Article
Cell Biology
Tova M. Bergsten, Sarah E. Levy, Katherine E. Zink, Hannah J. Lusk, Melissa R. Pergande, Stephanie M. Cologna, Joanna E. Burdette, Laura M. Sanchez
Summary: This study discovered that a secreted protein called SPARC, produced by tumorigenic fallopian tube epithelial cells, enhances the release of norepinephrine (NE) from the ovary, influencing the primary metastasis of high grade serous ovarian cancer (HGSOC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Guyu Qin, Eun-Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo-Cheng Yuan, Zhe Li
Summary: Epithelial ovarian cancer (EOC) can originate from either fallopian tube epithelial (FTE) or ovarian surface epithelial (OSE) cells, but they exhibit different latencies and disease outcomes. Single cell RNA-sequencing revealed that FTE secretory stem/progenitor cells resemble mammary luminal progenitors, while OSE cells resemble basal cells. Additionally, an FT stromal subpopulation may serve as a niche for FTE cells, while Lgr5(+) OSE cells may self-sustain as their own niche. The differences in intrinsic expression programs and niche organizations of FTE and OSE cells may contribute to the development of EOCs.
Article
Cell Biology
Maxence Wisztorski, Soulaimane Aboulouard, Lucas Roussel, Marie Duhamel, Philippe Saudemont, Tristan Cardon, Fabrice Narducci, Yves-Marie Robin, Anne-Sophie Lemaire, Delphine Bertin, Nawale Hajjaji, Firas Kobeissy, Eric Leblanc, Isabelle Fournier, Michel Salzet
Summary: This study conducted an in-depth proteomic analysis of pre-neoplastic epithelial lesions in ovarian cancer using mass spectrometry imaging and immunohistochemistry techniques. Specific lesion markers were identified, and a lipidomic analysis confirmed the presence of specific lipid signatures in these lesions. The study provides new insights into the molecular mechanisms underlying the progression of ovarian cancer and confirms the fimbria origin of high-grade serous carcinoma.
CELL DEATH & DISEASE
(2023)
Article
Endocrinology & Metabolism
Laura J. Mauro, Megan Seibel, Caroline H. Diep, Angela Spartz, Carlos Perez Kerkvliet, Hari Singhal, Elizabeth M. Swisher, Lauren E. Schwartz, Ronny Drapkin, Siddharth Saini, Fatmata Sesay, Larisa Litovchick, Carol A. Lange
Summary: The study reveals that activated PRs support quiescence and pro-survival/pro-dissemination cell behaviors, potentially contributing to early HGSC progression. The results suggest that progesterone may not always confer protection against OC, with potential clinical opportunities to prevent HGSC development by targeting PRs, DREAM, and DYRKs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura, Ryoji Yao, Tetsuo Noda, Makiko Itami, Yoshitaka Hippo
Summary: Genetically engineered organoids have been shown to develop tumors in immunocompromised mice, providing new insights into the interactions among genotype, cell type, and tumor phenotype in tumorigenesis.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maobi Zhu, Na Wang, Sha Wang, Yao Wang, Xiawen Yang, Jianglin Fan, Yajie Chen
Summary: This study examined the injury and repair mechanism of the fallopian tube, the original site of high-grade serous ovarian carcinoma. The results showed that follicular fluid stimulation promotes cell differentiation and organoid formation, but also causes cell injury and apoptosis at high concentrations. These findings contribute to the investigation of the initiation mechanisms of high-grade serous ovarian carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hyeong In Ha, Eun Young Park, Kyung Jin Eoh, Yeon Jee Lee, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim
Summary: This study investigated the clinical significance of the ovarian cancer cluster region (OCCR) in BRCA1 and BRCA2 genes. The results showed that patients with BRCA1 pathogenic variants (PVs) in the OCCR region had shorter progression-free survival (PFS) compared to those outside the OCCR. This trend was more pronounced in the platinum-sensitive subgroup. However, no significant differences were found in overall survival (OS) between patients with BRCA1/2 PVs, regardless of the variant location.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Anne Kathrin Hoehn, Sabine Klagges, Albrecht Glaeser, Sabine Taubenheim, Nadja Dornhoefer, Jens Einenkel, Grit Gesine Ruth Hiller, Christine E. Brambs, Lars-Christian Horn
Summary: For non-uterine pelvic cancers, there is an increase in tumors originating from the fallopian tubes and a decrease in tumors originating from the ovaries. This trend is likely due to the reclassification of tumors previously classified as ovarian and a greater emphasis on examining resection specimens of non-uterine pelvic cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Naoko Nomoto, Shinichi Tate, Makoto Arai, Shinji Iizaka, Chisato Mori, Kenichi Sakurai
Summary: This study investigates the relationship between nutritional status before chemotherapy and chemotherapy discontinuation. The study finds that C-reactive protein-to-albumin ratio (CAR) can effectively predict the risk of chemotherapy interruption.
