Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Lipid sensing by mTOR complexes viade novosynthesis of phosphatidic acid

(2017) Deepak Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute metabolic amplification of insulin secretion in mouse islets: Role of cytosolic acetyl-CoA

(2016) Uwe Panten et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

(2016) Gemma L. Pearson et al.   Molecular Metabolism

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion

(2016) Mahmoud El Azzouny et al.   Molecular Metabolism

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

(2015) James Cantley et al.   BMC BIOLOGY

LKB1 couples glucose metabolism to insulin secretion in mice

(2015) Accalia Fu et al.   DIABETOLOGIA

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

(2014) Sungki Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins

(2014) Yipeng Du et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

(2014) Jenny D.Y. Chow et al.   Molecular Metabolism

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo

(2010) J. Cantley et al.   DIABETOLOGIA

Quantification of Insulin Gene Expression During Development of Pancreatic Islet Cells

(2010) Fang-Xu Jiang et al.   PANCREAS

Critical roles for the TSC-mTOR pathway in β-cell function

(2009) Hiroyuki Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of PKC  Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse  -Cells

(2009) J. Cantley et al.   DIABETES

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism

(2008) Sarah M. Ronnebaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice

(2008) James Cantley et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells

(2007) Michael J. MacDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS