pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry

Targeted mass spectrometry enables robust quantification of FANCD2 mono-ubiquitination in response to DNA damage

(2018) Jeffrey R. Whiteaker et al.   DNA REPAIR

A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage

(2018) Jeffrey R. Whiteaker et al.   RADIATION RESEARCH

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

gamma-H2AX: Can it be established as a classical cancer prognostic factor?

(2017) Viktoria-Varvara Palla et al.   TUMOR BIOLOGY

Structures of closed and open conformations of dimeric human ATM

(2017) Domagoj Baretić et al.   Science Advances

Phase I modular study of AZD6738, a novel oral, potent and selective ataxia telangiectasia Rad3-related (ATR) inhibitor in combination (combo) with carboplatin, olaparib or durvalumab in patients (pts) with advanced cancers

(2016) T.A. Yap et al.   EUROPEAN JOURNAL OF CANCER

Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

(2016) Sébastien L. Degorce et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Ataxia-telangiectasia–Mutated Protein Kinase Levels Stratify Patients With Pancreatic Adenocarcinoma Into Prognostic Subgroups With Loss Being a Strong Indicator of Poor Survival

(2015) Carsten Kamphues et al.   PANCREAS

Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma

(2015) Madhuri Bhandaru et al.   PLoS One

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

(2014) Magtouf Gatei et al.   HUMAN MOLECULAR GENETICS

Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

(2014) Steven A. Carr et al.   MOLECULAR & CELLULAR PROTEOMICS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

(2014) H. Al-Ahmadie et al.   Cancer Discovery

A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery

(2013) Neil R Smith et al.   JOURNAL OF PATHOLOGY

Influence of MRE11, RAD50 and NIBRIN protein expression on survival in pancreatic carcinoma after curative resection

(2013) Klemens Horst et al.   PATHOLOGY RESEARCH AND PRACTICE

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

(2012) Remko Prevo et al.   CANCER BIOLOGY & THERAPY

Peptide Immunoaffinity Enrichment Coupled with Mass Spectrometry for Peptide and Protein Quantification

(2011) Jeffrey R. Whiteaker et al.   CLINICS IN LABORATORY MEDICINE

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

(2011) Magtouf Gatei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interlaboratory Evaluation of Automated, Multiplexed Peptide Immunoaffinity Enrichment Coupled to Multiple Reaction Monitoring Mass Spectrometry for Quantifying Proteins in Plasma

(2011) Eric Kuhn et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantification of Proteins Using Peptide Immunoaffinity Enrichment Coupled with Mass Spectrometry

(2011) Lei Zhao et al.   Jove-Journal of Visualized Experiments

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

(2009) E. R.P. Shull et al.   GENES & DEVELOPMENT

Differential Expression of Biomarkers in Primary Non-small Cell Lung Cancer and Metastatic Sites

(2009) Carlos Gomez-Roca et al.   Journal of Thoracic Oncology

DNA Damage Responses: Mechanisms and Roles in Human Disease: 2007 G.H.A. Clowes Memorial Award Lecture

(2008) M. B. Kastan   MOLECULAR CANCER RESEARCH

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY