Epigenome Engineering in Cancer: Fairytale or a Realistic Path to the Clinic?

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease

(2014) E. M. Kennedy et al.   JOURNAL OF VIROLOGY

Posttranscriptional Regulation of Gene Expression by Piwi Proteins and piRNAs

(2014) Toshiaki Watanabe et al.   MOLECULAR CELL

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

(2014) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

(2014) Cem Kuscu et al.   NATURE BIOTECHNOLOGY

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

(2014) Hao Yin et al.   NATURE BIOTECHNOLOGY

CRISPR technology for gene therapy

(2014)   NATURE MEDICINE

Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation

(2014) Matthew R. Grimmer et al.   NUCLEIC ACIDS RESEARCH

Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers

(2014) Xuefei Gao et al.   NUCLEIC ACIDS RESEARCH

Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors

(2014) Jiabiao Hu et al.   NUCLEIC ACIDS RESEARCH

Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells

(2014) Suneetha Nunna et al.   PLoS One

RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

(2014) C. Long et al.   SCIENCE

Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

(2014) Sofia Quinodoz et al.   TRENDS IN CELL BIOLOGY

Generation of muscular dystrophy model rats with a CRISPR/Cas system

(2014) Katsuyuki Nakamura et al.   Scientific Reports

Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells

(2014) Zheng Hu et al.   Biomed Research International

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy

(2014) Jason P Ross et al.   Molecular Therapy-Nucleic Acids

Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer

(2013) B T F van der Gun et al.   BRITISH JOURNAL OF CANCER

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Breaking through an epigenetic wall

(2013) Karla Juárez-Moreno et al.   Epigenetics

Cancer genomics identifies disrupted epigenetic genes

(2013) Laia Simó-Riudalbas et al.   HUMAN GENETICS

Upregulation of endogenous ICAM-1 reduces ovarian cancer cell growth in the absence of immune cells

(2013) Marloes L. de Groote et al.   INTERNATIONAL JOURNAL OF CANCER

Towards Sustained Silencing of HER2/neu in Cancer By Epigenetic Editing

(2013) F. Falahi et al.   MOLECULAR CANCER RESEARCH

Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors

(2013) Christian Huisman et al.   Molecular Oncology

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

(2013) Morgan L Maeder et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Locus-specific editing of histone modifications at endogenous enhancers

(2013) Eric M Mendenhall et al.   NATURE BIOTECHNOLOGY

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

The epigenetics pipeline

(2013) Vivian A. DeWoskin et al.   NATURE REVIEWS DRUG DISCOVERY

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

(2013) Hui Chen et al.   NUCLEIC ACIDS RESEARCH

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Proteomic characterization of novel histone post-translational modifications

(2013) Anna M Arnaudo et al.   Epigenetics & Chromatin

Conference Scene: A symphony on C: orchestrating DNA repair for gene expression via cytosine modification

(2013) Marianne G Rots et al.   Epigenomics

Epigenetic drug combination induces genome-wide demethylation and altered gene expression in neuro-ectodermal tumor-derived cell lines

(2013) Floor A.M. Duijkers et al.   CELLULAR ONCOLOGY

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Epigenetic reprogramming of cancer cells via targeted DNA methylation

(2012) Ashley G. Rivenbark et al.   Epigenetics

Targeting Serous Epithelial Ovarian Cancer with Designer Zinc Finger Transcription Factors

(2012) Haydee Lara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

(2012) Julien Valton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a–Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity

(2012) Abu Nasar Siddique et al.   JOURNAL OF MOLECULAR BIOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

The Tale of the TALEs

(2012) E. Pennisi   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression

(2012) Yi Li et al.   Scientific Reports

Modeling gene expression using chromatin features in various cellular contexts

(2012) Xianjun Dong et al.   GENOME BIOLOGY

Targeting DNA With Fingers and TALENs

(2012) Daniel F Carlson et al.   Molecular Therapy-Nucleic Acids

Reactivation ofMASPINin non-small cell lung carcinoma (NSCLC) cells by artificial transcription factors (ATFs)

(2011) Adriana S. Beltran et al.   Epigenetics

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

(2011) G. C. Hon et al.   GENOME RESEARCH

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

(2011) Atanu Maiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

(2011) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

Histone modification: cause or cog?

(2011) Steven Henikoff et al.   TRENDS IN GENETICS

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Histone lysine methylation and demethylation pathways in cancer

(2010) Radhika A. Varier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule

(2010) Bernardina T. F. van der Gun et al.   BIOCONJUGATE CHEMISTRY

Zinc Finger Nucleases as tools to understand and treat human diseases

(2010) David Davis et al.   BMC Medicine

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

(2010) K.-M. Schmitz et al.   GENES & DEVELOPMENT

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae

(2010) Patrick Römer et al.   NEW PHYTOLOGIST

Epigenetic Drugs Can Stimulate Metastasis through Enhanced Expression of the Pro-Metastatic Ezrin Gene

(2010) Yanlin Yu et al.   PLoS One

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

(2009) M. T. McCabe et al.   CLINICAL CANCER RESEARCH

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor

(2008) A. S. Beltran et al.   MOLECULAR CANCER THERAPEUTICS