Sodium Dichloroacetate Pharmacological Effect as Related to Na–K–2Cl Cotransporter Inhibition in Rats

Inflammatory role of high salt level in tumor microenvironment (Review)

(2017) Suneetha Amara et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

(2017) Evangelos D. Michelakis et al.   Science Translational Medicine

Inhibition of retinoic acid receptor β signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells

(2017) Cecilie Abildgaard et al.   Oncotarget

Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxel-resistant human lung cancer cells to paclitaxel

(2017) Hong Sun et al.   Oncotarget

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle

(2016) Jurate Stanevičiūtė et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro

(2016) Tatjana Harting et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism

(2016) Naoyuki Makita et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Synergistic Anticancer Potential of Dichloroacetate and Estradiol Analogue Exerting their Effect via ROS-JNK-Bcl-2-Mediated Signalling Pathways

(2015) Xiao Xing Stander et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ion Transporters in Brain Tumors

(2015) Damin Cong et al.   CURRENT MEDICINAL CHEMISTRY

Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells

(2015) Nelson Ho et al.   EXPERIMENTAL CELL RESEARCH

Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3

(2015) Chiara Agnoletto et al.   Oncotarget

Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition

(2014) Cecilie Abildgaard et al.   Journal of Translational Medicine

Sodium Is Not Required for Chloride Efflux via Chloride/Bicarbonate Exchanger from Rat Thymic Lymphocytes

(2014) Donatas Stakišaitis et al.   Biomed Research International

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

(2013) W Y Sanchez et al.   BRITISH JOURNAL OF CANCER

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

(2013) E. M. Dunbar et al.   INVESTIGATIONAL NEW DRUGS

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

(2012) G Sutendra et al.   ONCOGENE

Diuretics: a review

(2012) D. Wile   ANNALS OF CLINICAL BIOCHEMISTRY

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

(2011) E Babu et al.   ONCOGENE

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

(2010) B M Madhok et al.   BRITISH JOURNAL OF CANCER

Chloride Ion Modulates Cell Proliferation of Human Androgen-independent Prostatic Cancer Cell

(2010) Kenji Hiraoka et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Na-K-Cl Cotransporter-1 in the Mechanism of Ammonia-induced Astrocyte Swelling

(2008) Arumugam R. Jayakumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Long-term Treatment of Children With Congenital Lactic Acidosis With Dichloroacetate

(2008) P. W. Stacpoole et al.   PEDIATRICS