Review
Pathology
Lin Yuan, Tsung-Teh Wu, Lizhi Zhang
Summary: Microscopic colitis (MC) is a chronic inflammatory disease of the colon characterized by chronic, watery, nonbloody diarrhea and normal or almost normal endoscopic findings. Two main subtypes of MC, lymphocytic colitis (LC) and collagenous colitis (CC), are identified through microscopic examination on colon biopsy. The pathogenesis of MC is still unclear, but it has been associated with various risk factors and other diseases such as celiac disease, inflammatory bowel disease, and medication use. This paper aims to provide a systematic introduction to the clinicopathologic features of MC, focusing on unusual features and associations with other conditions.
Article
Obstetrics & Gynecology
Marthe S. Gottschalk, Anne Eskild, Solveig Hofvind, Elisabeth K. Bjelland
Summary: A study in Norway found that age at natural menopause increases with increasing number of childbirths up to three, but does not further increase beyond three childbirths. This suggests a complex relationship between childbirth and menopause age.
HUMAN REPRODUCTION
(2022)
Article
Gastroenterology & Hepatology
Johanna Kristina Larsson, Spencer Clarkson, Klas Sjoberg
Summary: The incidence of microscopic colitis (MC) has been increasing in the southern region of Sweden over the past decades. This study aimed to determine the incidence of lymphocytic colitis (LC) and collagenous colitis (CC) in the county of Skane during the period of 2010-2020, with a focus on temporal and spatial variations. The diagnosis of MC was retrieved from biopsy registries, and established diagnostic criteria were used. The study identified 1985 patients, with stable incidence of CC and a significant increase in the incidence of LC, particularly in the northwest region of Skane.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Hamed Khalili, Jordan E. Axelrad, Bjorn Roelstraete, Ola Olen, Mauro D'Amato, Jonas F. Ludvigsson
Summary: The study reveals that gastrointestinal infections are associated with an increased risk of microscopic colitis, especially Clostridioides difficile. The association between gastrointestinal infections and risk of MC is stronger for the collagenous subtype.
Review
Medicine, General & Internal
Emese Mihaly, Arpad Patai, Zsolt Tulassay
Summary: Microscopic colitis (MC) is increasingly recognized, but there are still many unanswered questions regarding its pathogenesis, diagnosis, and therapy. The relationship between microbiome changes, different subtypes of the disease, and the effectiveness of treatments like budesonide and biologics remain unclear, highlighting the need for further research in the future.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Alberto Fernandez-Pena, Francisco J. Navas-Sanchez, Daniel Martin de Blas, Luis Marcos-Vidal, Manuel Desco, Susanna Carmona
Summary: Surgical menopause causes cortical atrophy, while parity may mitigate the impact.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Jie Lin, Qian Xie, Chaoran Xu, Qin Wan
Summary: This study found that the prevalence of obesity in Chinese women over 40 years of age increased gradually with an increasing number of live births. Premenopausal women had slightly higher rates of obesity and overweight compared to postmenopausal women. In addition, the risk of obesity increased with an increasing number of live births in women with systolic blood pressure < 121 mmHg or current smoking.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Pathology
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Danny Goudkade, Jeppe Thagaard, Henrik Holten-Rossing, Stefania Landolfi, Vincenzo Villanacci, Lars Kristian Munck
Summary: Microscopic colitis (MC) encompasses lymphocytic colitis (LC) and collagenous colitis (CC). LC often presents with thickening of the subepithelial collagen band, while CC is characterized by an increased number of intraepithelial T-lymphocytes (IELs). The essential histopathological feature of MC is considered to be the lymphocytic inflammatory infiltration of the mucosa, although there is a non-linear correlation between the number of IELs and thickness of the collagenous band, indicating differences in their pathogenesis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jean Shin, Kyungdo Han, Jin Hyung Jung, Hyo Jin Park, Wonsock Kim, Youn Huh, Yang Hyun Kim, Do Hoon Kim, Seon Mee Kim, Youn Seon Choi, Kyung Hwan Cho, Ga Eun Nam
Summary: This study suggests that postmenopausal women with a history of premature menopause or early menopausal age may have an increased risk of heart failure and atrial fibrillation. These reproductive factors need to be considered for preventing future risks of heart failure and atrial fibrillation.
