Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes
Authors
Keywords
-
Journal
ARCHIVES OF TOXICOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Nature America, Inc
Online
2018-11-14
DOI
10.1007/s00204-018-2349-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions
- (2018) Sabine U Vorrink et al. TOXICOLOGICAL SCIENCES
- Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
- (2016) María José Gómez-Lechón et al. ARCHIVES OF TOXICOLOGY
- Current limitations and future opportunities for prediction of DILI from in vitro
- (2016) Christoph Funk et al. ARCHIVES OF TOXICOLOGY
- Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells
- (2016) Amy L. Ball et al. TOXICOLOGICAL SCIENCES
- Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
- (2016) Laia Tolosa et al. TOXICOLOGICAL SCIENCES
- Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
- (2016) Laia Tolosa et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Drug-induced liver injury: an overview over the most critical compounds
- (2015) Einar S. Björnsson ARCHIVES OF TOXICOLOGY
- Metabolic activation and drug-induced liver injury:in vitroapproaches for the safety risk assessment of new drugs
- (2015) M. José Gómez-Lechón et al. JOURNAL OF APPLIED TOXICOLOGY
- Long-term culture and expansion of primary human hepatocytes
- (2015) Gahl Levy et al. NATURE BIOTECHNOLOGY
- Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
- (2015) Rowena L. C. Sison-Young et al. TOXICOLOGICAL SCIENCES
- In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments
- (2015) Giuliana Pomponio et al. TOXICOLOGY IN VITRO
- Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment
- (2015) Davide Germano et al. TOXICOLOGY IN VITRO
- Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure
- (2015) Jessica J.W. Broeders et al. TOXICOLOGY IN VITRO
- Biokinetics in repeated-dosing in vitro drug toxicity studies
- (2015) Nynke I. Kramer et al. TOXICOLOGY IN VITRO
- Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems
- (2015) Germaine L. Truisi et al. TOXICOLOGY LETTERS
- Sex Differences in Liver Toxicity—Do Female and Male Human Primary Hepatocytes React Differently to Toxicants In Vitro?
- (2015) Milena Mennecozzi et al. PLoS One
- High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
- (2014) Laia Tolosa et al. ARCHIVES OF TOXICOLOGY
- Competency of different cell models to predict human hepatotoxic drugs
- (2014) M José Gómez-Lechón et al. Expert Opinion on Drug Metabolism & Toxicology
- Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes
- (2013) Stephanie L. MacAllister et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Optimization of upcyte® human hepatocytes for the in vitro micronucleus assay
- (2013) Astrid Nörenberg et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Valproic acid pathway
- (2013) Yogita Ghodke-Puranik et al. Pharmacogenetics and Genomics
- A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
- (2013) Radina Kostadinova et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
- (2013) Daniel Mueller et al. TOXICOLOGY IN VITRO
- Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
- (2012) Laia Tolosa et al. TOXICOLOGICAL SCIENCES
- Generation of proliferating human hepatocytes using upcyte®technology: characterisation and applications in induction and cytotoxicity assays
- (2012) Alexandra Burkard et al. XENOBIOTICA
- Towards an integrated in vitro strategy for repeated dose toxicity testing
- (2011) Tamara Vanhaecke et al. ARCHIVES OF TOXICOLOGY
- Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells
- (2011) Sébastien Anthérieu et al. HEPATOLOGY
- Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—A comparison with other phenothiazines
- (2010) Jacek Wójcikowski et al. BIOCHEMICAL PHARMACOLOGY
- Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study
- (2010) Adrian Reuben et al. HEPATOLOGY
- Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
- (2009) Rohini Kashimshetty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Bioactivation of Flutamide Metabolites by Human Liver Microsomes
- (2008) P. Kang et al. DRUG METABOLISM AND DISPOSITION
- Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies
- (2008) R. Josse et al. DRUG METABOLISM AND DISPOSITION
- Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review
- (2008) M. F. B. Silva et al. JOURNAL OF INHERITED METABOLIC DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now