Defining TP53 pioneering capabilities with competitive nucleosome binding assays

Two p53 tetramers bind one consensus DNA response element

(2016) Sinéad Kearns et al.   NUCLEIC ACIDS RESEARCH

Chromatin structure-dependent conformations of the H1 CTD

(2016) He Fang et al.   NUCLEIC ACIDS RESEARCH

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca 2+ or Mg 2+ at Millimolar Concentrations

(2015) Agato Murata et al.   JOURNAL OF MOLECULAR BIOLOGY

The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

(2015) Oleg Laptenko et al.   MOLECULAR CELL

Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes

(2014) Isha Sethi et al.   BMC GENOMICS

Pioneer transcription factors in cell reprogramming

(2014) Makiko Iwafuchi-Doi et al.   GENES & DEVELOPMENT

TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity

(2014) Morgan A. Sammons et al.   GENOME RESEARCH

Chromatin accessibility: a window into the genome

(2014) Maria Tsompana et al.   Epigenetics & Chromatin

Nucleosomes accelerate transcription factor dissociation

(2013) Y. Luo et al.   NUCLEIC ACIDS RESEARCH

Using electrophoretic mobility shift assays to measure equilibrium dissociation constants: GAL4-p53 binding DNA as a model system

(2012) Michael A. Heffler et al.   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

ArchTEx: accurate extraction and visualization of next-generation sequence data

(2012) William K. M. Lai et al.   BIOINFORMATICS

Standardized collection of MNase-seq experiments enables unbiased dataset comparisons

(2012) Jason M Rizzo et al.   BMC MOLECULAR BIOLOGY

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

(2012) T. K. Kelly et al.   GENOME RESEARCH

Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements

(2012) Abdul S. Ethayathulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

(2012) Karolin Luger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin architectures at fission yeast transcriptional promoters and replication origins

(2012) Robert M. Givens et al.   NUCLEIC ACIDS RESEARCH

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

(2012) A. S. Ethayathulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sliding of p53 along DNA Can Be Modulated by Its Oligomeric State and by Cross-Talks between Its Constituent Domains

(2011) Netaly Khazanov et al.   JOURNAL OF MOLECULAR BIOLOGY

p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation

(2011) Hyunjung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element

(2011) S. Emamzadah et al.   MOLECULAR CANCER RESEARCH

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

(2011) O. Laptenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ArchAlign: Coordinate-free chromatin alignment reveals novel architectures

(2011) William Lai et al.   GENOME BIOLOGY

p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy

(2010) E. Lidor Nili et al.   GENOME RESEARCH

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

A single-molecule characterization of p53 search on DNA

(2010) A. Tafvizi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA

(2009) T. Sekiya et al.   GENES & DEVELOPMENT

p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element

(2009) Geetaram Sahu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts

(2009) Maher A. Noureddine et al.   PLoS Genetics

Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability

(2008) Anahita Tafvizi et al.   BIOPHYSICAL JOURNAL

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

(2008) Dmitry B. Veprintsev et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a p53 core tetramer bound to DNA

(2008) K A Malecka et al.   ONCOGENE