Nitric oxide synthase enzymology in the 20 years after the Nobel Prize

Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

(2018) Elizabeth A. Sweeny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling

(2018) Igor Shamovsky et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells

(2018) Arnab Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial NOS: perspective and recent developments

(2018) Victor Garcia et al.   BRITISH JOURNAL OF PHARMACOLOGY

A perspective on conformational control of electron transfer in nitric oxide synthases

(2017) Tobias M. Hedison et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitric oxide synthase in plants: Where do we stand?

(2017) Jérôme Santolini et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery

(2016) Somasundaram Ramasamy et al.   FEBS Journal

Fluorescence quenching studies of structure and dynamics in calmodulin-eNOS complexes

(2015) David C. Arnett et al.   FEBS LETTERS

Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study

(2015) Yinghong Sheng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics

(2015) Yufan He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating nitric oxide synthase domain interactions by molecular dynamics

(2015) Scott A. Hollingsworth et al.   PROTEIN SCIENCE

Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated Nω-Hydroxy-l-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus

(2014) Roman Davydov et al.   BIOCHEMISTRY

Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles

(2014) Mohammad M. Haque et al.   FEBS Journal

Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

(2014) Adam L. Yokom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Holoenzyme structures of endothelial nitric oxide synthase – An allosteric role for calmodulin in pivoting the FMN domain for electron transfer

(2014) Niels Volkmann et al.   JOURNAL OF STRUCTURAL BIOLOGY

Molecular architecture of mammalian nitric oxide synthases

(2014) M. G. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase

(2013) Mohammad Mahfuzul Haque et al.   BIOCHEMICAL JOURNAL

Reactive Intermediates in Cytochrome P450 Catalysis

(2013) Courtney M. Krest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation

(2013) B. C. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin activates neuronal nitric oxide synthase by enabling transitions between conformational states

(2012) John C. Salerno et al.   FEBS LETTERS

Control of Electron Transfer and Catalysis in Neuronal Nitric-oxide Synthase (nNOS) by a Hinge Connecting Its FMN and FAD-NADPH Domains

(2012) Mohammad Mahfuzul Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors

(2011) Timothy C. Gahman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process

(2011) Arnab Ghosh et al.   FASEB JOURNAL

Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination

(2011) Hwei-Ming Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

(2010) Syed Mohsin Waheed et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Bridging Interaction Allows Calmodulin to Activate NO Synthase through a Bi-modal Mechanism

(2010) Jesús Tejero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase

(2010) Joshua J. Woodward et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pulsed EPR Determination of the Distance between Heme Iron and FMN Centers in a Human Inducible Nitric Oxide Synthase

(2010) Andrei V. Astashkin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

(2010) R. Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Density functional theory (DFT) and combined quantum mechanical/molecular mechanics (QM/MM) studies on the oxygen activation step in nitric oxide synthase enzymes

(2009) Sam P. de Visser   BIOCHEMICAL SOCIETY TRANSACTIONS

Fast ferrous heme-NO oxidation in nitric oxide synthases

(2009) Jesús Tejero et al.   FEBS Journal

Neutralizing a Surface Charge on the FMN Subdomain Increases the Activity of Neuronal Nitric-oxide Synthase by Enhancing the Oxygen Reactivity of the Enzyme Heme-Nitric Oxide Complex

(2009) Mohammad Mahfuzul Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Interdomain Interactions by Calmodulin in Inducible Nitric-oxide Synthase

(2009) Chuanwu Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?

(2009) Zhi-Qiang Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Phosphorylation within an Autoinhibitory Domain in Endothelial Nitric Oxide Synthase Reduces the Ca2+Concentrations Required for Calmodulin To Bind and Activate the Enzyme

(2008) Quang-Kim Tran et al.   BIOCHEMISTRY

Deletion of the autoregulatory insert modulates intraprotein electron transfer in rat neuronal nitric oxide synthase

(2008) Changjian Feng et al.   FEBS LETTERS

Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase

(2008) Chin-Chuan Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the Electron Transfer Properties of Neuronal Nitric-oxide Synthase by Reversal of the FMN Redox Potential

(2008) Huiying Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Second Step of the Nitric Oxide Synthase Reaction: Evidence for Ferric-Peroxo as the Active Oxidant

(2008) Joshua J. Woodward et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY