Article
Plant Sciences
Qun Zhao, Xinran Cheng, Wei Yu, Yun Bi, Jian Guo, Qingzhao Ma, Yingxia Gong, Li He, Xianjun Yu
Summary: Pristimerin exhibits potent antitumor activity against various cancers and can inhibit the proliferation of human OSCC cell lines by inducing apoptosis through endoplasmic reticulum stress activation and JNK signaling. Pri also suppresses tumor growth in OSCC xenografts, suggesting its potential therapeutic use for OSCC.
Article
Cell Biology
Wentao Huang, Hongjing Liu, Tianzhu Lv
Summary: The study showed that SETD6 is significantly upregulated in oral squamous cell carcinoma (OSCC) tissues. Silencing SETD6 inhibited proliferation, migration, and invasion of OSCC cells, induced apoptosis, and resulted in G1 arrest. Additionally, SETD6 siRNA also suppressed promoter methylation of RelA and PAK4.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiang-shuang Chang, Jing Zhu, Tao Yang, Ying Gao
Summary: The study aimed to explore the functional role of miR-524 in oral squamous cell carcinoma (OSCC) and determine its underlying mechanism. Results showed that miR-524 expression was significantly decreased in OSCC tissues and closely related to clinical stage, tumor size, and lymph node metastasis. Over-expression of miR-524 suppressed the proliferation, migration, and invasion of OSCC cells by targeting MTDH and inhibiting the NF-κB signaling pathway.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Cell Biology
Hyung-Mun Yun, Bomi Kim, Soo Hyun Kim, Seung-Hae Kwon, Kyung-Ran Park
Summary: In this study, xanol was purified from A. keiskei and found to inhibit cell proliferation and induce cytotoxicity in human OSCC. Xanol triggered apoptotic cell death and inhibited necroptotic cell death in human OSCC. Xanol also inhibited the PI3K/AKT/mTOR/p70S6K pathway, induced autophagosome formation, and prevented the metastatic phenotypes of human OSCC. Furthermore, xanol exerted anticancer effects on tumorigenicity associated with its transformed properties.
Article
Biochemistry & Molecular Biology
Hyung-Mun Yun, Yoon-Ju Kwon, Eonmi Kim, Hea-Jong Chung, Kyung-Ran Park
Summary: In this study, Machilin D (Mach), a lignin, was isolated from the roots of Saururus chinensis and its inhibitory effects on oral squamous cell carcinoma (OSCC) were assessed. Mach exhibited significant cytotoxicity against human OSCC cells and inhibited cell adhesion, migration, and invasion by targeting adhesion molecules, including the FAK/Src pathway. Mach also suppressed multiple signaling pathways, including the PI3K/AKT/mTOR/p70S6K pathway and MAPKs, leading to apoptotic cell death. Moreover, Mach induced autophagy and inhibited necroptosis, further enhancing its inhibitory effects on OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Feng
Summary: This study investigated the anti-tumor activity of a PKM2 inhibitor called MTP in oral squamous cell carcinoma cells. The results showed that MTP inhibited cell growth, induced apoptosis, and modulated the expression of PKM2 and oncogenic biomarkers. In addition, MTP increased reactive oxygen species generation and affected the expression of autophagic genes. These findings suggest that MTP has potential therapeutic use for oral squamous cell carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Juan Du, Wenjing Su, Xiaoguang Li, Tingjian Zu, Jinbo Bai, Weidong Zhang, Wei Zhou
Summary: In this study, the function of the long non-coding RNA LINC00525 in the progression of oral squamous cell carcinoma (OSCC) was investigated through in vitro and in vivo experiments. The results showed that LINC00525 was associated with OSCC survival and prognosis. Knockdown of LINC00525 decreased cell viability, migration and invasion properties, and increased apoptosis in OSCC cells. In vivo experiments also demonstrated that downregulation of LINC00525 reduced OSCC tumour growth. Therefore, LINC00525 may serve as a potential target for the treatment of OSCC.
