Evaluation of the effect of 2′-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice

Published 2018 View Full Article

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Title
Evaluation of the effect of 2′-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice
Authors
Keywords
GalNAc, FHNA Gapmer ASO, Morpholin ASO, 2′-, O, -Me Gapmer ASO, cEt BNA Gapmer ASO, LNA Gapmer ASO, Mixed wing Gapmer ASO
Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 28, Issue 23-24, Pages 3774-3779
Publisher
Elsevier BV
Online
2018-10-11
DOI
10.1016/j.bmcl.2018.10.011

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