Article
Microbiology
Cai Zhiling, Mo Zitong, Zheng Shiqian, Lan Shihua, Xie Shengjun, Lu Jinghui, Tang Chunping, Shen Zhibin
Summary: This study reports a promising combination therapy of flavaspidic acid BB and mupirocin, which can effectively eradicate Staphylococcus epidermidis biofilm and eliminate its drug resistance. The combination therapy shows synergistic effects in inhibiting planktonic bacteria and biofilm formation, possibly due to the adhesion between bacteria. This research provides experimental data for the clinical treatment of skin infections and demonstrates the potential of BB as a novel biofilm inhibitor.
Article
Biochemistry & Molecular Biology
Denis Swolana, Malgorzata Kepa, Celina Kruszniewska-Rajs, Robert D. Wojtyczka
Summary: Nanosilver has an impact on biofilm formation, gene expression, and viability of Staphylococcus epidermidis. Low concentrations of nanosilver may increase biofilm production, while high concentrations do not have this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Bingjie Wang, Qing Zhan, Yanghua Xiao, Yanlei Xu, Huilin Zhao, Lulin Rao, Xinyi Wang, Jiao Zhang, Li Shen, Ying Zhou, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Fangyou Yu
Summary: Mupirocin stimulates the biofilm formation of Staphylococcus epidermidis by accelerating autolysis and eDNA release, depending on the specific gene atlE.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Andrej Minich, Zdenko Levarski, Maria Mikulasova, Marek Straka, Adriana Liptakova, Stanislav Stuchlik
Summary: The study showed that natural phenolic compounds vanillin and syringic acid have similar biofilm and extracellular polymer substance (EPS) inhibition effects on different genotypes of methicillin-resistant S. epidermidis strains. They effectively reduce biofilm formation and EPS content, making them potential inhibitors of biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Tao Li, Yan Lu, Hua Zhang, Lei Wang, Ross C. Beier, Yajie Jin, Wenjing Wang, Huanrong Li, Xiaolin Hou
Summary: Aloe-emodin demonstrates promising antimicrobial activity against Gram-positive bacteria, particularly Staphylococcus epidermidis. Its mechanism of action involves disrupting cell morphology and selective membrane permeability, affecting protein synthesis and biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yixin Jin, Qichen Wang, Haomin Zhang, Na Zhao, Ziyu Yang, Hua Wang, Min Li, Qian Liu
Summary: Staphylococcus epidermidis, a human commensal, can form biofilm and cause invasive infections. Our study found that S. epidermidis isolates from different infection sites exhibited different biofilm forming capacity. Isolates from sterile body fluid showed thicker biofilm and expressed higher levels of accumulation-associated protein. The increased expression of certain proteins may contribute to the dispersal of bacteria from biofilm and subsequent spread.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Chisato Takahashi, Mari Sato, Chikara Sato
Summary: Staphylococcus epidermidis, a gram-positive bacterium, plays an important role in biofilm formation and microvesicle secretion. This study successfully imaged the microvesicles secreted by Staphylococcus epidermidis and their integration into biofilms using atmospheric scanning electron microscopy (ASEM). The information obtained is expected to help elucidate the biological mechanism of biofilm formation and develop medicines against biofilms and associated infections.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Microbiology
Shihua Lan, Xiaofeng Chen, Chuanping Yin, Shengjun Xie, Shuaishuai Wang, Rongrong Deng, Zhibin Shen
Summary: Research found that Disaspidin BB obtained from plant extracts and purifications has inhibitory effect on drug-resistant Staphylococcus epidermidis biofilms, and its mechanism of anti-biofilm activity was preliminarily investigated.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Kidon Sung, Miseon Park, Jungwhan Chon, Ohgew Kweon, Saeed A. Khan, Andrew Shen, Angel Paredes
Summary: This study investigates the effect of subinhibitory concentrations of tigecycline on biofilms formed by Staphylococcus epidermidis strain RP62A. The results show that different concentrations of tigecycline can cause changes in biofilm production and significantly affect protein expression. The study suggests that analyzing the global protein expression profile of biofilm cells under antibiotic pressure can improve our understanding of the mechanisms of antibiotic resistance.
