Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1

SREBP1-driven lipid desaturation supports clear cell renal cell carcinoma growth through regulation of NF-κB signaling

(2018) Hao Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells

(2018) Yuwan Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells

(2018) Tsai-Mu Cheng et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol as MDR reversion molecule in breast cancer: An overview

(2017) Nafiseh Sadat Alamolhodaei et al.   FOOD AND CHEMICAL TOXICOLOGY

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

(2017) Ke Chen et al.   Molecular Cancer

Cancer stem cells: The root of tumor recurrence and metastases

(2017) Claudia Peitzsch et al.   SEMINARS IN CANCER BIOLOGY

Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies

(2017) Michael Yousef et al.   Nutrients

Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines

(2017) Dietmar Zechner et al.   Journal of Cancer

Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment

(2017) Jeffrey Koury et al.   Stem Cells International

Pancreatic Cancer Chemoresistance to Gemcitabine

(2017) Manoj Amrutkar et al.   Cancers

Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs)

(2017) Li Wang et al.   PLoS One

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade

(2016) Zhengle Zhang et al.   CANCER LETTERS

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

(2016) Zhengdong Jiang et al.   Nutrients

Resveratrol in the treatment of pancreatic cancer

(2015) Qinhong Xu et al.   Annals of the New York Academy of Sciences

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer

(2015) Sheema Khan et al.   CANCER RESEARCH

Gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) Yoav Binenbaum et al.   DRUG RESISTANCE UPDATES

Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway

(2015) WEI LI et al.   ONCOLOGY REPORTS

Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation

(2015) Deepak Raj et al.   STEM CELLS

SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism

(2015) Yan Sun et al.   TUMOR BIOLOGY

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

(2015) Jiguang Ma et al.   Oncotarget

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy

(2015) A Borah et al.   Oncogenesis

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway

(2015) Wanxing Duan et al.   Oncotarget

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Metabolism addiction in pancreatic cancer

(2014) R Blum et al.   Cell Death & Disease

Resveratrol Inhibits the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells Via Suppression of the PI-3K/Akt/NF-κB Pathway

(2013) Wei Li et al.   CURRENT MEDICINAL CHEMISTRY

Targeting cancer stem cells to suppress acquired chemotherapy resistance

(2013) S J Vidal et al.   ONCOGENE

The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer

(2013) C Hage et al.   Cell Death & Disease

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine

(2012) Anke Van den broeck et al.   BMC CANCER

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Concise Review: Emerging Concepts in Clinical Targeting of Cancer Stem Cells

(2011) Zeshaan A. Rasheed et al.   STEM CELLS

Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma

(2009) Thilo Welsch et al.   CLINICAL & EXPERIMENTAL METASTASIS

Clinical pharmacology and pharmacogenetics of gemcitabine

(2009) Andrea Wong et al.   DRUG METABOLISM REVIEWS

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players

(2008) M. P. Kim et al.   CLINICAL CANCER RESEARCH