Diversification of importin-α isoforms in cellular trafficking and disease states
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Title
Diversification of importin-α isoforms in cellular trafficking and disease states
Authors
Keywords
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Journal
BIOCHEMICAL JOURNAL
Volume 466, Issue 1, Pages 13-28
Publisher
Portland Press Ltd.
Online
2015-02-06
DOI
10.1042/bj20141186
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Note: Only part of the references are listed.- Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin α Isoforms 3 and 7
- (2015) Ruth A. Pumroy et al. STRUCTURE
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- (2014) Wei Xu et al. Cell Host & Microbe
- The α-importome of mammalian germ cell maturation provides novel insights for importin biology
- (2014) Arash Arjomand et al. FASEB JOURNAL
- Nuclear import of human histone lysine-specific demethylase LSD1
- (2014) Yanhua Jin et al. JOURNAL OF BIOCHEMISTRY
- KPNA2 predicts long term survival in patients with anaplastic oligoastrocytomas
- (2014) Konstantinos Gousias et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Importin-α7 Is Required for Enhanced Influenza A Virus Replication in the Alveolar Epithelium and Severe Lung Damage in Mice
- (2014) Patricia Resa-Infante et al. JOURNAL OF VIROLOGY
- 3Cpro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation
- (2014) Y. Du et al. JOURNAL OF VIROLOGY
- Identification of Importin α 7 Specific Transport Cargoes Using a Proteomic Screening Approach
- (2014) Stefanie Hügel et al. MOLECULAR & CELLULAR PROTEOMICS
- Identification and characterization of multiple conserved nuclear localization signals within adenovirus E1A
- (2014) Kris S. Marshall et al. VIROLOGY
- Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells
- (2014) Aviad Levin et al. Nucleus
- Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
- (2013) Gergely Róna et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
- (2013) M.Y.F. Tay et al. ANTIVIRAL RESEARCH
- Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress
- (2013) Mariya Misheva et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Systemic Delivery of MicroRNA-181b Inhibits Nuclear Factor-κB Activation, Vascular Inflammation, and Atherosclerosis in Apolipoprotein E–Deficient Mice
- (2013) Xinghui Sun et al. CIRCULATION RESEARCH
- Importin Alpha Subtypes Determine Differential Transcription Factor Localization in Embryonic Stem Cells Maintenance
- (2013) Noriko Yasuhara et al. DEVELOPMENTAL CELL
- KPNA3Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence
- (2013) Charles P. Morris et al. DISEASE MARKERS
- Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation
- (2013) Alex R Paciorkowski et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro
- (2013) Eeva Laurila et al. EXPERIMENTAL CELL RESEARCH
- Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport
- (2013) Chelsi J. Snow et al. JOURNAL OF CELL BIOLOGY
- Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal
- (2013) H. Y. Shin et al. JOURNAL OF CELL SCIENCE
- Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells
- (2013) A. C. Sims et al. JOURNAL OF VIROLOGY
- Porcine Reproductive and Respiratory Syndrome Virus Nsp1 Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin- 1 Degradation
- (2013) R. Wang et al. JOURNAL OF VIROLOGY
- MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin α4 and α5 in IgA nephropathy
- (2013) Hao Bao et al. KIDNEY INTERNATIONAL
- Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function
- (2013) Wenduo Ye et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner
- (2013) Zhengke Li et al. PLoS One
- Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
- (2013) Noelia Roman et al. PLoS One
- Chikungunya virus capsid protein contains nuclear import and export signals
- (2013) Saijo Thomas et al. Virology Journal
- KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a
- (2013) L Huang et al. Cell Death & Disease
- Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence
- (2013) Jozef Zienkiewicz et al. Journal of the American Heart Association
- Structural basis of nuclear import of flap endonuclease 1 (FEN1)
- (2012) Andrea C. de Barros et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- (2012) Nan Song et al. ANGIOGENESIS
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- (2012) Kylie M. Wagstaff et al. BIOCHEMICAL JOURNAL
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- (2012) Yoichi Miyamoto et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The nuclear import machinery is a determinant of influenza virus host adaptation
- (2012) Patricia Resa-Infante et al. BIOESSAYS
- Phosphorylation meets nuclear import: a review
- (2012) Jonathan D Nardozzi et al. Cell Communication and Signaling
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- (2012) Reinhard Depping et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Axonal transcription factors signal retrogradely in lesioned peripheral nerve
- (2012) Keren Ben-Yaakov et al. EMBO JOURNAL
- Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ
- (2012) Jieliang Chen et al. HEPATOLOGY
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- (2012) K. Gousias et al. JOURNAL OF NEURO-ONCOLOGY
- ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
- (2012) Weiwei Yang et al. NATURE CELL BIOLOGY
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- (2012) Yan Zhen et al. TRAFFIC
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- (2012) Mary Marfori et al. TRAFFIC
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- (2012) Carolyn P. Paterson et al. VIROLOGY
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- (2012) Ben Hudjetz et al. PLoS Pathogens
- Importin-α1 as a Novel Prognostic Target for Hepatocellular Carcinoma
- (2011) Kenichiro Yoshitake et al. ANNALS OF SURGICAL ONCOLOGY
- Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells
- (2011) C Zhong et al. CELL DEATH AND DIFFERENTIATION
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- (2011) A. Mortezavi et al. CLINICAL CANCER RESEARCH
- High Expression of Karyopherin-α2 Defines Poor Prognosis in Non–Muscle-Invasive Bladder Cancer and in Patients with Invasive Bladder Cancer Undergoing Radical Cystectomy
- (2011) Jørgen Bjerggaard Jensen et al. EUROPEAN UROLOGY
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- (2011) Masashi Okada et al. EXPERIMENTAL CELL RESEARCH
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- (2011) Tetsuji Moriyama et al. FEBS Journal
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- Dimerization of Vaccinia Virus VH1 Is Essential for Dephosphorylation of STAT1 at Tyrosine 701
