Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin-2-Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells

Bu-Zhong-Yi-Qi Decoction, the Water Extract of Chinese Traditional Herbal Medicine, Enhances Cisplatin Cytotoxicity in A549/DDP Cells through Induction of Apoptosis and Autophagy

(2017) Ning Yu et al.   Biomed Research International

Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation

(2016) Belinda Halling Sørensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin

(2016) Weili Li et al.   Cancer Cell International

Confluence-dependent resistance to cisplatin in lung cancer cells is regulated by transforming growth factor-beta

(2016) Saki Yokokura et al.   EXPERIMENTAL LUNG RESEARCH

Theaflavin-3, 3′-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells

(2016) YOUYING TU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Heterozygous p53V172F mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53

(2016) X Xie et al.   ONCOGENE

HSP27 Knockdown Increases Cytoplasmic p21 and Cisplatin Sensitivity in Ovarian Carcinoma Cells

(2016) Hao Lu et al.   ONCOLOGY RESEARCH

miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin

(2016) Xuesong Chen et al.   Scientific Reports

Green tea polyphenol EGCG reverse cisplatin resistance of A549/DDP cell line through candidate genes demethylation

(2015) Youwei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53 -Defective Tumors to Chemotherapy

(2015) Ian G. Cannell et al.   CANCER CELL

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

(2015) Weilin Wang et al.   CANCER LETTERS

A systematic review of anticancer effects of Radix Astragali

(2015) Yeehong Jung et al.   Chinese Journal of Integrative Medicine

Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials

(2015) Yanhong Lv et al.   Evidence-based Complementary and Alternative Medicine

An in vivo and in vitro study

(2015) C Wang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Influence of reducing agents on the cytotoxic activity of platinum(iv) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

(2015) Verena Pichler et al.   Metallomics

Acetylenes and fatty acids from Codonopsis pilosula

(2015) Yueping Jiang et al.   Acta Pharmaceutica Sinica B

Mitofusin 2-Deficiency Suppresses Cell Proliferation through Disturbance of Autophagy

(2015) Yanhong Ding et al.   PLoS One

Shenqi Fuzheng Injection (参芪扶正注射液) for advanced gastric cancer: A systematic review of randomized controlled trials

(2014) Jiang Li et al.   Chinese Journal of Integrative Medicine

Shenqifuzheng injection combined with chemotherapy in the treatment of advanced gastric cancer: A systematic review and meta-analysis

(2014) Xuequn Ren et al.   Journal of Cancer Research and Therapeutics

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

Mitochondrial dysfunction-related genes in hepatocellular carcinoma

(2013) Shusen Zheng   Frontiers in Bioscience-Landmark

Anti-Tumor Effects of Mfn2 in Gastric Cancer

(2013) Ge-Er Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitofusin2 Mutations Disrupt Axonal Mitochondrial Positioning and Promote Axon Degeneration

(2012) A. L. Misko et al.   JOURNAL OF NEUROSCIENCE

Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells

(2012) Buntitabhon Sirichanchuen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Immuno-enhancement effects of Shenqi Fuzheng Injection on cyclophosphamide-induced immunosuppression in Balb/c mice

(2011) Jinxu Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mitofusin-2 is a novel direct target of p53

(2010) Weilin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shenqi fuzheng, an injection concocted from chinese medicinal herbs, combined with platinum-based chemotherapy for advanced non-small cell lung cancer: a systematic review

(2010) Ju Dong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma

(2010) Baiye Jin et al.   MEDICAL ONCOLOGY

Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells

(2010) Weilin Wang et al.   MEDICAL ONCOLOGY

Modulation of radiation-induced tumour necrosis factor-α and transforming growth factor β1 expression in the lung tissue by Shengqi Fuzheng injection

(2010) Liu   Molecular Medicine Reports

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1 /Mitofusin-2 Regulatory Pathway in Response to Physical Activity

(2009) M. I. Hernandez-Alvarez et al.   DIABETES CARE

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

(2009) Olga Martins de Brito et al.   MITOCHONDRION

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE