Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid

(2018) Qiuchen Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

(2018) Igor V. Kurochkin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme

(2018) Claire A. Krasinski et al.   ACS Chemical Neuroscience

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Extending Halogen-based Medicinal Chemistry to Proteins

(2016) Krystel El Hage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

(2016) Wei-Jen Tang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearancein Vivo

(2015) Timothy B. Durham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

(2015) Sandeep K. Sharma et al.   Scientific Reports

Biophysical Optimization of a Therapeutic Protein by Nonstandard Mutagenesis

(2014) Vijay Pandyarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Dynamics Simulations Reveal a Novel Mechanism for ATP Inhibition of Insulin Degrading Enzyme

(2014) Carlos H. B. da Cruz et al.   Journal of Chemical Information and Modeling

Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges

(2013) Francesco Bellia et al.   JOURNAL OF MASS SPECTROMETRY

Halogen bonding and other σ-hole interactions: a perspective

(2013) Peter Politzer et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

(2013) Lauren A. McCord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anion Activation Site of Insulin-degrading Enzyme

(2011) Nicholas Noinaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Allosteric Regulatory Site of Insulysin

(2011) Nicholas Noinaj et al.   PLoS One

Mechanistic Studies of Peptide Self-Assembly: Transient α-Helices to Stable β-Sheets

(2010) Gai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

(2009) Marika Manolopoulou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study

(2009) Giuseppe Grasso et al.   JOURNAL OF MASS SPECTROMETRY

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

(2009) Qing Guo et al.   JOURNAL OF MOLECULAR BIOLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Time-dependent insulin oligomer reaction pathway prior to fibril formation: Cooling and seeding

(2009) Mirco Sorci et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

On the nucleation of amyloid β-protein monomer folding

(2005) Noel D. Lazo et al.   PROTEIN SCIENCE