Article
Biology
Pierre Jacquet, Angelique Stephanou
Summary: Using the right terminology is crucial in accurately describing biological phenomena, as inappropriate use may lead to biases in understanding, which can have negative consequences. This article focuses on the term "reprogramming" associated with cancer cell metabolism, highlighting inconsistencies in its usage and criticizing the overemphasis on the role of mutations in metabolic adaptation. With the growing interest in metabolism and the Warburg effect in cancer research, it is important to discuss these terms and concepts in detail.
Review
Biochemistry & Molecular Biology
Laura A. Wengert, Sarah J. Backe, Dimitra Bourboulia, Mehdi Mollapour, Mark R. Woodford
Summary: Mitochondrial function relies on molecular chaperones, including heat shock proteins (Hsps) such as Hsp90 and its chaperone TNF-receptor-associated protein-1 (TRAP1). TRAP1, primarily localized in mitochondria, plays a crucial role in cellular metabolic reprogramming and mitochondrial apoptosis. Upregulation of TRAP1 promotes the growth of cancer cells by enhancing glycolytic metabolism and inhibiting mitochondrial permeability transition, while attenuation of TRAP1 induces apoptosis in cancer cells. Furthermore, TRAP1 is subject to post-translational modifications that regulate its function and downstream effectors.
Review
Biochemistry & Molecular Biology
Katerina Honigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik
Summary: Metabolic plasticity is an important characteristic of cancer cells in tumorigenesis, allowing them to reshape metabolic pathways to support increased energy demands. The selective pressures in the tumor microenvironment force cancer cells to adapt by reorganizing their metabolism. Understanding metabolic reprogramming is crucial for developing targeted therapies for cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Oncology
Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W. Ashton, David Joyce, Xuanmao Jiao, Richard G. Pestell
Summary: Recent studies have shown that metabolic heterogeneity occurs at various levels within tumors, impacting tumor progression and response to treatment. Understanding the complex interactions between metabolic properties, oncogenes, and the tumor microenvironment is crucial for developing more effective personalized treatments for cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Gerardo M. Nava, Luis Alberto Madrigal-Perez
Summary: This review discusses the metabolic signature of the Warburg effect and related phenotypes, and proposes some potential cancer biomarkers associated with the Warburg effect.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Review
Oncology
Rishabh Kumar, Anurag Mishra, Priyanka Gautam, Zainab Feroz, Sivakumar Vijayaraghavalu, Eviania M. Likos, Girish C. Shukla, Munish Kumar
Summary: Deregulated cellular metabolism is a key feature of cancer, with cancer cells undergoing abnormal metabolic reprogramming to meet high energy demands. This review focuses on the mechanisms of major metabolic pathways and enzymes that are altered in cancer, highlighting the therapeutic potential of targeting clinically relevant metabolic intermediates. Cancer cells adapt their metabolism to survive and proliferate under nutrient-deficient conditions, and this adaptation is influenced by the physiological demands of the cancer cell and the surrounding tissue. Additionally, numerous metabolic regulators play a role in cancer cell proliferation. Understanding metabolic reprogramming in tumors and utilizing cancer metabolomics could lead to new strategies for cancer therapeutics.
Review
Oncology
Assunta Sellitto, Giovanni Pecoraro, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Pasquale Saggese, Cesar A. Martinez, Claudio Scafoglio, Roberta Tarallo
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in the metabolic reprogramming of cancer, forming a complex network of interactions. They are considered promising diagnostic and prognostic biomarkers, providing a novel approach for personalized therapy.
Article
Cell Biology
Andrew Blum, Kate Mostow, Kailey Jackett, Estelle Kelty, Tenzing Dakpa, Carly Ryan, Engda Hagos
Summary: The study indicates that KLF4 plays a role in regulating cell metabolism and promoting energy production, which may be beneficial for cancer treatment.
Review
Oncology
Seyedeh Sahar Mortazavi Farsani, Vivek Verma
Summary: New research reveals that not only cancer cells but also other cell types, including immune cells, exhibit the Warburg effect, converting glucose to lactate even in the presence of sufficient oxygen. Lactate plays a crucial role in metabolism and cell signaling, but high levels can inhibit immune cell function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Jack C. M. Ng, C. Mary Schooling
Summary: In this study, genetically predicted higher basal metabolic rate was found to be associated with an increase in cancer risk, with similar effects observed for both men and women, and consistent results after adjustment for insulin-like growth factor 1. This suggests that basal metabolic rate may be a potential modifiable target for cancer prevention that warrants further investigation.
