Journal
FOOD CHEMISTRY
Volume 272, Issue -, Pages 141-147Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.08.002
Keywords
Point-of-use detection; Smartphone-based system; Multivariate optimization; Vitamin C quantification; Orange juice; Vitamin C supplements
Funding
- National Science Foundation [CBET 12-64377]
- Generalitat Valenciana (Spain) [APOSTD/2016/076]
- European Social Fund (ESF)
- Ruth L. Kirschstein Pre-Doctoral Fellowship [NIH F30AI122925]
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A rapid and portable analytical methodology has been developed for ascorbic acid (Vitamin C) quantification from aqueous samples using a spectrometric smartphone-based system for the first time. The method employs point-of-use approaches both for sample preparation and sample measurement, demonstrating the capability for mobile quality control of pharmaceutical and food products. Our approach utilizes an oxidation-reduction reaction between ascorbic acid and methylene blue, followed by a dispersive liquid-liquid microextraction (DLLME) to extract the aqueous-phase methylene blue into organic media. Then, a back-extraction procedure is employed to transfer the methylene blue to aqueous media, followed by analysis of the sample's absorption spectrum using the spectrometric smartphone-based system. The DLLME and back-extraction procedures are optimized by use of a two-step multivariate optimization strategy. Finally, vitamin C supplements and orange juice are used as real-world samples to assess the applicability of the smartphone-based method, which is successfully compared with the standard laboratory-based approach.
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