A Physiologically Based Pharmacokinetic Model for Optimally Profiling Lamotrigine Disposition and Drug–Drug Interactions

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex

(2018) Todd M. Conner et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters

(2016) Daniela Milosheska et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

(2015) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology

(2015) Akshanth R. Polepally et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Biopharmaceutic Risk Assessment of Brand and Generic Lamotrigine Tablets

(2015) Soundarya Vaithianathan et al.   MOLECULAR PHARMACEUTICS

Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective

(2014) Guo Yu et al.   AAPS Journal

Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability

(2014) Zhican Wang et al.   ENDOCRINOLOGY

Assessment and management of bipolar disorder: summary of updated NICE guidance

(2014) T. Kendall et al.   BMJ-British Medical Journal

Drug treatment of epilepsy in adults

(2014) D. Schmidt et al.   BMJ-British Medical Journal

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

(2013) Nikolaos Tsamandouras et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 2: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs and Drugs Used to Treat Non-Epilepsy Disorders

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

(2013) Tracy Glauser et al.   EPILEPSIA

Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients—nonlinear mixed effects modelling approach

(2013) Branka Brzaković et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Assessing Impact of Real-World Dosing Irregularities With Lamotrigine Extended-Release and Immediate-Release Formulations by Pharmacokinetic Simulation

(2013) Chao Chen et al.   THERAPEUTIC DRUG MONITORING

Bioequivalence of Lamotrigine 50-mg Tablets in Healthy Male Volunteers: a Randomized, Single-Dose, 2-Period, 2-Sequence Crossover Study

(2012) S. Perez-Lloret et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Methodologies used to identify and characterize interactions among antiepileptic drugs

(2012) Cecilie Johannessen Landmark et al.   Expert Review of Clinical Pharmacology

Lamotrigine and its N2-glucuronide during pregnancy: The significance of renal clearance and estradiol

(2011) Arne Reimers et al.   EPILEPSY RESEARCH

Lamotrigine and valproate pharmacokinetics interactions in epileptic patients

(2010) Mladena Lalic et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Mechanistic Approaches to Predicting Oral Drug Absorption

(2009) Weili Huang et al.   AAPS Journal

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects

(2009) L. Almeida et al.   ACTA NEUROLOGICA SCANDINAVICA

Computational Oral Absorption Simulation for Low-Solubility Compounds

(2009) Kiyohiko Sugano   CHEMISTRY & BIODIVERSITY

Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17 -Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy

(2009) H. Chen et al.   DRUG METABOLISM AND DISPOSITION

The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors

(2009) Peter I. Mackenzie et al.   DRUG METABOLISM REVIEWS

Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959-2009

(2009) Simon D. Shorvon   EPILEPSIA

Drug interactions involving the new second- and third-generation antiepileptic drugs

(2009) Cecilie Johannessen Landmark et al.   Expert Review of Neurotherapeutics

The Effect of Raltegravir on the Glucuronidation of Lamotrigine

(2009) Matthijs van Luin et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Variation in glucuronidation of lamotrigine in human liver microsomes

(2009) U. A. Argikar et al.   XENOBIOTICA

Induction Effects of Ritonavir: Implications for Drug Interactions

(2008) Michelle M Foisy et al.   ANNALS OF PHARMACOTHERAPY

The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe

(2008) DM Burger et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Bioequivalence of generic lamotrigine 100-mg tablets in healthy Thai male volunteers: A randomized, single-dose, two-period, two-sequence crossover study

(2008) Arunee Srichaiya et al.   CLINICAL THERAPEUTICS

Steady-state Pharmacokinetics of Lamotrigine when Converting from a Twice-daily Immediate-release to a Once-daily Extended-release Formulation in Subjects with Epilepsy (The COMPASS Study)

(2007) Debra J Tompson et al.   EPILEPSIA