Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors

Synthesis of Benzo[4,5]imidazo[2,1-b ]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H -Benzo[d ]imidazole-2-thiol

(2018) Sourav Jana et al.   ADVANCED SYNTHESIS & CATALYSIS

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

(2016) Caroline Shi-Yan Foo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of 6-chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives: Antidiabetic, antioxidant, β -glucuronidase inhibiton and their molecular docking studies

(2016) Muhammad Taha et al.   BIOORGANIC CHEMISTRY

Copper-catalyzed synthesis of benzo[b]thiophene-fused imidazopyridines via the cleavage of C–H bond and C–X bond

(2016) Hui Huang et al.   TETRAHEDRON LETTERS

Isoniazid metabolism and hepatotoxicity

(2016) Pengcheng Wang et al.   Acta Pharmaceutica Sinica B

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

(2015) Vadim Makarov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy

(2015) Qun Cai et al.   CHINESE CHEMICAL LETTERS

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation and fate: an example of the coordinate contribution of lipid oxidation and Maillard reaction to the production and elimination of processing-related food toxicants

(2015) Rosario Zamora et al.   RSC Advances

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

(2014) João Neres et al.   ACS Chemical Biology

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

Trends in discovery of new drugs for tuberculosis therapy

(2014) Giovanna Riccardi et al.   JOURNAL OF ANTIBIOTICS

Discovery of Pyrazolopyridones as a Novel Class of Noncovalent DprE1 Inhibitor with Potent Anti-Mycobacterial Activity

(2014) Manoranjan Panda et al.   JOURNAL OF MEDICINAL CHEMISTRY

The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

(2013) Giovanna Riccardi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents

(2013) Venkatesham Rachakonda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

(2013) Pravin S. Shirude et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Synthesis and biological evaluation of new 13-n-nonylprotoberberine derivatives as antitubercular agents

(2013) Yinghong Li et al.   Acta Pharmaceutica Sinica B

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

(2012) Garrett C. Moraski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

(2012) S. M. Batt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

(2012) J. Neres et al.   Science Translational Medicine

Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents

(2012) Yanxiang Wang et al.   Acta Pharmaceutica Sinica B

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

(2011) Moira L. Bode et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs

(2011) Taleb H. Al-Tel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2

(2011) Nurit Dahan-Farkas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in Mycobacterium siderophore-based drug discovery

(2011) Jun-li He et al.   Acta Pharmaceutica Sinica B

Post Groebke–Blackburn multicomponent protocol: Synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents

(2010) Taleb H. Al-Tel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis

(2010) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

(2009) Luke R. Odell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

(2009) Jeremy T. Starr et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of antibacterial AccC inhibitors

(2009) Cliff C. Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line

(2009) Miguel Angel Martínez-Urbina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): Part II

(2008) Jean-Baptiste Véron et al.   BIOORGANIC & MEDICINAL CHEMISTRY