Article
Immunology
Takashi MaruYama, Hirofumi Miyazaki, Yun-Ji Lim, Jian Gu, Masaki Ishikawa, Taichi Yoshida, WanJun Chen, Yuji Owada, Hiroyuki Shibata
Summary: Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model, but its effect on tumor-induced immune suppression is still unclear. In this study, it was found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-beta). However, GO-Y022 had limited impact on Foxp3(+) Tregs in the gastric tumor microenvironment. Gastric tumor cells produced a large amount of L-lactate in the presence of GO-Y022, which undermined the inhibitory effect of GO-Y022 on Treg generation in response to TGF-beta. Combination treatment with GO-Y022 and 2-deoxy-d-glucose (2DG) reduced L-lactate production and Treg generation in gastric tumor cells, leading to inhibition of gastric tumor cell survival and promotion of anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Alexander Quaas, Aylin Pamuk, Sebastian Klein, Jennifer Quantius, Jan Rehkaemper, Atakan G. Barutcu, Josef Rueschoff, Thomas Zander, Florian Gebauer, Axel Hillmer, Reinhard Buettner, Wolfgang Schroeder, Christiane J. Bruns, Heike Loeser, Birgid Schoemig-Markiefka, Hakan Alakus
Summary: The study revealed a sex-specific prognostic effect of TANs in gastric and esophageal adenocarcinoma, with a favorable impact observed in the chromosomal instable subtype of gastric cancer and female patients. This suggests that TANs may play a significant role in the tumor microenvironment of solid tumors.
Article
Oncology
Marina Alessandra Pereira, Marcus Fernando Kodama Pertille Ramos, Andre Roncon Dias, Leonardo Cardili, Rafael Dyer Rodrigues de Moraes, Renan Ribeiro E. Ribeiro, Venancio Avancini Ferreira Alves, Bruno Zilberstein, Evandro Sobroza de Mello, Ulysses Ribeiro Jr
Summary: This study investigated the use of tumor-infiltrating lymphocytes (TILs) and programmed cell death ligand 1 (PD-L1) status as prognostic biomarkers in patients with remnant gastric cancer (RGC) to develop an immune-related score. The results showed that the score based on immune parameters could accurately distinguish prognostic groups in RGC patients. Patients in the high-risk and intermediate-risk groups had worse disease-free survival and overall survival rates compared to those in the low-risk group. Lymph node metastasis and the immune score risk groups were identified as independent factors associated with worse survival.
CHINESE JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
B. Saberzadeh-Ardestani, N. R. Foster, H. E. Lee, Q. Shi, S. R. Alberts, T. C. Smyrk, F. A. Sinicrope
Summary: The study found that the association of TIL densities with patient survival varies by primary tumor sidedness and clinical risk group in stage III colon cancer, with a higher contribution of TILs to DFS in right-sided tumors, especially in high-risk patients.
ANNALS OF ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Yunshuo Zhao, Xiaotong Chen, Zhe Ding, Chuanjie He, Guanfei Gao, Sifan Lyu, Yanfeng Gao, Jiangfeng Du
Summary: This study successfully identified a CD39 inhibitor through a combination of methods, demonstrating its effectiveness in inhibiting CD39 enzyme activity and suppressing tumor cell proliferation. Understanding the binding mode and mechanism of action of the inhibitor can potentially lead to further optimization and exploration of its anticancer activity in vivo.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Review
Oncology
Karolina Frankowska, Michal Zarobkiewicz, Izabela Dabrowska, Agnieszka Bojarska-Junak
Summary: Tumor microenvironment (TME) is a complex entity that includes not only tumor cells but also various populations of immune cells. Tumor infiltrating lymphocytes (TILs) are highly reactive against the tumor component and play a key role in mediating responses to therapy. Recent studies have explored the potential utility of various imaging methods in assessing the level of TILs, particularly in breast and lung cancers.
Article
Oncology
Eo Jin Kim, Heejung Chae, Young-Soo Park, Min-Hee Ryu, Hyung-Don Kim, Junyoung Shin, Yang Soon Park, Mee Sun Moon, Yoon-Koo Kang
Summary: This retrospective study found that EBVaGC accounted for 5% in metastatic, recurrent, or locally advanced unresectable gastric cancer. Although EBVaGC was not associated with better response to first-line cytotoxic chemotherapy or progression-free survival (PFS), it showed a trend toward better overall survival.
