Peng, Zhouping Wang
Summary: In this study, cinnamic acid conjugated hydroxypropyl chitosan derivatives with different degrees of substitution were successfully synthesized and showed good antibacterial activity against Staphylococcus aureus and Escherichia coli. The derivatives exhibited better water solubility than chitosan and had a significant inhibitory effect on biofilm formation. These results suggest the potential applicability of these derivatives in the treatment of biofilm-associated infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Xinhong Liang, Cunjian Tu, Yongchao Li, Junliang Sun, Ruixiang Zhao, Junjian Ran, Lingxia Jiao, Junchao Huang, Junrui Li
Summary: This study evaluated the antibacterial activity of quercetin against Alicyclobacillus acidoterrestris and found that quercetin effectively damaged the cell membrane and enhanced the hydrophobicity of the bacterial surface, resulting in significant bactericidal effects. Quercetin also reduced intracellular protein content and impeded ATPase synthesis, leading to bacterial apoptosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Yuxiang Zhang, Jianping Wei, Hong Guo, Chen Niu, Yahong Yuan, Tianli Yue
Summary: This study revealed the antibacterial mechanism of cinnamic acid (CA) against food-derived Pseudomonas fragi 38-8. CA exerted its antibacterial effect mainly by disrupting cell membrane homeostasis, leading to depolarization of the cell membrane, intracellular pH reduction, and decrease in intracellular ATPase activity, ultimately inhibiting bacterial growth.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Yuhan Sun, Yiheng Shi, Hang Jia, Hao Ding, Tianli Yue, Yahong Yuan
Summary: In this study, selenium nanoparticles (SeNPs) were produced during the fermentation process of a selenium-enriched strain Monascus purpureus 2322, and their antibacterial activity against Alicyclobacillus acidoterrestris was investigated. The synthesized SeNPs were spherical with a diameter of approximately 48 nm, and they were found to severely damage the integrity of bacterial cells, leading to leakage of cellular contents. As a result, the growth of A. acidoterrestris was inhibited in the presence of SeNPs, suggesting SeNPs as a potential antibacterial agent against this bacterium.
Article
Chemistry, Applied
Hang Jia, Yaping Zhang, Qi Guo, Xuejun Zeng, Yahong Yuan, Zhouli Wang, Zhenpeng Gao, Tianli Yue
Summary: In this study, Fe3O4-PAA-EPL nanospheres with antibacterial activity were successfully synthesized and demonstrated effective inhibition against Alicyclobacillus acidoterrestris. Characterization techniques such as XRD, FTIR, XPS, VSM, SEM, and TEM confirmed the damage to bacterial cell membranes. The magnetic nanospheres can be easily separated using an external magnet, providing a promising method for controlling A. acidoterrestris.
Review
Nutrition & Dietetics
Liang Wang, Xiaoqi Pan, Lishi Jiang, Yu Chu, Song Gao, Xingyue Jiang, Yuhui Zhang, Yan Chen, Shajie Luo, Cheng Peng
Summary: This article introduces the biological activities and applications of chlorogenic acid (CGA) in the food industry. CGA exhibits various biological activities, including antioxidant, liver and kidney protection, antibacterial, anti-tumor, metabolic regulation, and anti-inflammatory effects. In the food industry, CGA can be used as food additives, storage agents, packaging materials, etc.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Nahid Shahabadi, Alireza Akbari, Fatemeh Karampour, Monireh Falsafi, Saba Zendehcheshm
Summary: Nanoparticles with both anticancer and antibacterial properties were synthesized by loading chlorogenic acid on magnetic nanoparticles. The nanoparticles showed anticancer activity through DNA binding and exhibited no cytotoxicity in interaction with human serum albumin. Additionally, the nanoparticles demonstrated good antibacterial function.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Masoud Shafaghatlonbar, Ghodsieh Bagherzade
Summary: Chlorogenic acid (CGA) is a compound found in various foods and has the ability to bind with metal ions, enhancing its biological activity. CGA has gained attention for its anticancer, antioxidant, and antibacterial properties. In this study, a nanoscale copper(II) complex was synthesized using CGA as a ligand and characterized using various techniques. The complex showed remarkable catalytic activity towards alcohol oxidation and strong antibacterial activity against Staphylococcus aureus and Escherichia coli.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chunling Wei, Peiwu Cui, Xiangqian Liu
Summary: Antibacterial resistance is a serious global health problem, and scientists are focusing on developing new antibacterial drugs from natural products. This study investigated the antibacterial activity and mechanism of madecassic acid (MA), a compound isolated from Chinese medicine. It was found that MA had inhibitory effects on eight pathogenic bacteria, with a minimum inhibitory concentration of 31.25μg/mL for Staphylococcus aureus.
