Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype

New mechanistic insights on the metabolic-disruptor role of chlorpyrifos in apoE mice: a focus on insulin- and leptin-signalling pathways

(2018) Fiona Peris-Sampedro et al.   ARCHIVES OF TOXICOLOGY

Postnatal chlorpyrifos exposure and apolipoprotein E (APOE) genotype differentially affect cholinergic expression and developmental parameters in transgenic mice

(2018) Pia Basaure et al.   FOOD AND CHEMICAL TOXICOLOGY

Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner

(2018) Laia Guardia-Escote et al.   FOOD AND CHEMICAL TOXICOLOGY

Accelerated Progression from Mild Cognitive Impairment to Dementia Among APOE ε4ε4 Carriers

(2018) Wei-Li Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Developmental neurotoxicity of succeeding generations of insecticides

(2017) Yael Abreu-Villaça et al.   ENVIRONMENT INTERNATIONAL

APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review

(2016) Diego A. Forero et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Organophosphate pesticide exposure and neurodegeneration

(2016) Fernando Sánchez-Santed et al.   CORTEX

Apolipoprotein E (APOE) genotype and the pesticide chlorpyrifos modulate attention, motivation and impulsivity in female mice in the 5-choice serial reaction time task

(2016) Fiona Peris-Sampedro et al.   FOOD AND CHEMICAL TOXICOLOGY

APOE -Sensitive Cholinergic Sprouting Compensates for Hippocampal Dysfunctions Due to Reduced Entorhinal Input

(2016) Jean-Bastien Bott et al.   JOURNAL OF NEUROSCIENCE

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation

(2016) Qi Yao et al.   Scientific Reports

Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice

(2015) Fiona Peris-Sampedro et al.   ENVIRONMENTAL RESEARCH

mRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance

(2015) Beatriz E. García-Gómez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice

(2015) Eva Dolejší et al.   JOURNAL OF NEUROCHEMISTRY

Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model

(2015) Fiona Peris-Sampedro et al.   PHYSIOLOGY & BEHAVIOR

APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults

(2015) J. P. Shine et al.   Scientific Reports

Strain dependent effects of conditioned fear in adult C57Bl/6 and Balb/C mice following postnatal exposure to chlorpyrifos: relation to expression of brain acetylcholinesterase mRNA

(2015) Sarit Oriel et al.   Frontiers in Behavioral Neuroscience

Impaired retention in AβPP Swedish mice six months after oral exposure to chlorpyrifos

(2014) Fiona Peris-Sampedro et al.   FOOD AND CHEMICAL TOXICOLOGY

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

Thyroid hormones and fear learning but not anxiety are affected in adult apoE transgenic mice exposed postnatally to decabromodiphenyl ether (BDE-209)

(2014) Ingrid Reverte et al.   PHYSIOLOGY & BEHAVIOR

The potential applications of Apolipoprotein E in personalized medicine

(2014) Sylvia Villeneuve et al.   Frontiers in Aging Neuroscience

Higher Rates of Decline for Women andApolipoprotein Eε4 Carriers

(2013) D. Holland et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status

(2013) Simon Evans et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

(2013) G. A. Rodriguez et al.   LEARNING & MEMORY

Comparative study on short- and long-term behavioral consequences of organophosphate exposure: Relationship to AChE mRNA expression

(2013) Caridad López-Granero et al.   NEUROTOXICOLOGY

Long term effects of murine postnatal exposure to decabromodiphenyl ether (BDE-209) on learning and memory are dependent upon APOE polymorphism and age

(2013) Ingrid Reverte et al.   NEUROTOXICOLOGY AND TERATOLOGY

ApoE4 Induces Synaptic and ERG Impairments in the Retina of Young Targeted Replacement ApoE4 Mice

(2013) Ran Antes et al.   PLoS One

Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA

(2013) Caridad López-Granero et al.   TOXICOLOGY

Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

(2012) Ingrid Reverte et al.   EXPERIMENTAL NEUROLOGY

Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning

(2012) Sarah Ruediger et al.   NATURE NEUROSCIENCE

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

(2012) Ana M. Sebastião et al.   NEUROPHARMACOLOGY

Repeated exposures to chlorpyrifos lead to spatial memory retrieval impairment and motor activity alteration

(2012) Changhui Yan et al.   NEUROTOXICOLOGY AND TERATOLOGY

Chlorpyrifos-, Diisopropylphosphorofluoridate-, and Parathion-Induced Behavioral and Oxidative Stress Effects: Are They Mediated by Analogous Mechanisms of Action?

(2012) Caridad López-Granero et al.   TOXICOLOGICAL SCIENCES

Amyloid β Peptide Levels Increase in Brain of AβPP Swedish Mice after Exposure to Chlorpyrifos

(2011) Jose G. Salazar et al.   Current Alzheimer Research

Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells

(2011) Gadi Turgeman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain

(2011) A. Dori et al.   NEUROSCIENCE

Chronic impairments in spatial learning and memory in rats previously exposed to chlorpyrfos or diisopropylfluorophosphate

(2011) A.V. Terry et al.   NEUROTOXICOLOGY AND TERATOLOGY

The cholinergic system and spatial learning

(2010) Serena Deiana et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Dramatic increase in readthrough acetylcholinesterase in a cellular model of oxidative stress

(2010) Ricarda Härtl et al.   JOURNAL OF NEUROCHEMISTRY

Asymmetric regulation by estrogen at the cholinergic gene locus in differentiated NG108-15 neuronal cells

(2010) Yutaka Yamamuro et al.   LIFE SCIENCES

Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

(2010) Kelly R. Bales   NEUROPHARMACOLOGY

Positive Effects of Cholinergic Stimulation Favor Young APOE ɛ4 Carriers

(2010) Natalie L Marchant et al.   NEUROPSYCHOPHARMACOLOGY

The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis

(2009) Nick M. Wisdom et al.   NEUROBIOLOGY OF AGING

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Developmental Chlorpyrifos and Methyl Parathion Exposure Alters Radial-Arm Maze Performance in Juvenile and Adult Rats

(2009) Frank O. Johnson et al.   TOXICOLOGICAL SCIENCES