Article
Oncology
Qi Zou, Xiaolin Wang, Donglin Ren, Bang Hu, Guannan Tang, Yu Zhang, Meijin Huang, Rish K. Pai, Daniel D. Buchanan, Aung Ko Win, Polly A. Newcomb, William M. Grady, Huichuan Yu, Yanxin Luo
Summary: This study developed a DNA methylation-based signature for CD8+ TILs in colorectal cancer, which showed a strong association with prognosis and immune markers. The QASM assay developed for CD8+ MeTIL markers provided a quantitative and accurate measurement of CD8+ TILs distribution in tumor tissues, indicating potential as a biomarker for therapeutic approaches, including immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Imamura, Yusuke Tomita, Ryo Sato, Tokunori Ikeda, Shinji Iyama, Takayuki Jodai, Misako Takahashi, Akira Takaki, Kimitaka Akaike, Shohei Hamada, Shinya Sakata, Koichi Saruwatari, Sho Saeki, Koei Ikeda, Makoto Suzuki, Takuro Sakagami
Summary: This study found that the infiltration of drebrin-expressing T cells within the tumor cell nest in resectable squamous cell lung cancer patients is associated with short relapse-free survival and overall survival. The in vitro induced drebrin(+) T cells co-express multiple exhaustion-associated molecules. Single-cell RNA-sequencing analysis confirmed that exhausted tumor-infiltrating CD8(+) T cells specifically expressed drebrin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Dong-Hoe Koo, Min-Hee Ryu, Mi-Yeon Lee, Mee-Sun Moon, Yoon-Koo Kang
Summary: By analyzing clinical data of MRGC patients, six prognostic factors were identified. A simple and effective prognostic model was developed based on these factors, which can help predict patients' survival rates.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-jie Tang, Qing-cong Kong, Zi-xuan Cheng, Yun-shi Liang, Zhe Jin, Lei-xin Chen, Wen-ke Hu, Ying-ying Liang, Xin-hua Wei, Yuan Guo, Xin-qing Jiang
Summary: This study investigated the effect of imaging features at different DCE-MRI phases on predicting TIL levels in breast cancer. Results showed that image features from delayed phase MRI had the best predictive performance, and the fusion multi-sequence radiomics model and combined radiomics-based clinical model performed the best in predicting TILs.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Elsa N. Garza-Trevino, Herminia G. Martinez-Rodriguez, Paulina Delgado-Gonzalez, Orlando Solis-Coronado, Rocio Ortiz-Lopez, Adolfo Soto-Dominguez, Victor M. Trevino, Gerardo R. Padilla-Rivas, Jose F. Islas-Cisneros, Adriana G. Quiroz-Reyes, Salvador L. Said-Fernandez
Summary: This study found that in CRC patients, 59% of tissues showed resistance, with higher expression of CD44 and CD24 markers. There is an association in gene expression between resistant tissues and CSC, with the KRT-18 gene overexpressed in most resistant isolates.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Shunji Endo, Kazuhiro Nishikawa, Masakazu Ikenaga, Kazumasa Fujitani, Junji Kawada, Tomoki Yamatsuji, Hisako Kubota, Masaharu Higashida, Yoshinori Fujiwara, Tomio Ueno
Summary: Patients with gastric cancer and positive peritoneal lavage cytology have a poor prognosis, with factors such as age, performance status, nutritional index, extent of lymphadenectomy, tumor type, and postoperative chemotherapy influencing survival. Lymph node metastasis and postoperative chemotherapy are independent risk factors for death in these patients. The most beneficial postoperative chemotherapy regimen remains uncertain.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Bradley Sinclair White, Sivasish Sindiri, Victoria Hill, Billel Gasmi, Shirley Nah, Jared J. Gartner, Todd D. Prickett, Yong Li, Devikala Gurusamy, Paul Robbins, Steven A. Rosenberg, Vid Leko
Summary: Metastatic cholangiocarcinoma (CC), a type of gastrointestinal cancer, has a poor prognosis and cannot be cured by current therapies. Previous research has shown that adoptive transfer of autologous tumor infiltrating lymphocytes (TILs) that recognize tumor-specific mutations can lead to cancer regression. This study aimed to determine if TILs could recognize FGR2 fusions in patients with CC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Microbiology
William D. D. Orsi
Summary: This report describes a method for rapidly measuring total adenylate (ATP + ADP + AMP) in marine sediment samples to estimate microbial biomass. The method involves adding boiled MilliQ water to sediments, which increases the detection limit for ATP + ADP + AMP by up to 100-fold. The method allows for the measurement of ATP + ADP + AMP in low-biomass sub-seafloor sediment cores and can be used as an additional biomass proxy.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Oncology
Ji Yea Lee, Yeonsoo Jang, Woojin Hyung
Summary: This study investigated the mediating effects of illness perception on psychological distress in patients with newly diagnosed gastric cancer. It also identified the factors influencing illness perception in these patients. The results showed that social support, physical symptoms, and satisfaction with patient education significantly influenced illness perception, and illness perception fully mediated the relationship between these variables and psychological distress.
Article
Nursing
Ji Yea Lee, Eui Geum Oh, Woo Jin Hyung, Hyoung-Il Kim
Summary: This study translated and validated the Korean version of the PG-SGA scale, demonstrating its validity and utility for assessing malnutrition in patients with gastric cancer. A new cut-off score could be used to assess malnutrition in patients with gastric cancer, with one-third of patients experiencing malnutrition.
