Article
Chemistry, Applied
Shi Shen, Xi Chen, Qin Zhuo, Yan Ma, Jingbo Wang, Liyuan Wang, Zhaolong Gong, Junsheng Huo
Summary: By applying untargeted and targeted metabolite analysis, differences in metabolites and compound contents among kiwifruits from different cultivars were found, which can benefit scientific research and new cultivar breeding.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agricultural Engineering
Shila Neel, Abhishek Mandal, Anirban Dutta, Supradip Saha, Amrita Das, Gautam Chawla, Aditi Kundu
Summary: Optimal extraction conditions for bioactive phytochemicals from black cumin seeds were determined by response surface methodology. The ethanolic concentrate exhibited excellent antifungal action against different strains of Aspergillus flavus, inhibiting fungal ergosterol content. Nigellamine A1, kaempferol-3-O-pentoside, and nigellidine-4-O-sulfite showed promising interactions with the target protein.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Food Science & Technology
Kun Dai, Yingying Wei, Shu Jiang, Feng Xu, Hongfei Wang, Xin Zhang, Xingfeng Shao
Summary: Thinned peach polyphenols (TPPs) were extracted and purified, and they exhibited high antioxidant, hypoglycemic, and hypolipidemic capacities. TPPs inhibited the activities of alpha-amylase and alpha-glucosidase, and showed a higher binding capacity for bile acids.
Article
Multidisciplinary Sciences
Lucia Pappalardo
Summary: Pomegranate is a valuable source of nutrition with medicinal benefits. As the demand for pomegranate fresh fruit juices increases, the issue of adulteration becomes a concern. This study utilized UV-visible spectroscopy and multivariate statistical analysis to detect adulteration of pomegranate juice with apple juice concentrate.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Jieyao Yuan, Vaidhyanathan Anantharamkrishnan, Thomas R. Hoye, Gary A. Reineccius
Summary: Thermal processing is a critical step for ensuring the microbial safety of our food. This study investigated the covalent reactions between beta-lactoglobulin (BLG) and 46 flavor compounds under pasteurization and sterilization conditions. The results showed that the reactions between flavor compounds and BLG were accelerated under higher thermal treatment conditions and some flavor compounds exhibited reactivity not previously observed at room temperature. These findings are important for understanding the interactions between flavor compounds and proteins during food processing.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zi-Meng Zhou, Dong-Mei Yan, Yi-Kun Wang, Ting Zhang, Xue-Rong Xiao, Man-Yun Dai, Shou-Wen Zhang, Hong-Ning Liu, Fei Li
Summary: Raspberry, a traditional Chinese medicine for nourishing kidney and strengthening Yang-qi, contains components that can improve renal function. Research showed that these components were absorbed into the blood and demonstrated kidney-protecting activity. Raspberry from Dexing, Jiangxi province, was found to have higher levels of key components compared to raspberries from other regions.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Huaqi Gao, Meimei Guo, Liqin Wang, Cui Sun, Lingxia Huang
Summary: This study analyzed the qualitative composition of free and bound phenolics in six varieties of mulberry seeds and found that mulberry seeds have abundant phenolic compounds. The study also revealed a correlation between phenolic content and antioxidant capacity, with higher content of free phenolics in mulberry seeds. This research provides a theoretical basis for the utilization of mulberry seeds.
Article
Biochemistry & Molecular Biology
Mirtha Navarro-Hoyos, Elizabeth Arnaez-Serrano, Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper
Summary: This study analyzed the compounds found in Physalis peruviana fruits and husks from Costa Rica using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. A total of 66 different compounds were identified. The results suggest that the husks and fruits of Physalis peruviana from Costa Rica may have potential health benefits.
Article
Immunology
Huiji Zhou, Luxian Zhou, Bo Li, Rongcai Yue
Summary: This study aimed to investigate the in vitro biological potency of Dendrobium officinale flowers (DOF) and screen its active components. The results showed that DOF extract has potential antioxidant capacity, anti-cyclooxygenase2 (COX-2) effect, anti-glycation potency, and anti-aging effects. A total of 34 compounds were identified using UPLC-ESI-QTOF-MS/MS, and the major potential antioxidants in DOF extract were determined through online ABTS radical analysis. Specific components in DOF and its active compound targeted related enzymes and highlighted their potential application in anti-aging.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang, Changhong Wang
Summary: This study aimed to clarify the metabolic pathway of Usnic acid (UA) and barbatic acid (BA) in lichen and their relationship with toxicity. The study found that hydroxylation, methylation, and glucuronidation reactions were involved in the metabolism of UA and BA. CYP2C9, CYP3A4, CYP2C8, and UGT1A1 were identified as key metabolic enzymes for UA, while CYP2C8, CYP2C9, CYP2C19, CYP1A1, UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 were identified for BA. UA and BA showed low cytotoxicity in human primary hepatocytes, but potential cytotoxicity to mouse 3T3 fibroblasts. The attenuated cytotoxicity of BA is associated with metabolism, while the cytotoxicity of UA may be related to chronic toxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Silvia Quesada-Mora, Gabriela Azofeifa-Cordero, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper, Mirtha Navarro-Hoyos
Summary: Curcuma longa rhizomes produced in Costa Rica contain a variety of polyphenols, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which have been found to possess important biological activities such as anti-inflammatory, antioxidant, anticancer, antimicrobial, antihypertensive, and anticoagulant effects. The study also demonstrates that the content of curcuminoids and antioxidant activity vary among different samples from different regions of Costa Rica.
Article
Plant Sciences
Gabriela Soledad Barragan-Zarate, Alfonso Alexander-Aguilera, Luicita Lagunez-Rivera, Rodolfo Solano, Ida Soto-Rodriguez
Summary: The study evaluated the effect of P. karwinskii leaf extract on metabolic syndrome components in Wistar rats, finding that a dose of 300 mg/kg reduced weight gain, fat deposits, and insulin resistance. The main bioactive compounds identified in the extract were quinic acid, neochlorogenic acid, chlorogenic acid, rutin, kaempferol-3-o-beta-rutinoside, and embelin, which exhibited MS-related bioactivity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Pathy Kibungu Kembelo, Emmy Tuenter, Wouter Vanhove, Honore Belesi Katulaa, Patrick Van Damme, Luc Pieters
Summary: This study conducted a phytochemical analysis of leaf extracts from Commelina africana and identified 22 compounds with antioxidant and anti-inflammatory properties, which may explain its traditional use for skin disorders.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Engineering, Chemical
Mirtha Navarro-Hoyos, Monica Acuna-Quiros, Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper
Summary: This study provides a detailed analysis of the polyphenolic profile, gingerol content, and antioxidant activity of Zingiber officinale Rhizomes produced in Costa Rica. The findings show that extracts from Costa Rican Z. officinale rhizomes have high levels of gingerols and exhibit strong antioxidant activity, making them valuable for potential health benefits and product development.
Article
Biochemistry & Molecular Biology
Yan Cheng, Xiaofang Ma, Qi Zhao, Chunyan Wang, Dongmei Yan, Fei Li
Summary: In this study, the metabolic characterizations of three C-PYCs, including MH, ISM, and MER, were determined using UPLC-ESI-QTOF-MS, revealing major metabolic pathways of hydroxylation, dehydrogenation, demethylation, and conjugation. MH exhibited lower metabolic rate compared to ISM and MER, impacting their bioactivities. Recombinant CYP screening implicated CYP1A1, 2B6, 3A4, and 3A5 as major metabolic enzymes involved in the formation of metabolites, which all showed anti-inflammatory activity.