Article
Cell Biology
Zhi Cui, Shiqun Sun, Jia Li, Jianing Li, Tong Sha, Jie He, Linjing Zuo
Summary: This study found that UBE2L3 is overexpressed in HNSCC and its overexpression is associated with poor prognosis. In vitro experiments further demonstrated that UBE2L3 overexpression promotes proliferation, invasion, migration, and tumor growth in HNSCC cells. The study also revealed that UBE2L3 activates the NF-κB signaling pathway and is negatively regulated by miR-378a-5p. Therefore, UBE2L3 may be a potential therapeutic target for the treatment of HNSCC.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Environmental Sciences
Po-Chen Chu, Eman M. E. Dokla, Jing-Lan Hu, Jing-Ru Weng
Summary: This study investigated the antitumor activity and underlying mechanisms of a novel YAP inhibitor, ATN, in oral squamous cell carcinoma (OSCC) cells. ATN showed strong antiproliferative and antimigration effects in OSCC cells, which were mediated through regulation of the YAP signaling pathway and Mcl-1 expression.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vishal Sharad Chaudhari, Basveshwar Gawali, Pritam Saha, V. G. M. Naidu, Upadhyayula Suryanarayana Murty, Subham Banerjee
Summary: The study encapsulated herbal components like piperine and quercetin into nanostructured lipid carriers (NLCs) to enhance their anticancer potential against oral squamous cellular carcinoma (OSCC). The dual drug-loaded NLCs showed improved cellular internalization, induction of apoptosis, and distribution within the oral cavity, providing a more effective treatment option for oral cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jiaqi Chen, Ziyu Zhu, Qiaoya Pan, Yang Bai, Mengfei Yu, Yi Zhou
Summary: In this study, a novel nanoparticle Co-Fc@HCQ was successfully synthesized, which achieved targeted therapy for oral squamous cell carcinoma by inhibiting autophagy and enhancing the generation of reactive oxygen species.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rossella Basilotta, Marika Lanza, Alessia Filippone, Giovanna Casili, Deborah Mannino, Federica De Gaetano, Giulia Chisari, Lorenzo Colarossi, Gianmarco Motta, Michela Campolo, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Oral squamous cell carcinoma (OSCC) is a common human tumor with a high mortality rate. Existing treatments for OSCC have poor survival outcomes, so there is a need for new therapeutic strategies. This study found that dimethyl fumarate (DMF) could reduce the expression of anti-apoptotic factors, modulate oxidative stress, and inhibit tumor cell migration, making it a promising strategy to counteract oral cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maho Onda, Akinobu Ota, Kunihiro Ito, Takayuki Ono, Sivasundaram Karnan, Mikako Kato, Sayuri Kondo, Akifumi Furuhashi, Tomio Hayashi, Yoshitaka Hosokawa, Yoshiaki Kazaoka
Summary: Disruption of EGFR signaling significantly decreased the proliferation and oncogenic signaling in OSCC cells. VEGFR inhibitors continued to inhibit the proliferation of EGFR-deficient OSCC cells, and CRISPR-mediated disruption of KDR/VEGFR2 retarded OSCC cell proliferation. Combined erlotinib-vatalanib treatment exhibited a more potent anti-proliferative effect on OSCC cells.
Article
Oncology
Hsin-Chieh Lin, Chih-Chun Wang, Ching-Fang Wu, Yuan-Ho Lin, Wei-Chang Lee, Po-Jen Chen, Yu Chang, Yu-Chieh Su
Summary: This study aimed to investigate the effect of hinokitiol on cell viability in oral squamous cell carcinoma (OSCC) cells. The results showed that hinokitiol can downregulate the levels of cell-cycle mediators, reduce cell viability, promote apoptosis, and induce autophagy in OSCC cell lines.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang, Dengke Bao
Summary: The study demonstrated that ivermectin significantly inhibits the proliferation of ESCC cells and induces apoptosis. Mechanistically, ivermectin induces mitochondrial dysfunction and apoptosis pathway, leading to apoptosis of ESCC cells.