Article
Developmental Biology
Hui Li, Liping Zhou, Ce Zhang, Qi Xi, Jinghuan Lv, Weiwei Huo, Liping Zhu, Rui Zhu, Yue Zhang
Summary: This study found that the deficiency of FST impairs trophoblast function by upregulating the levels of GDF11, leading to the development of preeclampsia. The high expression of miR-24-3p in preeclamptic placentas may be an important factor in this mechanism.
Article
Environmental Sciences
Ying Zhao, Huanqiang Zhao, Huangfang Xu, Ping Hu, Bo Ma, Huiqing Lu, Qiongjie Zhou, Xiaotian Li, Yu Xiong
Summary: This study established an animal model of PFOS-induced preeclampsia and explored the molecular mechanism of PFOS in placental trophoblast. The results suggest that PFOS exposure may cause preeclampsia by impairing trophoblast mitochondria.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yue Liang, Ping Wang, Yueyang Shi, Bihong Cui, Jinlai Meng
Summary: This study revealed that MEG3 regulates trophoblast function and inflammation through the Wnt/beta-Catenin/NLRP3 axis, providing new insights into the pathogenesis of preeclampsia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Biotechnology & Applied Microbiology
Xia Zhang, Xiufeng Zhang
Summary: The level of miR-135b-5p is lower in patients with preeclampsia (PE) superimposed on chronic hypertension than in healthy controls. In this study, we investigated the role of miR-135b-5p in the development of preeclampsia and its mechanism of regulating trophoblast cell function by targeting PIK3R2.
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Han Gong, Fan Lu, Xiaoling Zeng, Qing Bai
Summary: Preeclampsia (PE) is a serious pregnancy syndrome caused by attenuated trophoblast proliferation and invasion. E2F1 and ZEB1 play important roles in PE by promoting trophoblast proliferation, invasiveness, and epithelial-mesenchymal transition (EMT).
Review
Cell Biology
Shifeng Tian, Xiaoyi Xu, Xiaohui Yang, Linlin Fan, Yuqi Jiao, Minying Zheng, Shiwu Zhang
Summary: This review summarizes the pathophysiological roles of FSTL3 and discusses its potential as a prognostic biomarker and therapeutic target for various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Bian, Jiapo Li, Hongfei Shen, Yuanyuan Li, Yue Hou, Ling Huang, Guiyu Song, Chong Qiao
Summary: This study found that the level of N6-methyladenosine (m6A) in placental tissue of early-onset preeclampsia (ePE) patients was reduced. Wilms' tumor 1-associating protein (WTAP), a regulator of m6A, was found to regulate trophoblast cell migration and invasion. The study also revealed the interaction between WTAP and the high mobility group nucleosomal binding domain 3 (HMGN3) gene, and the effect of m6A on the stability of HMGN3 mRNA. WTAP enhanced the stability of HMGN3 mRNA by binding to its m6A site, and HMGN3 was recognized and regulated by insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). The results suggest that m6A modification plays an important role in the pathogenesis of ePE.
Article
Cell Biology
Yan Li, Xian-li Sun, Chun-ling Ma, Chao Li, Ying Zhan, Wen-ting Li, Can Li, Yi-hao Wang
Summary: Abnormal trophoblast behaviors during pregnancy contribute to the development of preeclampsia (PE), with Syntaxin2 (STX2) identified as a crucial epithelial mediator in various diseases. This study aimed to explore the role of STX2 in trophoblast biology and unravel the molecular mechanisms underlying its involvement in PE. Results showed that STX2 expression was downregulated in placental tissues from women with PE compared to normal pregnancies, and further experiments revealed its interaction with the PI3K subunit p85, activating the AKT signaling pathway. These findings indicate a potential diagnostic tool and therapeutic target for treating PE.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nan Chu, Yao Tang, Cheng-Jie Wang, Jiang-Nan Pei, Shou-Ling Luo, Yi Yu, Zhen-Zhen Liu, Hai-Yan Liu, Xue-Min Qiu, Ling Wang, Da-Jin Li, Wei-Rong Gu
Summary: Preeclampsia is associated with a lack of active ANP, and ANP can promote trophoblast invasion by inhibiting autophagy. The study also found that NFYA is one of the transcription factors for PKN3 and ANP can regulate PKN3 expression through NFYA. These findings suggest that ANP can enhance trophoblast invasion by inhibiting autophagy through the AMPK/mTORC1 signaling pathway.
Article
Biotechnology & Applied Microbiology
Yang Yang, Xiaoxia Qiu, Fang Wang
Summary: The study found that downregulation of PTPRO significantly promoted the proliferation and invasion of trophoblast cells, inducing stronger in vitro angiogenesis, while overexpression of ERp44 suppressed these activities. There is an interaction between ERp44 and PTPRO, which affects the biological behaviors of trophoblast cells by modulating ERp44.
Article
Medicine, General & Internal
Jianye Deng, Hong-Jin Zhao, Ying Zhong, Cuiping Hu, Jinlai Meng, Chunling Wang, Xiangxin Lan, Xiyao Wang, Zi-Jiang Chen, Junhao Yan, Wei Wang, Yan Li
Summary: This study found that the enhanced bone morphogenetic protein 2 (BMP2) signaling derived from placenta in late gestation is associated with compensatory response for shallow trophoblast invasion in preeclampsia (PE). These findings provide opportunities for the application of diagnostic markers and therapeutic targets in the management of PE.
Article
Cell Biology
Huan Yang, Xuemei Zhang, Yubin Ding, Hui Xiong, Shaojian Xiang, Yang Wang, Huanhuan Li, Zheng Liu, Jie He, Yuelan Tao, Hongbing Yang, Hongbo Qi
Summary: This study reveals an increase in ferroptosis and a downregulation of Elabela expression in preeclampsia placentas. A mouse model of preeclampsia-like features confirms the presence of a ferroptosis phenotype in the placenta, and Elabela can reduce ferroptosis and improve adverse pregnancy outcomes. Mechanistic studies suggest that Elabela inhibits the ferritinophagy pathway to increase FTH1 levels, chelate intracellular labile iron, and arrest ferroptosis. In conclusion, targeting the Elabela-ferritinophagy-ferroptosis signaling axis provides a new therapeutic intervention strategy for alleviating preeclampsia.
Article
Geriatrics & Gerontology
Jorge R. Kizer, Sheena Patel, Peter Ganz, Anne B. Newman, Shalender Bhasin, Se-Jin Lee, Peggy M. Cawthon, Nathan K. LeBrasseur, Sanjiv J. Shah, Bruce M. Psaty, Russell P. Tracy, Steven R. Cummings
Summary: This study suggests that serum follistatin and FSTL-3, but not GDF-11 or GDF-8, are associated with incident heart failure in older adults, implicating transforming growth factor-beta superfamily pathways as potential therapeutic targets.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)