EUROPEAN HEART JOURNAL
(2022)
Review
Endocrinology & Metabolism
Xiao Zhang, Zhao Huangfu, Shaowei Wang
Summary: Earlier age at natural menopause (ANM) is associated with adverse outcomes such as osteoporosis, cardiovascular disease, and cancer. Mendelian randomization (MR) studies have revealed that factors such as higher body mass index, poor educational level, early age at menarche, and autoimmune thyroid disease are involved in the etiology of early ANM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Elvin S. Cheng, Louiza S. Velentzis, Marianne Weber, Julia Steinberg, Karen Canfell, Xue Qin Yu
Summary: There is emerging evidence suggesting that oestrogen may be involved in lung cancer development, especially among never-smoking women. A large-scale study in China found that factors such as age at menarche, age at menopause, time since menopause, prior use of oral contraceptives, number of livebirths, breastfeeding, and age at first livebirth were associated with increased risk of lung cancer death among never-smoking women. These findings highlight the potential role of reproductive factors in lung cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Samuel W. Chey, Maria Westerhoff, William D. Chey
Summary: This is the first scientific report to describe lymphocytic colitis as a potential adverse event following administration of the Pfizer mRNA vaccine for COVID-19. The patient experienced persistent symptoms including diarrhea, abdominal pain, and nausea for 3 months after receiving the second dose, but showed improvement after 113 days. The report also identified additional cases of microscopic colitis in the Vaccine Adverse Event Reporting System, suggesting that providers should consider this condition as a possible diagnosis for patients with severe, persistent diarrhea after the SARS-CoV2 mRNA vaccine.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xiaoyan Sun, Rui Zhang, Lirong Wang, Xiping Shen, Yongbin Lu, Junxia An, Liyan Wang, Yiqing Wang, Xiaorong Luo, Haiying Zhu, Xuehong Zhang
Summary: The study in Gansu province found no relationship between parity and age at menopause among Chinese women, but noted that nulliparity or multiparity may increase the risk of menopausal syndrome, with potential benefits observed in women with 1 or 2 births.
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Tracy Butler, Lidia Glodzik, Xiuyuan Hugh Wang, Ke Xi, Yi Li, Hong Pan, Liangdong Zhou, Gloria Chia-Yi Chiang, Simon Morim, Nimmi Wickramasuriya, Emily Tanzi, Thomas Maloney, Patrick Harvey, Xiangling Mao, Qolamreza Ray Razlighi, Henry Rusinek, Dikoma C. Shungu, Mony de Leon, Craig S. Atwood, P. David Mozley
Summary: Hypothalamic inflammation plays a crucial role in aging and age-related diseases in rodents. This study assessed hypothalamic inflammation in humans using PET and found a different pattern of inflammation compared to rodents. Specifically, age-correlated hypothalamic inflammation was observed only in women, which may be relevant to understanding menopause and reproductive aging in women.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Sven E. Ojavee, Liza Darrous, Marion Patxot, Kristi Lall, Krista Fischer, Reedik Magi, Zoltan Kutalik, Matthew R. Robinson
Summary: There is currently little evidence of significant variation in the genetic basis of human phenotype across the lifespan. However, a study on age at natural menopause (ANM) in the UK Biobank found that a substantial number of genetic associations with ANM showed an age-specific effect. These findings suggest the importance of understanding the age dependency of genetic risk factors in relation to health indicators and outcomes.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Po-Hong Liu, Amit G. Singal, Caitlin C. Murphy
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Wenjie Ma, Marjorie M. Walker, Marcus Thuresson, Bjorn Roelstraete, Filip Skoldberg, Ola Olen, Lisa L. Strate, Andrew T. Chan, Jonas F. Ludvigsson
Summary: This study found that patients with diverticular disease who have colorectal histopathology have a 33% increased risk of overall incident cancer, with specific increases in colon, liver, pancreatic, and lung cancers.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Pediatrics
Jonas F. Ludvigsson, Jan Adolfsson, Malin Hoistad, Per-Anders Rydelius, Berit Kristroem, Mikael Landen
Summary: This systematic review aims to assess the effects of hormone treatment on psychosocial and mental health, cognition, body composition, and metabolic markers in children with gender dysphoria. The review identified 24 relevant English-language studies, but the evidence was insufficient to evaluate the effects of hormone therapy in these areas. Further research is needed to better understand the impacts of hormone treatment in children with gender dysphoria.