Article
Microbiology
Yongqi Mu, Hong Zeng, Wei Chen
Summary: Quercetin exhibits anti-biofilm activity against Staphylococcus epidermidis by reducing cell surface hydrophobicity and inhibiting polysaccharide intercellular adhesin production, indicating its potential as an anti-biofilm agent for biofilm infections caused by S. epidermidis and potentially other bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Ranjith Konduri, Chinthala Reddy Saiabhilash, Sisinthy Shivaji
Summary: The study revealed that Staphylococcus aureus and Staphylococcus epidermidis isolated from patients with Endophthalmitis have the potential to form biofilms, with faster formation on corneas and dispersal phase occurring within 48 hours. Biofilm formation renders the bacteria several-fold more resistant to antibiotics compared to planktonic cells.
Article
Immunology
Johanna Stamm, Samira Weisselberg, Anna Both, Antonio Virgilio Failla, Gerhard Nordholt, Henning Buettner, Stefan Linder, Martin Aepfelbacher, Holger Rohde
Summary: This study explores the effect of growth media on the biofilm formation of Staphylococcus epidermidis. By utilizing an artificial synovial fluid (ASF) medium that mimics the conditions encountered during host invasion, the researchers found that ASF induces the formation of biofilm and cluster in S. epidermidis. Gene expression analysis also revealed changes in the expression of genes related to adhesion and autolysis. These findings suggest the importance of using growth media that mimic host environments for future studies on the pathogenesis of S. epidermidis prosthetic joint infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
P. Kasparova, E. Vankova, L. Brazdova, K. Lokocova, O. Matatkova, J. Masak
Summary: Pterostilbene (PTE) is a natural compound with antioxidant and antimicrobial properties, which can enhance the effectiveness of erythromycin and tetracycline in inhibiting the growth and biofilm formation of Staphylococcus epidermidis. PTE was found to effectively inhibit S. epidermidis, reduce metabolic activity of biofilm cells, and enhance the action of antibiotics in overcoming biofilm cell tolerance.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Laurine Kaul, Adrian I. Abdo, Tom Coenye, Bastiaan P. Krom, Michel A. Hoogenkamp, Andrew C. W. Zannettino, Regine Suess, Katharina Richter
Summary: This study describes the antibacterial properties of a combination treatment of diethyldithiocarbamate (DDC) and copper ions (Cu2+), which showed synergistic and additive effects against planktonic and biofilm cultures of Staphylococcus aureus and Staphylococcus epidermidis, with low cytotoxicity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jiaxue Wang, Lulin Rao, Zhuoan Huang, Lili Ma, Tian Yang, Zhongqi Yu, Aihua Sun, Yumei Ge
Summary: The current study investigates the impact of the nitric oxide synthase (NOS) gene on biofilm formation in Staphylococcus epidermidis (S. epidermidis). The results show that deletion of the NOS gene enhances biofilm formation, slightly retards bacterial growth, decreases autolysis rate, and weakens bacterial biofilm dispersal. Gene expression analysis suggests that the NOS gene negatively regulates biofilm formation by affecting biofilm aggregation and dispersal.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Danielle C. Brito, Sheyla F. S. Domingues, Joyce K. Silva, Xueqing Wu, Regiane R. Santos, Julio C. Pieczarka
BIOPRESERVATION AND BIOBANKING
(2016)
Article
Immunology
Faidad Khan, Xueqing Wu, Gideon L. Matzkin, Mohsin A. Khan, Fuminori Sakai, Jorge E. Vidal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2016)
Article
