Article
Immunology
Yan Li, Wei Li, Li Huang, Huijia Li, Peipeng He, Chao Xue
Summary: This study investigated the association between microscopic polyangiitis and the single nucleotide polymorphism rs807185 in autophagy-associated gene 4A (ATG4A) in the Chinese population. Using multiplex polymerase chain reaction and high-throughput sequencing, it was found that the control group had a higher frequency of the A allele of rs807185 compared to the microscopic polyangiitis group, suggesting that the A allele of rs807185 may have a protective effect against microscopic polyangiitis in the Chinese population. However, the molecular mechanisms remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Chenxi Liu, Songxin Yan, Haizhen Chen, Ziyan Wu, Liubing Li, Linlin Cheng, Haolong Li, Yongzhe Li
Summary: This study found that the GTF2I rs117026326 and rs73366469 SNPs were strongly associated with SSc in the Chinese Han population, while NFKB1 rs1599961 showed a suggestive association with SSc. However, TYK2 rs2304256 was not significantly associated with SSc in this particular population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Liping Shen, Zhengyuan Wang, Jiajie Zang, Hong Liu, Ye Lu, Xin He, Chunfeng Wu, Jin Su, Zhenni Zhu
Summary: This study aimed to investigate the association between dietary iron intake, SNP of rs10830963 in MTNR1B gene, and glucose metabolism. The results showed that dietary iron intake was associated with elevated fasting glucose and higher HbA1c among G allele carriers of rs10830963, while no significant results were observed among G allele non-carriers.
Article
Biotechnology & Applied Microbiology
Yu Zhou, Jie Chen, Fenghua Bai, Rubing Mo, Haihong Wu, Lei Zhang, Jie Zhao, Linhui Huang, Qi Lin, Chanyi He, Linsang Lin, Siguang Li, Tian Xie, Yipeng Ding
Summary: This study investigated the relationship between IL23R variants and COPD susceptibility in the Chinese population. The results showed a significant association between rs7517847 and increased risk of COPD. Haplotype analysis indicated that the AAC and GGA haplotypes formed by rs2201841, rs12743974, and rs10889677 were associated with reduced risk of COPD.
JOURNAL OF GENE MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Liwen Fan, Lan Ma, Guirong Zhu, Siyue Yao, Xiaofeng Li, Xin Yu, Yongchu Pan, Lin Wang
Summary: Our GWAS study identified chromosome 2 variants, including rs147680216, as well as three novel susceptibility loci, associated with the risk of premolar agenesis in the Chinese population.
Article
Genetics & Heredity
Sihle E. Mabhida, Jyoti R. Sharma, Teke Apalata, Charity Masilela, Sibusiso Nomatshila, Lawrence Mabasa, Hannah Fokkens, Mongi Benjeddou, Babu Muhamed, Samukelisiwe Shabalala, Rabia Johnson
Summary: The study found a lack of association between MTHFR (rs1801133) and the risk of HTN in an indigenous South African population, but identified an interaction between rs1801133, age, and gender.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Yue Zhang, Changgui Kou, Lin Jia, Yangyang Gao, Xin Li, Hao Wu, Naifei Chen, Zheng Lv
Summary: This study found an association between the rs4784227 polymorphism of CASC16 and breast cancer susceptibility, as well as its correlation with clinical characteristics of breast cancer patients. However, there was no significant association between this polymorphism and breast cancer prognosis.
Article
Genetics & Heredity
Jiaqi Cui, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Ning Wang, Huan Chen, Yanqi Peng, Sijia Fei, Wang Ling, Chaoying Guo, Juanchuan Yao, Wei Cui
Summary: Evidence suggests a strong genetic basis for type 2 diabetes (T2D), with activated STAT4 playing an inflammatory role as an important mediator of diabetes-related inflammation. A study in the Chinese Han population found an association between STAT4 genetic polymorphisms and T2D susceptibility, particularly highlighting the significance of rs3821236 in overall and subgroup T2D risk analyses. The findings may contribute new insights for personalized diagnosis/protection against T2D.
