Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3 + T regs

Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice

(2013) Andrea Annoni et al.   EMBO Molecular Medicine

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Immune responses in liver-directed lentiviral gene therapy

(2013) Andrea Annoni et al.   Translational Research

ZnT8 Is a Major CD8+ T Cell-Recognized Autoantigen in Pediatric Type 1 Diabetes

(2012) E. Enee et al.   DIABETES

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

(2011) A. Biffi et al.   BLOOD

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62LloFoxP3+CD4+ T cells with limited suppressor activity

(2011) Kevin S. Goudy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

(2011) Janka Mátrai et al.   HEPATOLOGY

Inducible Adeno-Associated Virus-Mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes

(2011) K. S. Goudy et al.   JOURNAL OF IMMUNOLOGY

Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

(2011) C. Kuhn et al.   Science Translational Medicine

Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy

(2011) Kevin Scott Goudy et al.   Frontiers in Microbiology

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ

(2010) G. Fousteri et al.   DIABETOLOGIA

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice

(2010) Devangi S. Mehta et al.   IMMUNOLOGY

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

(2009) A. Annoni et al.   BLOOD

Integrase-defective lentiviral vectors: progress and applications

(2009) M B Banasik et al.   GENE THERAPY

Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3− regulatory T cells suppressing autoimmune hepatitis

(2009) Nils Kruse et al.   HEPATOLOGY

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

(2009) Ekaterina Breous et al.   HEPATOLOGY

CD8+ T cell tolerance following antigen recognition on hepatocytes

(2009) Lauren E. Holz et al.   JOURNAL OF AUTOIMMUNITY

Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

(2009) Damien Bresson et al.   MOLECULAR THERAPY

T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects

(2008) Jeffrey A. Bluestone et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic Stellate Cells Preferentially Expand Allogeneic CD4+CD25+FoxP3+ Regulatory T Cells in an IL-2-Dependent Manner

(2008) Guoping Jiang et al.   TRANSPLANTATION

Gene delivery GAD500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: Transduction efficiency do not play important roles

(2007) Gencheng Han et al.   IMMUNOLOGY LETTERS