Article
Agriculture, Multidisciplinary
Hang Jia, Xuejun Zeng, Rui Cai, Zhouli Wang, Yahong Yuan, Tianli Yue
Summary: In this study, flower-like magnetic molybdenum disulfide (Fe3O4@ MoS2) nanoparticles were synthesized and modified to possess antibacterial activity against Alicyclobacillus acidoterrestris. The nanocomposites showed effective antibacterial activity by damaging the bacterial membrane and inhibiting dehydrogenase enzymes. Additionally, the presence of the nanocomposites disrupted the antioxidant defense system and caused oxidative damage to bacteria. The research also confirmed the biocompatibility of the nanocomposites. This study provides a new pathway for inhibiting A. acidoterrestris in the juice industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Ruixia Wang, Xuyang Qin, Yanjin Du, Zhongguo Shan, Chao Shi, Kerang Huang, Jiacheng Wang, Kangkang Zhi
Summary: In this study, a series of CA-esterified CDS nanoparticles were successfully fabricated to encapsulate curcumin, showing excellent biosafety, high encapsulation efficiency, sustained release, increased water solubility, enhanced photothermal stability, superior biofilm scavenging ability, and enhanced antibacterial effects compared to free curcumin.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Food Science & Technology
Hong Chen, Xiaohai Yan, Gengan Du, Qi Guo, Yiheng Shi, Jiale Chang, Xiaoyu Wang, Yahong Yuan, Tianli Yue
Summary: This article provides an overview of the application value of lactic acid bacteria (LAB) in food preservation, including the comparison of screening methods for antifungal LAB, separation and purification techniques for antifungal compounds, and the antifungal mechanism of LAB. The research on the use of antifungal LAB in different food products is also summarized.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Xiao Zhang, Tingting Shan, Hang Jia, Chunfeng Guo, Zhouli Wang, Tianli Yue, Yahong Yuan
Summary: The study found that there were differences in the levels of free amino acids and flavor compounds between NIS and AIS fermentations, as well as variations in microbial community compositions. Specific microbial taxa were identified to play distinct roles in metabolite transformations, contributing to the understanding of flavor formation mechanisms in soybean paste production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuning Zhao, Hong Chen, Wenting Li, Qian He, Jingyimei Liang, Xiaohai Yan, Yahong Yuan, Tianli Yue
Summary: This study isolated a selenium-containing tea polysaccharide (ASeTP) and investigated its structure and effects on ulcerative colitis (UC). The results showed that ASeTP alleviated UC symptoms, protected the colonic mucosal barrier, suppressed inflammation, and modulated the gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Gengan Du, Shuaidan Chang, Qi Guo, Xiaohai Yan, Hong Chen, Kehan Shi, Yahong Yuan, Tianli Yue
Summary: This study found that Tibetan kefir (TK) can alleviate intestinal damage caused by ochratoxin A (OTA). TK increases the expression of tight junction proteins and mucins, reduces oxidative stress and inflammation, and modulates the gut microbiota, maintaining the levels of short-chain fatty acids (SCFAs). Therefore, TK may be a promising dietary strategy to prevent intestinal toxicity-based injuries.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Jia Kong, Jinyao Hu, Jia Li, Jiaxing Zhang, Yuhe Shen, Tianli Yue, Xihui Shen, Yuefei Wang, Zhonghong Li, Yinqiang Xia
Summary: Reconstructing miniaturized peptides to mimic specific protein functions is appealing but challenging. In this study, we propose a practical approach to construct a mimetic peptide of redox-sensitive green fluorescent protein-2 (roGFP2) by rethreading aromatic residues adjacent to the chromophore fragment. By fine-tuning the residues, we designed a mini tetrapeptide (Cys-Phe-Phe-His) that acts as a hydrogen peroxide sensor using ratiometric fluorescence. The roGFP2 mimetic tetrapeptide, with its assembly-induced emissions, is biocompatible, photostable, and exhibits competitive fluorescent properties compared to roGFP2. We demonstrated the ability of the ratiometric tetrapeptide to sense hydrogen peroxide in acidic chambers, providing a promising approach for artificially designing miniaturized peptides with desired functions.
ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Qiannan Zhao, Zewei Wang, Xin Wang, Xiaohai Yan, Qi Guo, Yuan Yue, Tianli Yue, Yahong Yuan
Summary: The release of phenolic compounds and their bioactivity during digestion and fermentation of mulberry leaves were investigated. The bioavailability of total phenolics and flavonoids in fermented mulberry leaves (F-MLs) were 10.14 +/- 1.81% and 6.66 +/- 0.55%, respectively. There was no significant difference in the inhibitory activity of alpha-glucosidase during gastrointestinal digestion. F-MLs exhibited higher phenolic bioaccessibility, antioxidant activities, and short-chain fatty acid production, making them a promising candidate for health food supplements.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Food Science & Technology
Rui Sun, Yefan Niu, Menghui Li, Yuanye Liu, Kai Wang, Zhenpeng Gao, Zhouli Wang, Tianli Yue, Yahong Yuan
Summary: This review discusses the rationalization of steps and sequences of pectin processing, the suitability of emerging technological applications, and the relationship between structure and intended function. The results show that natural deep eutectic pretreatment is beneficial for subsequent water extraction and can improve the extraction efficiency of ohmic heating. The right treatment sequence for emerging technologies enables pectin with unique rheological properties and prebiotic activity. Therefore, developing pectin-based synbiotics is important for protection of probiotic viability and promotion of human health.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Gengan Du, Yudie Qing, Huanzi Wang, Na Wang, Tianli Yue, Yahong Yuan
Summary: This study investigated the changes in microbial growth, physicochemical properties, phenolics, enzyme activity, and antioxidant activity of Goji berry juice during fermentation with Tibetan kefir grains (TKG). The results showed that TKG grew well in Goji berry juice, with yeasts dominating in the later stages of fermentation. The fermentation process led to significant changes in the composition of the juice, including the decrease of lactobacillus and increase of acetobacter. The fermentation also resulted in the increase of total soluble flavonoids and the identification of various compounds with potential health benefits.
Article
Nanoscience & Nanotechnology
Jianrui Qi, Zewei Wang, Xin Wen, Weiteng Tan, Yahong Yuan, Tianli Yue
Summary: By utilizing the natural biofilm on magnetosomes and copper ions, organic-inorganic nanoflowers can be synthesized, which exhibit strong antibacterial effects and promote wound healing with biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Agriculture, Multidisciplinary
Qiuxia Fan, Xinru Dong, Zewei Wang, Yuan Yue, Yahong Yuan, Zhouli Wang, Tianli Yue
Summary: Hexanal has antimicrobial activity against Vibrioparahaemolyticus, but its antibacterial effect and mechanism have not been fully studied. This research used proteomics and metabolomics to investigate the mechanism of action of hexanal. The results showed that hexanal treatment reduced ATP concentration, increased membrane permeability, and disrupted cell morphology and ultrastructure of V. parahaemolyticus. Proteomics and metabolomics analysis identified numerous differentially expressed proteins and metabolites involved in various biological pathways. Bioinformatics analysis revealed that hexanal damaged cell membranes, inhibited nucleotide metabolism, and disrupted carbohydrate and TCA cycles, leading to growth inhibition and death of V. parahaemolyticus. This study provides valuable insights into the antibacterial mechanism of hexanal and its potential application in the seafood industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Leran Wang, Rui Cai, Jierong Zhang, Xiaoshuang Liu, Saiqun Wang, Qian Ge, Zidan Zhao, Tianli Yue, Yahong Yuan, Zhouli Wang
Summary: Yeast strain 20-G was found to effectively remove OTA through biosorption and biodegradation, with peroxidase playing a key role in reducing OTA toxicity. Degradation products of OTA were identified as less toxic, and animal experiments showed that yeast 20-G intervention could mitigate OTA-induced damage in mice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Lixia Zan, Wenyi Zhang, Shufeng Shang, Yuanyuan Cui, Jinjin Pei, Yahong Yuan, Tianli Yue
Summary: The aim of this study was to investigate the effects of selenium-enriched Lactobacillus plantarum on colitis and liver inflammation induced by sodium dextran sulfate in mice. The results showed that selenium-enriched Lactobacillus plantarum alleviated inflammation symptoms in the colon and liver, downregulated NF-kappa B-P65 pathway factors, and altered the composition and structure of the gut microbiota.
Article
Biochemistry & Molecular Biology
Gengan Du, Qi Guo, Xiaohai Yan, Hong Chen, Yahong Yuan, Tianli Yue
Summary: Tibetan kefir (TK) protects the liver from ochratoxin A (OTA) induced injury by improving intestinal barriers, modulating gut microbiota and metabolites, and reducing inflammation and oxidative stress.
Article
Chemistry, Multidisciplinary
Yaxue Wang, Tianli Yue, Yahong Yuan
Summary: The aim of this study was to investigate the adsorption mechanisms of PAT by beta-1, 3-D-glucan. Through molecular docking and molecular dynamics simulation, the researchers revealed that steric complementarity, intermolecular H-bond, and Pi-Sigma interaction are the driving forces behind the interaction between beta-1, 3-D-glucan and PAT. They also found that SPG is the most promising adsorbent for PAT.
JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY
(2022)
