LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition

Parthenolide suppresses hypoxia-inducible factor-1α signaling and hypoxia induced epithelial-mesenchymal transition in colorectal cancer

(2017) Se Lim Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

(2017) Hongzhe Li et al.   Molecular Cancer

Upholding a role for EMT in breast cancer metastasis

(2017) Xin Ye et al.   NATURE

Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma

(2017) Cecilia Ranhem et al.   PLoS One

Systemic Therapy for Metastatic Melanoma in 2012: Dawn of a New Era

(2017) Shailender Bhatia et al.   Journal of the National Comprehensive Cancer Network

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons

(2016) Bing Li et al.   MOLECULAR NEUROBIOLOGY

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

LRIG1 inhibits hypoxia-induced vasculogenic mimicry formation via suppression of the EGFR/PI3K/AKT pathway and epithelial-to-mesenchymal transition in human glioma SHG-44 cells

(2015) Xi Zhang et al.   CELL STRESS & CHAPERONES

Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer

(2015) Yuzhi An et al.   MEDICINE

LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells

(2015) N Yokdang et al.   ONCOGENE

Hypoxia as a Cause of Treatment Failure in Non–Small Cell Carcinoma of the Lung

(2015) Odd Terje Brustugun   SEMINARS IN RADIATION ONCOLOGY

Loss of LRIG1 Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer

(2014) P. A. Thompson et al.   CANCER RESEARCH

Hypoxia promotes vasculogenic mimicry formation by inducing epithelial–mesenchymal transition in ovarian carcinoma

(2014) Jing Du et al.   GYNECOLOGIC ONCOLOGY

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

(2014) Erik O. Pettersen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

ME-12 * THE TUMOR SUPPRESSOR LRIG1 IS DOWNREGULATED BY HYPOXIA AND REGULATES GLIOBLASTOMA CELL INVASION

(2014) F. Mao et al.   NEURO-ONCOLOGY

Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation

(2014) Laura Asnaghi et al.   PLoS One

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

(2014) Twan van den Beucken et al.   Nature Communications

Restoration of LRIG1 suppresses bladder cancer cell growth by directly targeting EGFR activity

(2013) Lei Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Downregulation of LRIG1 expression by RNA interference promotes the aggressive properties of glioma cells via EGFR/Akt/c-Myc activation

(2012) RUIFAN XIE et al.   ONCOLOGY REPORTS

Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes

(2010) Sigrid Rouam et al.   BMC BIOINFORMATICS