Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Pan Shen, Xuan Deng, Zhe Chen, Xin Ba, Kai Qin, Ying Huang, Yao Huang, Tingting Li, Jiahui Yan, Shenghao Tu
Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sha-Sha Tao, Fan Cao, Napoleon Bellua Sam, Hong-Miao Li, Ya-Ting Feng, Jing Ni, Peng Wang, Xiao-Mei Li, Hai-Feng Pan
Summary: DKK-1 is known for inhibiting classic Wnt signaling pathways in bone formation and metastasis, but recent studies have shown its roles in bone resorption, immune homeostasis, inflammation, and autoimmune diseases. Research suggests DKK-1 could be a biomarker for autoimmune diseases and a potential treatment target.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zexi Jia, Mengtian Guo, Xintong Ge, Fanglian Chen, Ping Lei
Summary: IL-33 is a cytokine that is passively produced in response to tissue damage or cell necrosis. It interacts with the ST2 receptor to produce pro-inflammatory cytokines and plays a crucial role in immune regulation and neurodegenerative diseases.
Review
Cell Biology
Maria Galindo-Izquierdo, Jose Luis Pablos Alvarez
Summary: The complement system, consisting of more than 50 proteins, plays a key role in recognizing and protecting against foreign or damaged molecular components. Pathological activation of the complement system is involved in the pathogenesis of autoimmune diseases, and it may serve as a potential therapeutic target in rheumatologic autoimmune processes.
Review
Immunology
Zhen-yu Li, Ming-Long Cai, Yi Qin, Zhu Chen
Summary: Age/autoimmunity-associated B cells (ABCs) are a unique B cell subpopulation with distinct transcriptional and cell surface characteristics. They rely on TLR7 or TLR9 and T cell-derived cytokines for differentiation and their aberrant expansion is associated with systemic autoimmune diseases. Recent studies have shown a pathogenic role of increased ABCs in rheumatoid arthritis (RA), suggesting that targeting specific B cell subsets could be a promising treatment strategy for inflammatory arthritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Shihan Xu, Tingwei Zhang, Zhengguo Cao, Wenjie Zhong, Chuangwei Zhang, Han Li, Jinlin Song
Summary: Integrin-alpha 9 beta 1 is a crucial cell membrane receptor with complex signaling pathways. It plays important roles in regulating cell physiological states and is involved in various diseases such as cancer, autoimmune diseases, nerve injury, and thrombosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Nicolas Charles, Inge Kortekaas-Krohn, Emek Kocaturk, Joerg Scheffel, Sabine Altrichter, Carolin Steinert, Yi-Kui Xiang, Jan Gutermuth, Laurent L. Reber, Marcus Maurer
Summary: Autoimmunity is characterized by a loss of tolerance to self-antigens, resulting in the production of pathogenic autoreactive antibodies (AAb). While AAb are commonly found in the general population without clinical symptoms, they can cause antibody-mediated autoimmune diseases (AbAID) in certain individuals. Recent studies have identified a role for IgE antibodies in AbAID, suggesting their potential as therapeutic targets.
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Dongfu Jin, Yaxin Jiang, Lu Chang, Jing Wei, Jian Sun
Summary: Interleukin-2 (IL-2) is an immunomodulatory cytokine with limited clinical use due to its short half-life and toxicity. The development of cell-type-selective engineered IL-2 products aims to enhance its efficacy and reduce side effects. This review summarizes the characteristics of reported IL-2 mutants and discusses their design principles and potential applications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kripa Jain, Kalyani Barve, Lokesh Kumar Bhatt
Summary: This review summarizes the physiological roles and signal transduction of gasdermins and highlights their significance in pathological conditions such as autoimmune diseases, kidney diseases, and central nervous system diseases.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Alba Sanchez-Fernandez, Stephanie Zandee, Jesus Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Ruben Lopez-Vales
Summary: This study demonstrates that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1-R8. Administration of recombinant human IL-37 exerts therapeutic actions in EAE mice, but IL-37 transcripts are not up-regulated in peripheral blood mononuclear cells and brain lesions of MS patients.
