Evaluation of the effect of 2′-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice

标题
Evaluation of the effect of 2′-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice
作者
关键词
GalNAc, FHNA Gapmer ASO, Morpholin ASO, 2′-, O, -Me Gapmer ASO, cEt BNA Gapmer ASO, LNA Gapmer ASO, Mixed wing Gapmer ASO
出版物
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 28, Issue 23-24, Pages 3774-3779
出版商
Elsevier BV
发表日期
2018-10-11
DOI
10.1016/j.bmcl.2018.10.011

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