BMC MEDICAL GENOMICS
(2021)
Article
Medical Laboratory Technology
Min Jin, Fengke Lu, Xi Li, Wei Zhou, Sihui Li, Yanting Jiang, Huiling Wu, Jian Wang
Summary: This study found that the rs9266 gene polymorphism and TAT haplotype in the KRAS gene may be associated with an increased risk of breast cancer in Chinese women, while the GAC haplotype may be a protective factor against breast cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Ophthalmology
Shiya Cai, Jun Zhang, Chunya Zhou, Wenjian Shi, Yingying Gao, Rui Chang, Handan Tan, Qingfeng Wang, Xingsheng Ye, Qingfeng Cao, Qingyun Zhou, Peizeng Yang, Jianmin Hu
Summary: This study suggests that CDK6 gene variants rs2282983 and rs42034 may be associated with genetic susceptibility to BD and significantly correlated with skin lesions in BD patients.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Immunology
Juan Zhang, Ming-gui Wang, Jian-Qing He
Summary: This study reveals the association between ALOX5 gene polymorphism and susceptibility to multisystemic tuberculosis in the Chinese Han population.
MICROBIAL PATHOGENESIS
(2023)
Article
Critical Care Medicine
Athenais Boucly, Laurent Savale, Xavier Jais, Fabrice Bauer, Emmanuel Bergot, Laurent Bertoletti, Antoine Beurnier, Arnaud Bourdin, Helene Bouvaist, Sophie Bulifon, Celine Chabanne, Ari Chaouat, Vincent Cottin, Claire Dauphin, Bruno Degano, Pascal De Groote, Nicolas Favrolt, Yuanchao Feng, Delphine Horeau-Langlard, Mitja Jevnikar, Etienne-Marie Jutant, Zhiying Liang, Pascal Magro, Pierre Mauran, Pamela Moceri, Jean-Francois Mornex, Sylvain Palat, Florence Parent, Francois Picard, Jeremie Pichon, Patrice Poubeau, Gregoire Prevot, Sebastien Renard, Martine Reynaud-Gaubert, Marianne Riou, Pascal Roblot, Olivier Sanchez, Andrei Seferian, Cecile Tromeur, Jason Weatherald, Gerald Simonneau, David Montani, Marc Humbert, Olivier Sitbon
Summary: The study findings suggest that initial triple combination therapy containing parenteral prostacyclin is associated with a higher survival rate in patients with PAH, particularly in younger high-risk patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Jia-lin Teng, Xia Chen, Jianhua Chen, Ting Zeng, Lin He, Meihang Li, Cai-nan Luo, Shuang Liu, Ting-ting Ding, Kuerbanjiang Yimaiti, Xingwang Li, Yonghe Ding, Xiao-bing Cheng, Juan Zhou, Jun-na Ye, Jue Ji, Yu-tong Su, Hui Shi, Yue Sun, Chengwen Gao, Qiong-yi Hu, Hui-hui Chi, Xuan Yuan, Zhuo-chao Zhou, Dong Wang, Ke Wang, Dong Feng, Changgui Li, Yuanchao Sun, Yujuan Niu, Xiaolei Xu, Lin-jie Chen, Jian Xu, Li-jun Wu, Zhaowei Zhou, Dun Pan, Haitao Niu, Cheng-de Yang, Yongyong Shi, Zhiqiang Li, Hong-lei Liu
Summary: In this study, independent amino acid polymorphisms in HLA molecules associated with Han Chinese patients with AOSD were identified by fine mapping the MHC locus. Specific positions in HLA-DQ alpha 1 and HLA-DR beta 1 were determined as major determinants for AOSD, along with associations with three main HLA class II alleles. This study reveals the role of functional variations in the class II HLA region in the pathogenesis of AOSD.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Endocrinology & Metabolism
Yang Sun, Ye Lv, Hui-Wen Ren, Guan-Yu Wang, Li-Na Xuan, Yi-Yang Luo, Zhi-Lin Luan
Summary: The study found a significant association between MAP3K4 and schizophrenia in the Northeast Chinese Han population, with certain SNPs showing strong correlation with the disease.
METABOLIC BRAIN DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Min Gao, Yongwen Li, Hua Huang, Yaguang Fan, Ruifeng Shi, Lianchun Su, Chen Chen, Xuanguang Li, Guangsheng Zhu, Di Wu, Peijun Cao, Hongyu Liu, Jun Chen, Shirong Kang
Summary: This study demonstrates that genetic variants in PRC2 genes, including rs17171119T>G, rs10898459 T>C, and rs1136258 C>T, are associated with a decreased risk of developing lung cancer.
ONCOTARGETS AND THERAPY
(2023)