Review
Biochemistry & Molecular Biology
Jame Frenay, Pierre-Simon Bellaye, Alexandra Oudot, Alex Helbling, Camille Petitot, Christophe Ferrand, Bertrand Collin, Alexandre M. M. Dias
Summary: Cancer is a leading cause of death worldwide, and inflammation is recognized as a hallmark of carcinogenesis. IL-1RAP has shown great potential as a new target for cancer therapy. This review provides an overview of IL-1RAP's structure, genetics, and role in tumor development, as well as a focus on IL-1RAP-targeted therapies currently under preclinical or clinical development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yue Wu, Ziwei Dai, Haili Wang, Hong Wang, Lingling Wu, Huayun Ling, Ying Zhu, Dongqing Ye, Bin Wang
Summary: This study systematically evaluated the diagnostic value of 14-3-3 eta protein for RA, and found that it is a supplementary biomarker for the diagnosis of RA.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Rheumatology
Yan-Mei Mao, Tao Liao, Qian-Ling Ye, Guo-Cui Wu, Qin Zhang, Sha-Sha Tao, Chan-Na Zhao, Qian Wu, Yi-Lin Dan, Hai-Feng Pan, Dong-Qing Ye
Summary: This study evaluated the circulating level of sclerostin in rheumatoid arthritis (RA) patients and summarized its role. The meta-analysis showed that RA patients had higher circulating sclerostin levels compared to normal controls. Subgroup analyses indicated that age, region, and assay method were associated with sclerostin level in RA patients.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Review
Immunology
Yue Chen, Zhiwei Xu, Peng Wang, Xiao-Mei Li, Zong-Wen Shuai, Dong-Qing Ye, Hai-Feng Pan
Summary: Autoimmune manifestations have been reported in response to certain COVID-19 vaccines, but it is still unclear whether there is a causal relationship. These reports can help guide the clinical assessment and management of autoimmune manifestations after vaccination.
Article
Nursing
Chunxia Ren, Decun Zhou, Yinguang Fan, Baozhu Li, Wanfei Zhang, Yun Shen, Shihui Yu, Li Jiang, Fengqiong Yu, Yongli Duan, Deqing Peng, Xuehong Cheng, Le Wu, Changhao Wu, Dongqing Ye
Summary: The study found that anxiety and depression symptoms are prevalent among surgical nurses in Anhui province during the COVID-19 epidemic, and low levels of social support are significant influencing factors. Targeted psychological interventions are recommended to be implemented immediately to promote the mental health of surgical nurses.
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: By combining genome-wide association studies and transcriptome-wide association studies, we identified candidate genes associated with systemic lupus erythematosus and discovered a strong association between the CD83 gene and SLE. We also identified 276 gene candidates at the 110 SLE loci and demonstrated a regulatory effect of a putative causal variant on the ACAP1 gene.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Virology
Akililu Alemu Ashuro, Si-Chen Zhang, Ting Wang, Qin-Shu Chu, Yuan-Sheng Fu, Yin-Guang Fan, Dong-Qing Ye
Summary: This study summarizes the impact of PIs/r-based ART on serum/plasma IL-6 levels in HIV-infected individuals. It was found that IL-6 levels increased after combination therapy. This result highlights the need to monitor IL-6 levels for effective treatment of systemic inflammation and related disorders.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Rheumatology
Xu-Fan Wang, Wen-Jing Xu, Fei-Fei Wang, Rui Leng, Xiao-Ke Yang, Hua-Zhi Ling, Yin-Guang Fan, Jin-Hui Tao, Zong-Wen Shuai, Li Zhang, Dong-Qing Ye, Rui-Xue Leng
Summary: In contrast to previous observational studies, this study found that longer leukocyte telomere length is significantly associated with increased risk of SLE.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Nutrition & Dietetics
