Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent Modifications

DNA Methylation and Histone Modification in Hypertension

(2018) Shaunrick Stoll et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

Atorvastatin treatment modulates p16 promoter methylation to regulate p16 expression

(2017) Boqian Zhu et al.   FEBS Journal

The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence

(2017) Yang Lu et al.   Scientific Reports

Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution

(2017) Rui Ding et al.   Scientific Reports

Hypoxic reprograming of H3K27me3 and H3K4me3 at the INK4A locus

(2016) Soojeong Chang et al.   FEBS LETTERS

MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence

(2016) Raphaël Culerrier et al.   MOLECULAR BIOLOGY OF THE CELL

Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7

(2016) Chunyan Ren et al.   ACS Medicinal Chemistry Letters

Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers

(2016) Lili Li et al.   Scientific Reports

Distinct susceptibility of induction of methylation of p16ink4a and p19arf CpG islands by X-radiation and chemical carcinogen in mice

(2014) Chen Yang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells

(2014) Aki Fujiwara-Igarashi et al.   RESEARCH IN VETERINARY SCIENCE

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure

(2014) Elisabeth Wachter et al.   eLife

Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation

(2013) Dexiao Yuan et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation

(2012) Xiuli Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promoter and histone methylation and p16INK4A gene expression in colon cancer

(2012) EBRU ESIN YORUKER et al.   Experimental and Therapeutic Medicine

Hypermethylation of p16 and DAPK promoter gene regions in patients with non-invasive urinary bladder cancer

(2011) Zbigniew Jabłonowski et al.   Archives of Medical Science

Regulatory Mechanisms of Tumor Suppressor P16INK4Aand Their Relevance to Cancer

(2011) Junan Li et al.   BIOCHEMISTRY

Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer

(2011) Youwei Zhang et al.   CANCER LETTERS

Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein

(2011) Nataliya Nady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Atr Protein Kinase Controls UV-Dependent Upregulation of p16INK4A Through Inhibition of Skp2-Related Polyubiquitination/Degradation

(2011) H. H. Al-Khalaf et al.   MOLECULAR CANCER RESEARCH

MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

(2011) Anita A. Thambirajah et al.   NUCLEIC ACIDS RESEARCH

IKKβ specifically binds to P16 and phosphorylates Ser8 of P16

(2010) Yi Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study

(2009) J. Cao et al.   CLINICAL CANCER RESEARCH

The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence

(2009) Yunpeng Feng et al.   FEBS Journal

Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning

(2009) Rebecca A. Hinshelwood et al.   HUMAN MOLECULAR GENETICS

Functional impairment of p16INK4A due to CDKN2A p.Gly23Asp missense mutation

(2009) Maria Chiara Scaini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

YY1 restrained cell senescence through repressing the transcription of p16

(2008) Xiuli Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification

(2008) S. Majid et al.   CANCER RESEARCH

Radionuclides in cigarettes may lead to carcinogenesis via p16INK4a inactivation

(2008) Robyn L. Prueitt et al.   JOURNAL OF ENVIRONMENTAL RADIOACTIVITY