Editorial Material
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Jonas F. Ludvigsson
Summary: This article is related to the papers by Kang et al. To access these articles, please visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Hannes Hagstroem, Jonas F. F. Ludvigsson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Bjorn Roelstraete, Hamed Khalili, Jonas F. Ludvigsson
Summary: This study examined the association between type 1 diabetes (T1D) and microscopic colitis (MC). The results showed that the prevalence of T1D was almost 80% higher in MC patients compared to the general population. This association may be related to the consumption of medications associated with MC onset.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Haley M. Zylberberg, Benjamin Lebwohl, Bjorn Roelstraete, Jonas Soederling, Olof Stephansson, Peter H. R. Green, Jonas F. Ludvigsson
Summary: This study aimed to investigate the risk of cardiac birth defects in infants born to mothers with celiac disease (CeD). The results showed no statistically significant association between maternal CeD and the risk of any or cardiac birth defects in the offspring, compared to the general population and non-affected siblings.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Surgery
Andreas Wallhuss, Johan Ottosson, Yang Cao, Ellen Andersson, Daniel Bergemalm, Carl Eriksson, Ola Olen, Eva Szabo, Erik Stenberg
Summary: This study aimed to evaluate the safety and effectiveness of bariatric surgery in obese patients with inflammatory bowel disease. The results showed that sleeve gastrectomy was a safe and effective option for weight loss in patients with both Crohn's disease and ulcerative colitis, while Roux-en-Y gastric bypass was associated with a higher risk of postoperative complications in patients with ulcerative colitis.
Correction
Public, Environmental & Occupational Health
J. F. Ludvigsson, P. Appelros, J. Askling
CLINICAL EPIDEMIOLOGY
(2023)
Review
Behavioral Sciences
Erland Axelsson, Dorian Kern, Erik Hedman-Lagerlof, Perjohan Lindfors, Josefin Palmgren, Hugo Hesser, Erik Andersson, Robert Johansson, Ola Olen, Marianne Bonnert, Maria Lalouni, Brjann Ljotsson
Summary: This systematic review and meta-analysis examined the effects of various psychological treatments on irritable bowel syndrome (IBS). The results showed that exposure therapy and hypnotherapy had significant additional effects compared to attention controls. Exposure therapy was found to be a particularly promising treatment for IBS.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Gastroenterology & Hepatology
Asa Everhov, Jonas Soederling, Gustaf Befrits, Hamed Khalili, Gabriella Broems, Martin Neovius, Johan Askling, Jonas F. Halfvarson, Jonas Ludvigsson, Ola Olen, SWIBREG Study Group
Summary: This study assessed the costs of prevalent Crohn's disease (CD) or ulcerative colitis (UC) patients in Sweden from 2007 to 2020, including productivity losses. The study found that in recent years, the costs of patients mainly came from healthcare costs, rather than productivity losses. Particularly, the use of biologics contributed to the increase in healthcare costs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
David Bergman, Bjorn Roelstraete, Jiangwei Sun, Fahim Ebrahimi, Johan Askling, Jonas F. Ludvigsson
Summary: A study found that there is an association between microscopic colitis (MC) and rheumatoid arthritis (RA), with MC patients being nearly twice as likely to develop RA compared to the general population. This study is important as it highlights the need for expedited evaluation for RA in MC patients presenting with joint symptoms and/or arthralgia, thus preventing delay in RA diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Kyle Staller, Ola Olen, Jonas Soderling, Bjorn Roelstraete, Hans Tornblom, Braden Kuo, Long H. Nguyen, Jonas F. Ludvigsson
Summary: The study found that previous use of antibiotics was associated with an increased risk of developing irritable bowel syndrome (IBS), particularly among those with multiple antibiotic dispensations.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Medicine, General & Internal
Weiyao Yin, Jonas F. Ludvigsson, Ulrika Aden, Kari Risnes, Martina Persson, Abraham Reichenberg, Michael E. Silverman, Eero Kajantie, Sven Sandin
Summary: This study investigated the association between psychiatric diagnoses in fathers, mothers, and both parents and gestational age. The results showed that both paternal and maternal psychiatric diagnoses were associated with earlier gestational age, and the risk increased when both parents were diagnosed. The risk also increased when fathers and mothers were diagnosed with different psychiatric disorders. These findings suggest that the presence of psychiatric diagnoses in parents impacts gestational age at birth.