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Medicine, General & Internal
Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon. B. B. Mills, Sung Hoon Noh, Jae-Ho Cheong
Summary: In this study, the role of PGC1 alpha in regulating cancer cell viability under metabolic and genotoxic stress was investigated. The findings suggest that PGC1 alpha is a key regulator of anti-apoptosis in metabolic and genotoxic stress-resistant cells, and it may serve as a potential therapeutic target for refractory cancers.
Article
Oncology
Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Hyoung-Il Kim, Woo Jin Hyung, Yoo Min Kim
Summary: This study aimed to identify the clinical features of chylous ascites and evaluate the treatment outcomes. Results showed that patients with chylous ascites had a longer length of hospital stay, and low body mass index, surgical resection extent were associated with the occurrence of chylous ascites. Adequate initial treatment for chylous ascites after radical gastrectomy for gastric cancer can be achieved with a fat-controlled diet and medication.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Multidisciplinary Sciences
Bo Kyung Yoon, Hyeonhui Kim, Tae Gyu Ohd, Se Kyu Oh, Sugyeong Jo, Minki Kim, Kyu-Hye Chun, Nahee Hwang, Suji Lee, Suyon Jin, Annette R. Atkins, Ruth T. Yu, Michael Downes, Jae-woo Kim, Hyunkyung Kim, Ronald M. Evans, Jae-Ho Cheong, Sungsoon Fang
Summary: Molecular classification of gastric cancer identified a subgroup of patients with poor prognosis and chemoresistance, called SEM type, which exhibits a distinct metabolic profile characterized by high levels of glutaminase. These SEM type gastric cancer cells are resistant to glutaminolysis inhibition due to the upregulation of the PHGDH-mediated mitochondrial folate cycle pathway under glutamine starvation. The metabolic plasticity in SEM type GC cells is associated with open chromatin structure and driven by ATF4/CEBPB. The coinhibition of GLS and PHGDH effectively eliminates stemness-high cancer cells, providing a potential treatment strategy for chemoresistant GC patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim
Summary: This study conducted a comprehensive investigation on the failure to rescue (FTR) after radical gastrectomy for gastric cancer patients and explored the associations between FTR and clinicopathologic factors, operative features, and complication types. The study found that older age, high ASA score, and serosa exposure were associated with FTR. Furthermore, patients who underwent gastrectomy in recent years had lower mortality rates when complications occurred. This study is important as it reveals the risk factors for FTR and provides reference for clinical treatment.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Sung Hyun Park, Ki-Yoon Kim, Yoo Min Kim, Woo Jin Hyung
Summary: The feasibility of a patient-specific 3-D surgical navigation system for preoperative planning and intraoperative guidance during robotic gastric cancer surgery was validated. This system enables visualization of all the required anatomy for gastrectomy in 3-D models without any error.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
Summary: LOXL2 plays a significant role in drug resistance and EMT regulation in pancreatic cancer, and its inhibition reduces cancer stemness by regulating MAPK signaling activity. The activation of glucose metabolism and regulation of NF-kappa B signaling contribute to LOXL2 induction and cancer progression in gemcitabine-resistant pancreatic cancer.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Surgery
Naruhiko Ikoma, Travis Grotz, Hirofumi Kawakubo, Hyoung-Il Kim, Satoru Matsuda, Yuki Hirata, Atsushi Nakao, Loretta A. Williams, Xin Shelley Wang, Tito Mendoza, Xuemei Wang, Brian D. Badgwell, Paul F. Mansfield, Woo-Jin Hyung, Vivian E. Strong, Yuko Kitagawa
Summary: This study aims to evaluate the impact of minimally invasive proximal gastrectomy (MIPG) on postoperative quality of life in patients with proximal gastric and gastroesophageal junction (P/GEJ) cancers. The study will compare the differences in postoperative appetite level, reflux condition, and quality of life between MIPG and minimally invasive total gastrectomy (MITG). A total of 60 patients are expected to be recruited, and the surgical procedures and anti-reflux techniques will be chosen based on patients' or surgeons' preferences. Assessments include appetite level, body weight, biochemical markers, and quality of life questionnaires. The expected outcome of this study is to establish the benefits and safety of MIPG.
Article
Multidisciplinary Sciences
Chang Min Lee, Sungsoo Park, Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim
Summary: A comparison between laparoscopic gastrectomy using ALIs and robotic gastrectomy was conducted, revealing that laparoscopic gastrectomy using ALIs showed similar perioperative outcomes and a shorter operation time compared to robotic gastrectomy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Surgery
Sejin Lee, Jeong Ho Song, Sung Hyun Park, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim
Summary: In this study, the intracorporeal modified delta-shaped gastroduodenostomy technique was safely performed via a 2-port approach, resulting in acceptable surgical outcomes and no major complications.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)