Recent insights into lytic polysaccharide monooxygenases (LPMOs)

How a Lytic Polysaccharide Monooxygenase Binds Crystalline Chitin

(2018) Bastien Bissaro et al.   BIOCHEMISTRY

Multipoint Precision Binding of Substrate Protects Lytic Polysaccharide Monooxygenases from Self-Destructive Off-Pathway Processes

(2018) Jennifer S. M. Loose et al.   BIOCHEMISTRY

A Random-Sequential Kinetic Mechanism for Polysaccharide Monooxygenases

(2018) John A. Hangasky et al.   BIOCHEMISTRY

Uncovering the molecular mechanisms of lignocellulose digestion in shipworms

(2018) Federico Sabbadin et al.   Biotechnology for Biofuels

Laccase-derived lignin compounds boost cellulose oxidative enzymes AA9

(2018) Lívia Brenelli et al.   Biotechnology for Biofuels

Real-time imaging reveals that lytic polysaccharide monooxygenase promotes cellulase activity by increasing cellulose accessibility

(2018) Bo Song et al.   Biotechnology for Biofuels

Redox processes acidify and decarboxylate steam-pretreated lignocellulosic biomass and are modulated by LPMO and catalase

(2018) Ausra Peciulyte et al.   Biotechnology for Biofuels

A fast and sensitive activity assay for lytic polysaccharide monooxygenase

(2018) Erik Breslmayr et al.   Biotechnology for Biofuels

Copper active site in polysaccharide monooxygenases

(2018) Van V. Vu et al.   COORDINATION CHEMISTRY REVIEWS

Structural and molecular dynamics studies of a C1-oxidizing lytic polysaccharide monooxygenase from Heterobasidion irregulare reveal amino acids important for substrate recognition

(2018) Bing Liu et al.   FEBS Journal

Production of functionalised chitins assisted by fungal lytic polysaccharide monooxygenase

(2018) Damao Wang et al.   GREEN CHEMISTRY

The carbohydrate-binding module and linker of a modular lytic polysaccharide monooxygenase promote localized cellulose oxidation

(2018) Gaston Courtade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

(2018) Marie Couturier et al.   Nature Chemical Biology

Reactivity of O2versus H2O2with polysaccharide monooxygenases

(2018) John A. Hangasky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of the N-terminal histidine protects a lytic polysaccharide monooxygenase from auto-oxidative inactivation

(2018) Dejan M. Petrovi et al.   PROTEIN SCIENCE

Molecular mechanism of lytic polysaccharide monooxygenases

(2018) Erik Donovan Hedegård et al.   Chemical Science

An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion

(2018) Federico Sabbadin et al.   Nature Communications

QM/MM Studies into the H2O2-Dependent Activity of Lytic Polysaccharide Monooxygenases: Evidence for the Formation of a Caged Hydroxyl Radical Intermediate

(2018) Binju Wang et al.   ACS Catalysis

Enzyme mediated nanofibrillation of cellulose by the synergistic actions of an endoglucanase, lytic polysaccharide monooxygenase (LPMO) and xylanase

(2018) Jinguang Hu et al.   Scientific Reports

Comparing Microbiome Sampling Methods in a Wild Mammal: Fecal and Intestinal Samples Record Different Signals of Host Ecology, Evolution

(2018) Melissa R. Ingala et al.   Frontiers in Microbiology

The Pyrroloquinoline-Quinone-Dependent Pyranose Dehydrogenase from Coprinopsis cinerea Drives Lytic Polysaccharide Monooxygenase Action

(2018) Anikó Várnai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A colorimetric assay to rapidly determine the activities of lytic polysaccharide monooxygenases

(2018) Damao Wang et al.   Biotechnology for Biofuels

The impact of hydrogen peroxide supply on LPMO activity and overall saccharification efficiency of a commercial cellulase cocktail

(2018) Gerdt Müller et al.   Biotechnology for Biofuels

Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

(2017) Alda Lisa Concia et al.   INORGANIC CHEMISTRY

Catalytic Mechanism of Fungal Lytic Polysaccharide Monooxygenases Investigated by First-Principles Calculations

(2017) Luca Bertini et al.   INORGANIC CHEMISTRY

Structural determinants of bacterial lytic polysaccharide monooxygenase functionality

(2017) Zarah Forsberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution structure of a lytic polysaccharide monooxygenase fromHypocrea jecorinareveals a predicted linker as an integral part of the catalytic domain

(2017) Henrik Hansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active-site copper reduction promotes substrate binding of fungal lytic polysaccharide monooxygenase and reduces stability

(2017) Daniel Kracher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of H2O2-driven degradation of chitin by a bacterial lytic polysaccharide monooxygenase

(2017) Silja Kuusk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formally Copper(III)–Alkylperoxo Complexes as Models of Possible Intermediates in Monooxygenase Enzymes

(2017) Benjamin D. Neisen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate and Lewis Acid Coordination Promote O–O Bond Cleavage of an Unreactive L2CuII2(O22–) Species to Form L2CuIII2(O)2 Cores with Enhanced Oxidative Reactivity

(2017) Isaac Garcia-Bosch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Physiological and Molecular Understanding of Bacterial Polysaccharide Monooxygenases

(2017) Marco Agostoni et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Oxidative cleavage of polysaccharides by monocopper enzymes depends on H2O2

(2017) Bastien Bissaro et al.   Nature Chemical Biology

Disulfide bridges as essential elements for the thermostability of lytic polysaccharide monooxygenase LPMO10C from Streptomyces coelicolor

(2017) Magali Tanghe et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Copper-Catalyzed Oxidation of Alkanes under Mild Conditions