- (2011) Adem C. Koksal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Soma Ghosh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Stephane Boivin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin α1
- (2011) Kaylen Lott et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Reed S. Shabman et al. JOURNAL OF INFECTIOUS DISEASES
- Structural Basis of Importin-α-Mediated Nuclear Transport for Ku70 and Ku80
- (2011) Agnes A.S. Takeda et al. JOURNAL OF MOLECULAR BIOLOGY
- KPNA6 (Importin 7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response
- (2011) Z. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- Importin -Mediated Nuclear Import of Cytoplasmic Poly(A) Binding Protein Occurs as a Direct Consequence of Cytoplasmic mRNA Depletion
- (2011) G. R. Kumar et al. MOLECULAR AND CELLULAR BIOLOGY
- Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors
- (2011) Rashid Mehmood et al. MOLECULAR BIOLOGY OF THE CELL
- Importin α7 Is Essential for Zygotic Genome Activation and Early Mouse Development
- (2011) Franziska Rother et al. PLoS One
- Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity
- (2011) Pauline J. van der Watt et al. PLoS One
- Nuclear Exportin Receptor CAS Regulates the NPI-1–Mediated Nuclear Import of HIV-1 Vpr
- (2011) Eri Takeda et al. PLoS One
- Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus
- (2011) Gülsah Gabriel et al. Nature Communications
- Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells
- (2010) Y. Zhou et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Nuclear Import of Serum Response Factor in Airway Smooth Muscle
- (2010) John F. McConville et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa
- (2010) Kumara Dissanayake et al. BIOCHEMICAL JOURNAL
- The importin β binding domain as a master regulator of nucleocytoplasmic transport
- (2010) Kaylen Lott et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors
- (2010) Joshua B Kelley et al. BMC CELL BIOLOGY
- An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway
- (2010) Gennadi V. Glinsky CELL CYCLE
- Notch1 signaling is mediated by importins alpha 3, 4, and 7
- (2010) Kerstin Huenniger et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome
- (2010) Chun-I. Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening
- (2010) Sundy N. Y. Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity
- (2010) Chrisovalantis Papadopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Binding of the Mitotic Regulator TPX2 (Target Protein forXenopusKinesin-like Protein 2) to Importin-α
- (2010) Astrid Giesecke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Importin-α Family Member Kpna7 Is Required for Normal Fertility and Fecundity in the Mouse
- (2010) Jianjun Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nuclear Import Mechanism for Myocardin Family Members and Their Correlation with Vascular Smooth Muscle Cell Phenotype
- (2010) Seiji Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Live Cell Imaging Reveals Continuous STAT6 Nuclear Trafficking
- (2010) H.-C. Chen et al. JOURNAL OF IMMUNOLOGY
- Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin α5
- (2010) Jonathan Nardozzi et al. JOURNAL OF MOLECULAR BIOLOGY
- Importin 3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication
- (2010) Z. Ao et al. JOURNAL OF VIROLOGY
- Overexpression of Karyopherin-2 in Epithelial Ovarian Cancer and Correlation With Poor Prognosis
- (2010) Min Zheng et al. OBSTETRICS AND GYNECOLOGY
- Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures
- (2010) Jade K. Forwood et al. STRUCTURE
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- (2010) Xue-Lin Bian et al. VIRUS RESEARCH
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- (2010) S. R. Wente et al. Cold Spring Harbor Perspectives in Biology
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- (2009) Jyothsna Tejomurtula et al. BIOLOGY OF REPRODUCTION
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- (2009) Shaoyi Huang et al. BIOSCIENCE REPORTS
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- (2009) N D Marchenko et al. CELL DEATH AND DIFFERENTIATION
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- (2009) Nima Melzer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Adem C. Koksal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) D. Adam Mason et al. JOURNAL OF MOLECULAR EVOLUTION
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- (2009) Arianne L. Theiss et al. MOLECULAR BIOLOGY OF THE CELL
- Nuclear-Cytoplasmic Shuttling of Chibby Controls β-Catenin Signaling
- (2009) Feng-Qian Li et al. MOLECULAR BIOLOGY OF THE CELL
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- (2009) Carrie Simkus et al. MOLECULAR IMMUNOLOGY
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- (2009) Danya Liu et al. MOLECULAR THERAPY
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- (2009) Stefan Maas et al. NUCLEIC ACIDS RESEARCH
- Identification of Essential Sequences for Cellular Localization in BRMS1 Metastasis Suppressor
- (2009) José Rivera et al. PLoS One
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- (2009) Rotem Ben-Tov Perry et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Caspase-mediated cleavage of importin-α increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin
- (2008) Byung Ju Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2008) Sandra S Haenni et al. BMC CELL BIOLOGY
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- (2008) Riku Fagerlund et al. CELLULAR SIGNALLING
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- (2008) Shunichi Kosugi et al. CHEMISTRY & BIOLOGY
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- (2008) Chengchen Lufei et al. FEBS LETTERS
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- (2008) Minoru Hatayama et al. HUMAN MOLECULAR GENETICS
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- (2008) Pauline J. van der Watt et al. INTERNATIONAL JOURNAL OF CANCER
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- (2008) S. L. Taylor et al. JOURNAL OF VIROLOGY
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- (2008) K. Hosokawa et al. NEUROSCIENCE
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- (2008) K.-O. Lai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) Ulrich Zachariae et al. STRUCTURE
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- (2008) Misty R. Jenkins et al. VIRAL IMMUNOLOGY
- Daxx contains two nuclear localization signals and interacts with importin α3
- (2007) Percy Luk Yeung et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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