T-type calcium channel blockers: a patent review (2012–2018)

Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial

(2018) N. Kerckhove et al.   EUROPEAN JOURNAL OF PAIN

Synthesis of new N3- substituted dihydropyrimidine derivatives as L-/T- type calcium channel blockers

(2017) Mohamed Teleb et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss

(2017) Lu Sang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

(2017) Olivier Bezençon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calcium-channel blockers as therapeutic agents for acquired sensorineural hearing loss

(2017) James G. Naples   MEDICAL HYPOTHESES

Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys

(2016) Adriana Galvan et al.   ACS Chemical Neuroscience

Synthesis and evaluation of 6-pyrazoylamido-3 N -substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain

(2016) Jung Hyun Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment

(2016) Jung Hyun Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anatomical localization of Cav3.1 calcium channels and electrophysiological effects of T-type calcium channel blockade in the motor thalamus of MPTP-treated monkeys

(2016) Annaelle Devergnas et al.   JOURNAL OF NEUROPHYSIOLOGY

T-type calcium channels in neuropathic pain

(2016) Emmanuel Bourinet et al.   PAIN

Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers

(2016) YA-FENG YU et al.   Experimental and Therapeutic Medicine

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639

(2015) Qingwei Zhang et al.   ACS Medicinal Chemistry Letters

Characterization of Novel Cannabinoid Based T-Type Calcium Channel Blockers with Analgesic Effects

(2014) Chris Bladen et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model

(2014) Ju-Hyeon Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers

(2013) Jung-eun Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia

(2013) Michael F. Egan et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Analgesic Effect of a Mixed T-Type Channel Inhibitor/CB2 Receptor Agonist

(2013) Vinicius M Gadotti et al.   Molecular Pain

Functional Characterization and Analgesic Effects of Mixed Cannabinoid Receptor/T-Type Channel Ligands

(2012) Haitao You et al.   Molecular Pain

T-Type Calcium Channel as a New Therapeutic Target for Tremor

(2011) Hideto Miwa et al.   CEREBELLUM

T-type calcium channels inhibitors: a patent review

(2010) Fabrizio Giordanetto et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats

(2010) Hideto Miwa et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

(2008) Zhi-Qiang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of neuronal T-type calcium channels

(2008) Mircea C. Iftinca et al.   TRENDS IN PHARMACOLOGICAL SCIENCES