(2017) Isaac Garcia-Bosch   SYNLETT

Single-molecule study of oxidative enzymatic deconstruction of cellulose

(2017) Manuel Eibinger et al.   Nature Communications

Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates

(2017) T. J. Simmons et al.   Nature Communications

Lytic polysaccharide monooxygenases disrupt the cellulose fibers structure

(2017) Ana Villares et al.   Scientific Reports

Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder

(2017) Kristian E. H. Frandsen et al.   Acta Crystallographica Section D-Structural Biology

Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineeredPichia pastorisfor X-ray and neutron diffraction

(2017) William B. O'Dell et al.   Acta Crystallographica Section F-Structural Biology Communications

A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity

(2017) Barbara Danneels et al.   PLoS One

Biochemical studies of two lytic polysaccharide monooxygenases from the white-rot fungus Heterobasidion irregulare and their roles in lignocellulose degradation

(2017) Bing Liu et al.   PLoS One

Action of lytic polysaccharide monooxygenase on plant tissue is governed by cellular type

(2017) Brigitte Chabbert et al.   Scientific Reports

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

(2016) William B. O'Dell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neutron protein crystallography: A complementary tool for locating hydrogens in proteins

(2016) William B. O'Dell et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

On the catalytic mechanisms of lytic polysaccharide monooxygenases

(2016) Paul H Walton et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Activity, stability and 3-D structure of the Cu(ii) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens

(2016) Rebecca C. Gregory et al.   DALTON TRANSACTIONS

The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases

(2016) Lucy I. Crouch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases

(2016) Kristian E H Frandsen et al.   Nature Chemical Biology

Interactions of a fungal lytic polysaccharide monooxygenase with β-glucan substrates and cellobiose dehydrogenase

(2016) Gaston Courtade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of bacterial lytic polysaccharide monooxygenases with cellobiose dehydrogenase

(2016) Jennifer S. M. Loose et al.   PROTEIN SCIENCE

Extracellular electron transfer systems fuel cellulose oxidative degradation

(2016) D. Kracher et al.   SCIENCE

Lytic Polysaccharide Monooxygenases: The Microbial Power Tool for Lignocellulose Degradation

(2016) Katja Salomon Johansen   TRENDS IN PLANT SCIENCE

Light-driven oxidation of polysaccharides by photosynthetic pigments and a metalloenzyme

(2016) D. Cannella et al.   Nature Communications

Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

(2016) Kristian E. H. Frandsen et al.   IUCrJ

Harnessing the potential of LPMO-containing cellulase cocktails poses new demands on processing conditions

(2015) Gerdt Müller et al.   Biotechnology for Biofuels

Substrate specificity and regioselectivity of fungal AA9 lytic polysaccharide monooxygenases secreted by Podospora anserina

(2015) Chloé Bennati-Granier et al.   Biotechnology for Biofuels

Catalase improves saccharification of lignocellulose by reducing lytic polysaccharide monooxygenase-associated enzyme inactivation

(2015) Brian R. Scott et al.   BIOTECHNOLOGY LETTERS

Elaboration of copper–oxygen mediated C–H activation chemistry in consideration of future fuel and feedstock generation

(2015) Jung Yoon Lee et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural and Functional Characterization of a Lytic Polysaccharide Monooxygenase with Broad Substrate Specificity

(2015) Anna S. Borisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

(2015) Annegret Kohler et al.   NATURE GENETICS

Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors

(2015) Firoz Shah et al.   NEW PHYTOLOGIST

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

(2015) Leila Lo Leggio et al.   Nature Communications

Structural and Electronic Snapshots during the Transition from a Cu(II) to Cu(I) Metal Center of a Lytic Polysaccharide Monooxygenase by X-ray Photoreduction

(2014) Mikael Gudmundsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellulose Surface Degradation by a Lytic Polysaccharide Monooxygenase and Its Effect on Cellulase Hydrolytic Efficiency

(2014) Manuel Eibinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spectroscopic and computational insight into the activation of O2 by the mononuclear Cu center in polysaccharide monooxygenases

(2014) C. H. Kjaergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A family of starch-active polysaccharide monooxygenases

(2014) V. V. Vu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases

(2014) Z. Forsberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation

(2014) J. W. Agger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes

(2013) Anthony Levasseur et al.   Biotechnology for Biofuels

A C4-oxidizing Lytic Polysaccharide Monooxygenase Cleaving Both Cellulose and Cello-oligosaccharides

(2013) Trine Isaksen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces

(2013) Taichi E. Takasuka et al.   Scientific Reports

Production of four Neurospora crassa lytic polysaccharide monooxygenases in Pichia pastoris monitored by a fluorimetric assay

(2012) Roman Kittl et al.   Biotechnology for Biofuels

The ectomycorrhizal fungus Paxillus involutus converts organic matter in plant litter using a trimmed brown-rot mechanism involving Fenton chemistry

(2012) Francois Rineau et al.   ENVIRONMENTAL MICROBIOLOGY

Wood Utilization Is Dependent on Catalase Activities in the Filamentous Fungus Podospora anserina

(2012) Anne Bourdais et al.   PLoS One

NMR structure of a lytic polysaccharide monooxygenase provides insight into copper binding, protein dynamics, and substrate interactions

(2012) F. L. Aachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins

(2012) E. A. Znameroski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellulose-degrading bacteria associated with the invasive woodwasp Sirex noctilio

(2011) Aaron S Adams et al.   ISME Journal

Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components

(2011) R. J. Quinlan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of Lignocellulosic Biomass Hydrolysis by Proteins of Glycoside Hydrolase Family 61: Structure and Function of a Large, Enigmatic Family

(2010) Paul V. Harris et al.   BIOCHEMISTRY

An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides

(2010) Gustav Vaaje-Kolstad et al.   SCIENCE