Review
Biochemistry & Molecular Biology
Isao Otsuka
Summary: High-grade serous carcinomas of the ovaries are a heterogeneous group of diseases with multifactorial etiology, potentially linked to inflammation from ovulation and genetic mutations like TP53. Other key genetic alterations include homologous recombination deficiency and CCNE1 amplification, which may be mutually exclusive. Intratumor heterogeneity from genomic instability can be observed early in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Phyllis van der Ploeg, Aniek Uittenboogaard, Steven L. Bosch, Paul J. van Diest, Yvonne J. W. Wesseling-Rozendaal, Anja van de Stolpe, Sandrina Lambrechts, Ruud L. M. Bekkers, Jurgen M. J. Piek
Summary: This study investigated the activity of key signal transduction pathways in serous tubal intraepithelial carcinoma (STIC) and high-grade serous carcinoma (HGSC) and compared them to normal Fallopian tube epithelium (FTE). The results showed that the ER pathway activity was lower, while the PI3K and HH pathway activity was higher in STIC and HGSC compared to FTE. This suggests that these pathways may play a crucial role in the neoplastic transformation of FTE into STIC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
John B. Liao, William R. Gwin, Renata R. Urban, Katie M. Hitchcock-Bernhardt, Andrew L. Coveler, Doreen M. Higgins, Jennifer S. Childs, Hania N. Shakalia, Ron E. Swensen, Sasha E. Stanton, Anna Tinker, Tanya A. Wahl, Richard G. Ancheta, Kathryn F. McGonigle, James Y. Dai, Mary L. Disis, Barbara A. Goff
Summary: The study evaluated the activity and safety of pembrolizumab with carboplatin in recurrent platinum-resistant ovarian cancer, showing that this treatment approach had modest activity and good tolerability. A ratio of peripheral T-cell exhaustion to radiographic tumor burden may help identify patients who are more likely to benefit from this chemoimmunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Medicine, General & Internal
Dan L. Longo, Rachel C. Sisodia, Marcela G. del Carmen
Summary: Lesions of the ovary and fallopian tube can be acute or chronic, and it is important to distinguish between benign and malignant causes. Referral to a gynecologic oncologist is often necessary for diagnostic assessment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi
Summary: The Japan Society of Gynecologic Oncology published the fifth edition of guidelines for ovarian cancer, fallopian tube cancer, and primary peritoneal cancer treatment in 2020. The guidelines include 6 chapters and 5 algorithms, with major changes such as revised title, broader involvement, new clinical question format, and modified recommendations based on the GRADE system.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Hyeong In Ha, Eun-Gyeong Lee, Jiwon Lim, So-Youn Jung, Yoon Jung Chang, Young-Joo Won, Myong Cheol Lim
Summary: The incidence of secondary primary POFT cancer after breast cancer increased in Korea between 1999 and 2017. Second primary POFT cancer patients were diagnosed at older ages and had more serous histology.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Suzanne M. Quartuccio, Subbulakshmi Karthikeyan, Sharon L. Eddie, Daniel D. Lantvit, Eoghainin O. HAinmhire, Dimple A. Modi, Jian-Jun Wei, Joanna E. Burdette
INTERNATIONAL JOURNAL OF CANCER
(2015)
Article
Biochemistry & Molecular Biology
D. A. Modi, R. D. Tagare, S. Karthikeyan, A. Russo, M. Dean, D. A. Davis, D. D. Lantvit, J. E. Burdette
Article
Oncology
Subbulakshmi Karthikeyan, Daniel D. Lantvit, Dam Hee Chae, Joanna E. Burdette
Article
Biochemistry & Molecular Biology
Sezen Meydan, Dorota Klepacki, Subbulakshmi Karthikeyan, Tonu Margus, Paul Thomas, John E. Jones, Yousuf Khan, Joseph Briggs, Jonathan D. Dinman, Nora Vazquez-Laslop, Alexander S. Mankin
Article
Oncology
Subbulakshmi Karthikeyan, Angela Russo, Matthew Dean, Daniel D. Lantvit, Michael Endsley, Joanna E. Burdette
Article
Biotechnology & Applied Microbiology
Shalaka Samant, Gunja Gupta, Subbulakshmi Karthikeyan, Saiful F. Haq, Ayyappan Nair, Ganesh Sambasivam, Sunilkumar Sukumaran
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Saiful F. Haq, Anirudh P. Shanbhag, Subbulakshmi Karthikeyan, Imran Hassan, Kannan Thanukrishnan, Abhishek Ashok, Sunilkumar Sukumaran, S. Ramaswamy, Nagakumar Bharatham, Santanu Datta, Shalaka Samant, Nainesh Katagihallimath
MICROBIAL CELL FACTORIES
(2018)
Article
Oncology
Jose A. Colina, Peter Varughese, Subbulakshmi Karthikeyan, Amrita Salvi, Dimple A. Modi, Joanna E. Burdette