Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease

The early history of the eosinophil

(2015) A. B. Kay   CLINICAL AND EXPERIMENTAL ALLERGY

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease

(2015) Michael A. Ghebre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

(2015) Osama Eltboli et al.   RESPIROLOGY

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Between-visit variability of small airway obstruction markers in patients with asthma

(2014) S. Gonem et al.   EUROPEAN RESPIRATORY JOURNAL

Eosinophilic inflammation in COPD: prevalence and clinical characteristics: Table 1–

(2014) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4

(2014) James Edward Pease et al.   Expert Opinion on Drug Discovery

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12-month follow-up analysis

(2014) Pranabashis Haldar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma

(2014) Christopher Newby et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety and Efficacy Of ARRY-502, a Potent, Selective, Oral CRTh2 Antagonist, In Patients With Mild To Moderate Th2-Driven Asthma

(2014) Sally E. Wenzel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Potent and Selective CRTH2 Antagonist OC000459 Is Effective In The Treatment Of Eosinophilic Asthma When Given Once Daily

(2014) Roy Pettipher et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials

(2014) Nicola A. Hanania et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Computational modeling of the obstructive lung diseases asthma and COPD

(2014) Kelly Burrowes et al.   Journal of Translational Medicine

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statistical Cluster Analysis of the British Thoracic Society Severe Refractory Asthma Registry: Clinical Outcomes and Phenotype Stability

(2014) Chris Newby et al.   PLoS One

External validation of blood eosinophils, FENOand serum periostin as surrogates for sputum eosinophils in asthma

(2014) A H Wagener et al.   THORAX

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils

(2014) Osama Eltboli et al.   BMC Pulmonary Medicine

Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis

(2014) R. J. B. Loymans et al.   BMJ-British Medical Journal

Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study

(2014) Christopher E Brightling et al.   Lancet Respiratory Medicine

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity

(2014) Francis Davoine et al.   Frontiers in Immunology

Three phenotypes of adult-onset asthma

(2013) M. Amelink et al.   ALLERGY

Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

(2013) Dhananjay Desai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial

(2013) H. Neighbour et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

(2013) Mark Ultsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting eosinophils in allergy, inflammation and beyond

(2013) Patricia C. Fulkerson et al.   NATURE REVIEWS DRUG DISCOVERY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

(2013) Florence N Schleich et al.   BMC Pulmonary Medicine

Eosinophils as diagnostic tools in chronic lung disease

(2013) Osama Eltboli et al.   Expert Review of Respiratory Medicine

Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease

(2012) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

(2012) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

(2012) Roy Pettipher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry: Table 1

(2012) Joan Sweeney et al.   THORAX

Dose-response effects of TPI ASM8 in asthmatics after allergen

(2011) G. M. Gauvreau et al.   ALLERGY

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

(2011) N. Barnes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Benralizumab – a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity – a novel approach for the treatment of asthma

(2011) Aasia Ghazi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment Effects of Low-Dose Theophylline Combined With an Inhaled Corticosteroid in COPD

(2010) Paul A. Ford et al.   CHEST

An update on the role of leukotrienes in asthma

(2010) Teal S Hallstrand et al.   Current Opinion in Allergy and Clinical Immunology

Budesonide/formoterol for maintenance and reliever therapy of asthma: a meta analysis of randomised controlled trials

(2010) S. J. Edwards et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Eosinophil protein in airway macrophages: A novel biomarker of eosinophilic inflammation in patients with asthma

(2010) Neeta S. Kulkarni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

(2009) Helen K. Reddel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytokine and anti-cytokine therapy in asthma: ready for the clinic?

(2009) D. Desai et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway hyperresponsiveness is dissociated from airway wall structural remodeling

(2008) Salman Siddiqui et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

(2008) Shironjit K. Saha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE