Ghrelin octanoylation by ghrelin O-acyltransferase: Unique protein biochemistry underlying metabolic signaling

Functional group and stereochemical requirements for substrate binding by ghrelin O -acyltransferase revealed by unnatural amino acid incorporation

(2018) Elizabeth R. Cleverdon et al.   BIOORGANIC CHEMISTRY

β-Oxidation in ghrelin-producing cells is important for ghrelin acyl-modification

(2018) Chika Ikenoya et al.   Scientific Reports

Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans

(2018) Muhammad I. ul Akbar Yousufzai et al.   Translational Psychiatry

Dietary caprylic acid and ghrelin O-acyltransferase activity to modulate octanoylated ghrelin functions: What is new in this nutritional field?

(2018) Fanny Lemarié et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Crystal structure of a membrane-bound O-acyltransferase

(2018) Dan Ma et al.   NATURE

Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus

(2017) Mohammad I. Murtuza et al.   JOURNAL OF NEUROCHEMISTRY

Ghrelin-Reactive Immunoglobulins in Conditions of Altered Appetite and Energy Balance

(2017) Sergueï O. Fetissov et al.   Frontiers in Endocrinology

Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors

(2017) Mariko Yoneyama-Hirozane et al.   SLAS Discovery

Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation

(2017) Anna L. Hopkins et al.   Scientific Reports

Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration

(2016) F. Lemarié et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates

(2016) Kayleigh R. McGovern-Gooch et al.   ENDOCRINOLOGY

Ghrelin binding to serum albumin and its biological impact

(2016) Daniela Lufrano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

High-fat diet increases ghrelin-expressing cells in stomach, contributing to obesity

(2016) Marie François et al.   NUTRITION

Structure–Activity Analysis of Human Ghrelin O-Acyltransferase Reveals Chemical Determinants of Ghrelin Selectivity and Acyl Group Recognition

(2015) Joseph E. Darling et al.   BIOCHEMISTRY

A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups

(2015) Feifei Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs

(2015) Martin S. Taylor et al.   BIOORGANIC CHEMISTRY

Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet

(2015) Chi H.L. Dinh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neonatal ghrelin programs development of hypothalamic feeding circuits

(2015) Sophie M. Steculorum et al.   JOURNAL OF CLINICAL INVESTIGATION

Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet

(2015) Danielle Camer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat

(2015) Fanny Lemarié et al.   PLoS One

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

Ghrelin Is a Novel Regulator of GLP-1 Secretion

(2014) Jeffrey Gagnon et al.   DIABETES

Ghrelin signalling inβ-cells regulates insulin secretion and blood glucose

(2014) T. Yada et al.   DIABETES OBESITY & METABOLISM

Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein

(2014) Antonio D. Konitsiotis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology of Hedgehog Acyltransferase

(2014) Armine Matevossian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A fluorescent peptide substrate facilitates investigation of ghrelin recognition and acylation by ghrelin O-acyltransferase

(2013) Joseph E. Darling et al.   ANALYTICAL BIOCHEMISTRY

Architectural Organization of the Metabolic Regulatory Enzyme GhrelinO-Acyltransferase

(2013) Martin S. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

(2013) R M Meyer et al.   MOLECULAR PSYCHIATRY

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

(2013) Kuniko Takagi et al.   Nature Communications

Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids

(2012) Robert Lin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling

(2011) Lenka Doubravska et al.   CELLULAR SIGNALLING

A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

(2011) Amanda L. Garner et al.   CHEMICAL COMMUNICATIONS

Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease

(2011) Manuel D. Gahete et al.   PEPTIDES

Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics

(2011) Junko Yoh et al.   REGULATORY PEPTIDES

cat-ELCCA: A Robust Method To Monitor the Fatty Acid Acyltransferase Activity of Ghrelin O-Acyltransferase (GOAT)

(2010) Amanda L. Garner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

(2010) J. Tong et al.   DIABETES

GOAT: the master switch for the ghrelin system?

(2010) Amparo Romero et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice andLeprdb/dbMice

(2010) Pradip K. Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor

(2009) Hideko Ohgusu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Production of n-octanoyl-modified Ghrelin in Cultured Cells Requires Prohormone Processing Protease and Ghrelin O-acyltransferase, as well as n-octanoic Acid

(2009) Tomoko Takahashi et al.   JOURNAL OF BIOCHEMISTRY

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Acyltransferases for secreted signalling proteins (Review)

(2009) Shu-Chun Chang et al.   MOLECULAR MEMBRANE BIOLOGY

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Circulating ghrelin exists in both lipoprotein bound and free forms

(2009) E Holmes et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE

At the Cutting Edge: Ghrelin Gene Products in Food Intake and Gut Motility

(2008) Chih-Yen Chen et al.   NEUROENDOCRINOLOGY

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides

(2008) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

(2007) Paul T. Pfluger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance

(2007) Yuxiang Sun et al.   ENDOCRINOLOGY

Ghrelin deficiency does not influence feeding performance

(2007) Takahiro Sato et al.   REGULATORY PEPTIDES