Xin-yu Fang, Liang-wei Qi, Hai-feng Chen, Peng Gao, Qin Zhang, Rui-xue Leng, Yin-guang Fan, Bao-zhu Li, Hai-feng Pan, Dong-qing Ye
Summary: This article provides a review of the roles of fructose intake and gut microbiota in regulating purine metabolism and explores the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. It also summarizes fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Bo Liu, Xin-Yu Fang, Yu-Lu Yan, Jun Wu, Xiao-Jie Lv, Jie Zhang, Liang-Wei Qi, Ting-Ting Qian, Yu-Yu Cai, Yin-Guang Fan, Dong-Qing Ye
Summary: There is an association between ambient temperature and outpatient visits for warts, where both low and high temperatures increase the risk while a large temperature drop is protective. Males and younger individuals are more sensitive to temperature, while the elderly are more susceptible to temperature changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Yu Xue, Ying Zhou, Tingrui Wang, Huijuan Chen, Lingling Wu, Huayun Ling, Hong Wang, Lijuan Qiu, Dongqing Ye, Bin Wang
Summary: AI-assisted diagnostic techniques show good diagnostic efficacy for thyroid nodules, especially for diagnosing patients under the age of 50.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Microbiology
Bao-Zhu Li, Hua Wang, Xian-Bao Li, Qian-Ru Zhang, Rong-Gui Huang, Hong Wu, Yi-Yu Wang, Kai-Di Li, Xiu-Jie Chu, Nv-Wei Cao, Hao-Yue Zhou, Xin-Yu Fang, Rui-Xue Leng, Yin-Guang Fan, Jin-Hui Tao, Zong-Wen Shuai, Dong-Qing Ye
Summary: This study presents a pilot analysis of fungal microbiota in patients with systemic lupus erythematosus (SLE), showing significant differences in diversity and composition compared to other diseases and healthy controls. The composition of fungal and bacterial microbiota is imbalanced in SLE patients, and there is a complex relationship network between them.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ting Wang, Yuanrui Xia, Xinhong Zhang, Nini Qiao, Susu Ke, Quan Fang, Dongqing Ye, Yinguang Fan
Summary: This study found that short-term exposure to air pollutants was associated with psoriasis outpatients. It is recommended for patients and high-risk individuals to reduce outdoor activities and improve skin protection measures when the air quality is poor.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Jie Zhang, Xin-Yu Fang, Jun Wu, Yin-Guang Fan, Rui-Xue Leng, Bo Liu, Xiao-Jie Lv, Yu-Lu Yan, Chen Mao, Dong-Qing Ye
Summary: This study investigated the associations between various air pollutants and the risk of incident rheumatoid arthritis (RA) and further estimated the impact of combined exposure to ambient air pollutants on the risk of developing RA under the modification effect of genetic predisposition.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Computer Science, Artificial Intelligence
Yongrui Chen, Huiying Li, Guilin Qi, Tianxing Wu, Tenggou Wang
Summary: Query graph construction aims to generate a correct SPARQL query to answer natural language questions on a knowledge graph. Existing methods face challenges in handling complex questions including complicated SPARQL syntax, huge search space, and locally ambiguous query graphs. This paper proposes a novel end-to-end approach that leverages a unified graph grammar called AQG and hierarchical autoregressive decoding to construct query graphs effectively. Experimental results demonstrate that the proposed method significantly improves the state-of-the-art performance on complex KGQA benchmarks.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Allergy
Hong Wang, Tingrui Wang, Haili Wang, Yue Wu, Lingling Wu, Huayun Ling, Dong-Qing Ye, Bin Wang
Summary: This meta-analysis suggests that C1q rs631090 may be associated with the risk of SLE, while rs172378 and rs292001 may not be associated. However, larger-scale studies are needed to confirm these findings due to the limited sample size.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2022)
