Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure

Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Drug Exposure

(2018) Andrew Rowland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries

(2018) Madelé van Dyk et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

The Routine Clinical use of Pharmacogenetic Tests: What it Will Require?

(2017) Mafalda M. Dias et al.   PHARMACEUTICAL RESEARCH

CYP3A activity: towards dose adaptation to the individual

(2016) Nicolas Hohmann et al.   Expert Opinion on Drug Metabolism & Toxicology

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

(2015) Mian He et al.   CARCINOGENESIS

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Biological Functions of Exosomes in the Liver in Health and Disease

(2014) Abbas Ali Imani Fooladi et al.   Hepatitis Monthly

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Characterization of Human Thymic Exosomes

(2013) Gabriel Skogberg et al.   PLoS One

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem

(2013) Kathrin Klein et al.   Frontiers in Genetics

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy

(2012) Laure Elens et al.   PHARMACOGENOMICS

Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy

(2011) Pyong-Gon Moon et al.   PROTEOMICS

4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

(2010) Ulf Diczfalusy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β-Hydroxycholesterol

(2008) KP Kanebratt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The "Albumin Effect" and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities

(2008) A. Rowland et al.   DRUG METABOLISM AND DISPOSITION

The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

(2008) A. Rowland et al.   DRUG METABOLISM AND DISPOSITION

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

(2008) Javier Conde-Vancells et al.   JOURNAL OF PROTEOME RESEARCH