Article
Chemistry, Analytical
Feicheng Bai, Wei Du, Xia Liu, Lichao Su, Zhi Li, Tao Chen, Xiaoguang Ge, Qingqing Li, Huanghao Yang, Jibin Song
Summary: Researchers have developed a NO-responsive fluorescent nanoprobe for quantitative detection and monitoring of drug-induced liver injury. This nanoprobe can selectively detect NO in vivo, monitor DILI, and screen antidotes for acetaminophen, showing promise for early diagnosis and visualization of liver injury caused by drugs.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chenchen Hu, Fan Jiang, Yixiao Li, Ruiyang Man, Zhengze Yu
Summary: A biomimetic nano-regulator was developed for mutually reinforcing disruption of Ca2+/NO/energy metabolism triple homeostasis in cancer cells, leading to severe cytotoxicity and apoptosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mindaugas Lesanavicius, Jean-Luc Boucher, Narimantas Cenas
Summary: This study aimed to uncover the specific features of neuronal nitric oxide synthase (nNOS) in the reduction of xenobiotics. The reactivity of quinones (Q), aromatic N-oxides (ArN -> O), and nitroaromatic compounds (ArNO2) was found to increase with their single-electron reduction midpoint potential. The binding of calmodulin (CAM) was shown to decrease the electron transfer distance from FMNH2 to quinone. The findings also indicate the importance of nNOS in the bioreduction of quinones and other prooxidant xenobiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Neurosciences
Souparno Ghosh, Nan Li, Benjamin B. Bartelle, Tianshu Xie, Jade Daher, Urvashi D. Singh, Katherine Xie, Nicholas DiNapoli, Nicholas B. Evans, Kwanghun Chung, Alan Jasanoff
Summary: This study introduces a genetic probe that allows selective functional imaging of distributed neural populations. The results reveal the involvement of diverse projection sources in striatal function and provide insights into reward behavior and therapeutic neurostimulation approaches.
NATURE NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Zan Li, Jiao Lu, Qing Pang, Jinmao You
Summary: In this study, a reliable near-infrared ratiometric fluorescent biosensor CDMS was designed and constructed for real-time monitoring of ONOO- fluctuations in tumor progression. The probe demonstrated excellent performance in cellular imaging and in vivo visualization of ONOO- in tumor pathological progression, showing great potential for tumor diagnosis and therapy.
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Pharmacology & Pharmacy
Yue Dai, Dennis J. Stuehr
Summary: The study investigated the changes that occur to sGC during its inactivation in cells using HEK293 cells expressing sGC proteins, where oxidative or nitrosative inactivation of sGC involved sGC heterodimer dissociation and rearrangement of the sGC beta protein partners without any haem loss from sGC beta. Understanding these changes may direct strategies to preserve or recover NO-dependent cGMP signaling in health and disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Andreas Eich, Yaser NejatyJahromy, Olav Schiemann, Johannes Beck
INORGANIC CHEMISTRY COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Jan Philipp Goelz, Yaser NejatyJahromy, Mirko Bauer, Ashraf Muhammad, Gregor Schnakenburg, Stefan Grimme, Olav Schiemann, Dirk Menche
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Biochemical Research Methods
Erik Schubert, Tobias Hettl, Olav Schiemann, Yaser NejatyJahromy
JOURNAL OF MAGNETIC RESONANCE
(2016)
Article
Chemistry, Inorganic & Nuclear
Tobias Heurich, Zheng-Wang Qu, Gregor Schnakenburg, Yaser NejatyJahromy, Olav Schiemann, Stefan Grimme, Rainer Streubel
Article
Chemistry, Inorganic & Nuclear
Knut Wittich, Yaser NejatyJahromy, Dinar Abdullin, Olav Schiemann, Andrey Karpov, Katharina Dobner, Frank Rosowski, Robert Glaum
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2018)
Article
Chemistry, Multidisciplinary
Stefan Stoll, Yaser NejatyJahromy, Joshua J. Woodward, Andrew Ozarowski, Michael A. Marletta, R. David Britt
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2010)
Article
Multidisciplinary Sciences
Jon M. Kuchenreuther, William K. Myers, Troy A. Stich, Simon J. George, Yaser NejatyJahromy, James R. Swartz, R. David Britt
Article
Physics, Atomic, Molecular & Chemical
Yaser NejatyJahromy, Subrata Chandra Roy, Robert Glaum, Olav Schiemann
Summary: Research on the catalytic activity of different structure types of vanadyl(V) orthophosphate has been conducted, with EPR spectroscopy used to elucidate the electronic structure. By utilizing a multi-frequency approach, discrepancies between spectra and simulations were resolved, leading to the reporting of consistent EPR results and refined paramagnetic parameters.
APPLIED MAGNETIC RESONANCE
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Sanie-Jahromi, Yaser NejatyJahromy, Rahim Raoofi Jahromi
Summary: Research has analyzed the infection rates of COVID-19 in different age groups, suggesting that unique stem cell molecular signature in children and pregnant women may lead to milder symptoms; this lays the groundwork for predicting epidemic spread patterns and designing stem cell treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Education & Educational Research
Etrat AlZahra Ghanaat Pisheh, Yaser NejatyJahromy, Rahim Badri Gargari, Touraj Hashemi, Eskandar Fathi-Azar
JOURNAL OF COMPUTER ASSISTED LEARNING
(2019)
Article
Education, Special
Etrat Alzahra Ghanaat Pisheh, Narges Sadeghpour, Yaser Nejatyjahromy, Mir Mahmoud Mir Nasab
SUPPORT FOR LEARNING
(2017)