FRONTIERS IN GENETICS
(2021)
Review
Agriculture, Multidisciplinary
Asifa Khan, Shumaila Siddiqui, Syed Akhtar Husain, Sybille Mazurek, Mohammad Askandar Iqbal
Summary: The article discusses the differences in metabolism between cancer cells and normal cells, as well as the role of plant-based compounds in modulating cancer metabolism. It proposes a therapeutic strategy of targeting metabolic vulnerabilities of cancer using plant-based compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Merve Kulbay, Bruno Johnson, Guillaume Ricaud, Marie-Noelle Seguin-Grignon, Jacques Bernier
Summary: This study reveals that DFF40 may regulate cell metabolism and mitochondrial integrity during cell death. DFF40-deficient cells exhibit increased resistance to apoptosis and display the Warburg effect phenotype. Additionally, DFF40 can translocate to the mitochondria following apoptosis induction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Christian Marx, Juergen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Bluemel, Mandy Beyer, Doerte Hoelzer, Rene Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel, Oliver H. Kraemer
Summary: Chemotherapeutics that cause DNA replication stress increase the metabolism of colorectal cancer (CRC) cells, and glucose restriction might improve the effectiveness of classical chemotherapy against p53-positive cells.
CANCER & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Pierre Jacquet, Angelique Stephanou
Summary: This review explores the evolving understanding of tumor cell metabolism, particularly glycolytic and oxidative metabolism, tracing its evolution from the pioneering work of Otto Warburg. Misinterpretations of Warburg's work have hindered the understanding of tumor cell metabolism, leading to new concepts like metabolic switch and metabolic reprogramming. The metabolic signature of cancer is complex and cannot be simplified to a single factor, but is expressed at the tissue level through cells' ability to dynamically explore a vast metabolic landscape in heterogeneous environments.
Article
Biochemistry & Molecular Biology
Yufeng Guo, Liqiu Su, Qi Liu, Yan Zhu, Zongjie Dai, Qinhong Wang
Summary: Yarrowia lipolytica is a versatile chassis cell used in biotechnological applications, and this study developed a high-quality genome-scale metabolic model for this cell, providing insights into its metabolic mechanism and guiding metabolic engineering.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biology
Maximilian Fichtner, Stefan Schuster, Heiko Stark
Article
Engineering, Biomedical
Julian Sartori, Heiko Stark
Summary: This study analyzed the 3D fiber tracks in macroscopic tendon samples, revealing that the insertion is not reinforced in terms of fiber numbers or sizes. The orientation of fibers in the tendon center is higher than in the margins, which could inspire material development. Fibers inserting at a protrusion of the insertion area stem from a distinct portion within the tendon, suggesting that fibrous structure analysis can link macro- to micromechanics.
ACTA BIOMATERIALIA
(2021)
Article
Genetics & Heredity
Philipp Dirksen, Adrien Assie, Johannes Zimmermann, Fan Zhang, Adina-Malin Tietje, Sarah Arnaud Marsh, Marie-Anne Felix, Michael Shapira, Christoph Kaleta, Hinrich Schulenburg, Buck S. Samuel
G3-GENES GENOMES GENETICS
(2020)
Review
Cell Biology
Emanuel Barth, Patricia Sieber, Heiko Stark, Stefan Schuster
Article
Multidisciplinary Sciences
Georgios Marinos, Christoph Kaleta, Silvio Waschina
Article
Multidisciplinary Sciences
Michal Sitina, Heiko Stark, Stefan Schuster
Summary: The optimal hematocrit value has been achieved through evolution in humans and higher animals, balancing sufficiently high erythrocyte concentrations with sufficiently low blood viscosity. According to a novel calculation, the optimal HCT value under constant cardiac power ranges from 0.5 to 0.7, consistent with observed values in natural blood dopers at exertion.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Maximilian Fichtner, Stefan Schuster, Heiko Stark
Summary: Research on aging focuses on the deterioration of physiological features, with a particular emphasis on the molecular level. The susceptibility of proteinogenic amino acids to non-enzymatic modification plays a crucial role in protein damage and function. Analyzing the distribution of amino acids between the protein shell and core can provide valuable insights for various applications such as phylogeny and molecular medicine.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Heiko Stark, Martin S. Fischer, Alexander Hunt, Fletcher Young, Roger Quinn, Emanuel Andrada
Summary: Studying canine locomotion is intriguing due to the wide range of body sizes and physiques among different breeds. Creating detailed musculoskeletal models can help bridge the knowledge gap in current research. By comparing predicted activation patterns from the model with experimental data, the analysis of how body size, physique, agility, and disease influence neuronal control and joint loading in dog locomotion can be accelerated.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samir Giri, Leonardo Ona, Silvio Waschina, Shraddha Shitut, Ghada Yousif, Christoph Kaleta, Christian Kost
Summary: The study reveals that metabolic dissimilarity between bacterial genotypes is a key factor determining the establishment of metabolic cross-feeding interactions in microbial communities. Results showed that a greater phylogenetic distance and metabolic network dissimilarity between donor and recipient were associated with better growth of auxotrophic recipients, indicating that interacting with metabolically dissimilar partners benefits recipient genotypes.
Article
Cell Biology
Marie-Luise Ederer, Madlen Guenther, Lena Best, Julia Lindner, Christoph Kaleta, Otto W. Witte, Rowena Simon, Christiane Frahm
Summary: Inflammation is believed to play a role in cognitive decline during aging. This study examines the impact of physical activity and social isolation on cognitive function and inflammation in old mice. The results show that voluntary wheel running improves cognitive function, while social isolation has negative effects. Inflammatory markers increase in both the hippocampus and colon during aging, and voluntary wheel running specifically attenuates intestinal inflammation.
Review
Biochemistry & Molecular Biology
Lady Johanna Forero-Rodriguez, Jonathan Josephs-Spaulding, Stefano Flor, Andres Pinzon, Christoph Kaleta
Summary: Parkinson's Disease is a neurodegenerative disease associated with dysbiosis and exposure to heavy metals, affecting the gut-brain axis. Integrative modeling and modulation of gut microbiota may provide potential treatment options for neurodegeneration.
Article
Cell Biology
Silvio Schmidt, Madlen Haase, Lena Best, Marco Groth, Julia Lindner, Otto W. Witte, Christoph Kaleta, Christiane Frahm
Summary: Research has shown that late-onset environmental enrichment (EE) can improve cognitive abilities and affect gene expression in the hippocampus of old mice. The positive cognitive effects were reflected by specific changes in the hippocampal transcriptome, with late-onset EE having a greater impact on transcription than age. Some genes that play a role in dendritic spine plasticity and age-related molecular signaling cascades were counter-regulated by late-onset EE. These findings suggest that EE is a promising non-pharmacological intervention against cognitive decline.
Review
Biochemistry & Molecular Biology
Helena U. Zacharias, Christoph Kaleta, Francois Cossais, Eva Schaeffer, Henry Berndt, Lena Best, Thomas Dost, Svea Gluesing, Mathieu Groussin, Mathilde Poyet, Sebastian Heinzel, Corinna Bang, Leonard Siebert, Tobias Demetrowitsch, Frank Leypoldt, Rainer Adelung, Thorsten Bartsch, Anja Bosy-Westphal, Karin Schwarz, Daniela Berg
Summary: This article summarizes the research progress on the impact of the gut-brain axis on neurodegenerative diseases. Studies on the microbiome and metabolome have provided important insights into disease mechanisms and offered new avenues for prevention and treatment of PD and AD.
Proceedings Paper
Cell & Tissue Engineering
Heiko Stark, Martin S. Fischer, Emanuel Andrada
Summary: Based on existing musculoskeletal models of the dog, two additional models for extreme body sizes of the Dachshund and Great Dane have been developed, with future plans to include models for the French Bulldog, Whippet, and Malinois breeds. These models are expected to advance the analysis of the impact of body size, physique, and mobility on locomotion and joint dynamics in dogs.
BIOMIMETIC AND BIOHYBRID SYSTEMS, LIVING MACHINES 2022
(2022)
Article
Biology
Julian Katzke, Pavel Puchenkov, Heiko Stark, Evan P. Economo
Summary: Understanding muscle performance through muscle architecture analysis is crucial for ecology and evolution studies. Tomographic techniques provide an alternative to tedious dissections for measuring muscle architecture features. Utilizing Blender Python API scripts for image analysis enables fast and accurate estimation of animal muscle architecture.
INTEGRATIVE ORGANISMAL BIOLOGY
(2022)