Agriculture, Dairy & Animal Science
W. Kissels, X. Wu, R. R. Santos
JOURNAL OF DAIRY SCIENCE
(2017)
Article
Reproductive Biology
D. C. C. Brito, S. F. S. Domingues, A. P. R. Rodrigues, C. Maside, F. O. Lunardi, X. Wu, J. R. Figueiredo, J. C. Pieczarka, R. R. Santos
Article
Microbiology
Santiago M. Lattar, Xueqing Wu, Jennifer Brophy, Fuminori Sakai, Keith P. Klugman, Jorge E. Vidal
Article
Microbiology
Priyanka Pundir, Rui Liu, Chirag Vasavda, Nadine Serhan, Nathachit Limjunyawong, Rebecca Yee, Yingzhuan Zhan, Xintong Dong, Xueqing Wu, Ying Zhang, Solomon H. Snyder, Nicolas Gaudenzio, Jorge E. Vidal, Xinzhong Dong
CELL HOST & MICROBE
(2019)
Article
Infectious Diseases
P. Zhang, Q. Shi, H. Hu, B. Hong, X. Wu, X. Du, M. Akova, Y. Yu
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Article
Microbiology
Xueqing Wu, Oren Gordon, Wenxin Jiang, Brenda S. Antezana, Uriel A. Angulo-Zamudio, Carlos del Rio, Abraham Moller, Terry Brissac, Aimee R. P. Tierney, Kurt Warncke, Carlos J. Orihuela, Timothy D. Read, Jorge E. Vidal
JOURNAL OF BACTERIOLOGY
(2019)
Article
Infectious Diseases
Lingyan Sun, Yan Chen, Xiaoting Hua, Yiyi Chen, Jinjing Hong, Xueqing Wu, Yan Jiang, Willem van Schaik, Tingting Qu, Yunsong Yu
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Immunology
Tyler V. V. Gregory, Karen Ellis, Renzo Valeriani, Faidad Khan, Xueqing Wu, Landon Murin, Babek Alibayov, Ana G. Jop Vidal, Tong Zhao, Jorge E. E. Vidal
Summary: The MoWa mixture is effective in killing both MRSA and MSSA strains of Staphylococcus aureus, disinfecting contaminated surfaces and eradicating important nosocomial pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Xueqing Wu, Shanshan Zhao, Yan Jiang, Xi Xiang, Lihong Ge, Qiong Chen, Yanfei Wang, Jorge E. Vidal, Yunsong Yu
Summary: This study evaluated the impact of interrupted PCV availability on pneumococcal pneumonia and genetic variation of Streptococcus pneumoniae. The findings showed that interrupted PCV availability affected the prevalence of pneumococcal disease and pneumococcal genome variation.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Tao Lou, Xiaoxing Du, Ping Zhang, Qiucheng Shi, Xinhong Han, Peng Lan, Rushuang Yan, Huangdu Hu, Yanfei Wang, Xueqing Wu, Yan Jiang, Yunsong Yu
Summary: This study aimed to predict the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and provide clinicians with better methods to identify the infection at an early stage. The results showed that longer hospital stay, stay in the intensive care unit, previous exposure to antibacterial agents, invasive procedures, use of intravascular catheters, and other factors were risk factors for CRKP infection. Carbapenem exposure was found to be a common predictor for different types of CRKP infection. The 28-day crude mortality of CRKP infection was independently associated with sex, admitted unit, and type of infection.
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Yan Jiang, Ying Zhang, Jun Lu, Qihui Wang, Yushan Cui, Yanfei Wang, Jingjing Quan, Dongdong Zhao, Xiaoxing Du, Haiyang Liu, Xi Li, Xueqing Wu, Xiaoting Hua, Ye Feng, Yunsong Yu
Article
Developmental Biology
D. C. C. Brito, S. F. S. Domingues, A. P. R. Rodrigues, L. M. Silva, K. A. Alves, X. Wu, T. S. Francisco, I. L. Barroso Neto, V. N. Freire, J. R. Figueiredo, J. C. Pieczarka, R. R. Santos
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)
Article
Biotechnology & Applied Microbiology
Xueqing Wu, Nathan T. Jacobs, Catherine Bozio, Preston Palm, Santiago M. Lattar, Christiane R. Hanke, David M. Watson, Fuminori Sakai, Bruce R. Levin, Keith P. Klugman, Jorge E. Vidal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2017)