Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway

Hypertension with diabetes mellitus: physiology and pathology

(2018) Mitsuru Ohishi   HYPERTENSION RESEARCH

Effects of metformin on blood pressure in nondiabetic patients

(2017) Long Zhou et al.   JOURNAL OF HYPERTENSION

Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

(2017) Mahdi Hamidi Shishavan et al.   Scientific Reports

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular DysfunctionHighlights

(2016) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metformin attenuates fluctuating glucose-induced endothelial dysfunction through enhancing GTPCH1-mediated eNOS recoupling and inhibiting NADPH oxidase

(2016) Huijie An et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats

(2015) Melissa A. Linden et al.   Applied Physiology Nutrition and Metabolism

Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

(2015) Jia Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ethanol extract of Remotiflori radix induces endoplasmic reticulum stress-mediated cell death through AMPK/mTOR signaling in human prostate cancer cells

(2015) Aeyung Kim et al.   Scientific Reports

Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5′ Adenosine Monophosphate–Activated Protein Kinase–Peroxisome Proliferator–Activated Receptor δ Pathway

(2014) Wai San Cheang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats

(2014) Chih-Min Tsai et al.   Translational Research

NADPH Oxidases in Vascular Pathology

(2013) Anna Konior et al.   ANTIOXIDANTS & REDOX SIGNALING

Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-α2 In Vivo

(2013) Bin Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Seung-Lark Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Do intravenous and subcutaneous angiotensin II increase blood pressure by different mechanisms?

(2013) Duncan J Campbell   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes

(2013) Tae Woo Jung et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension

(2012) Naoko Deji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

(2012) D. Pitocco et al.   DIABETES OBESITY & METABOLISM

Endoplasmic reticulum stress and hypertension — a new paradigm?

(2012) Alyssa H. Hasty et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin-based treatment for obesity-related hypertension

(2012) Hongbo He et al.   JOURNAL OF HYPERTENSION

Interleukin-10 Released by CD4 + CD25 + Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice

(2011) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent

(2010) Rebecca J. Ford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin induces suppression of NAD(P)H oxidase activity in podocytes

(2010) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION