Multifaceted C-terminus of HSP70-interacting protein regulates tumorigenesis via protein quality control

Post-translational modification of OCT4 in breast cancer tumorigenesis

(2018) Yunhee Cho et al.   CELL DEATH AND DIFFERENTIATION

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death

(2018) Jinho Seo et al.   ONCOGENE

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

Reciprocal regulations between miRNAs and HIF-1α in human cancers

(2018) Wanli Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance

(2017) Kuntal Biswas et al.   MOLECULAR CANCER RESEARCH

Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP

(2017) Sukumar Sarkar et al.   MOLECULAR CANCER RESEARCH

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

(2017) Y Shang et al.   ONCOGENE

The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation

(2016) Chaeuk Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF

(2016) Su Yeon Han et al.   CANCER RESEARCH

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

PARP1 regulates the protein stability and proapoptotic function of HIPK2

(2016) Jong-Ryoul Choi et al.   Cell Death & Disease

Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

(2016) Lei Wang et al.   Scientific Reports

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells

(2015) Maeva Dufies et al.   Oncotarget

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3

(2014) Natalya A. Blessing et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation accelerates geldanamycin-induced Akt degradation

(2013) Chih-Hao Su et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation

(2013) Gnana Prakasam Krishnamoorthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP protects against cardiac pressure overload through regulation of AMPK

(2013) Jonathan C. Schisler et al.   JOURNAL OF CLINICAL INVESTIGATION

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK3β controls epithelial–mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug

(2013) S-H Kao et al.   ONCOGENE

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

(2012) Shin-Ae Kang et al.   BIOCHEMICAL JOURNAL

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Activation of TYRO3/AXL Tyrosine Kinase Receptors in Thyroid Cancer

(2011) E. Avilla et al.   CANCER RESEARCH

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

(2011) K H Oh et al.   CELL DEATH AND DIFFERENTIATION

Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)

(2011) Le Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients

(2011) Chia-Ing Jan et al.   JOURNAL OF PATHOLOGY

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

(2011) H Gaude et al.   ONCOGENE

Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-α induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1

(2010) Yanhong Gao et al.   APOPTOSIS

AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

(2010) E. B. Rankin et al.   CANCER RESEARCH

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

(2010) Atsuhiko T. Naito et al.   CIRCULATION RESEARCH

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

(2010) Takeshi Maruyama et al.   EMBO JOURNAL

CHIP-dependent p53 regulation occurs specifically during cellular senescence

(2010) Christina Sisoula et al.   FREE RADICAL BIOLOGY AND MEDICINE

PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1

(2010) Shin-Ae Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity

(2010) Ji Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

(2010) R Puca et al.   ONCOGENE

CHIP functions an E3 ubiquitin ligase of Runx1

(2009) Yu Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1

(2009) Fang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP

(2009) Lenka Kundrat et al.   JOURNAL OF MOLECULAR BIOLOGY

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

(2008) Chih-Chen Hong et al.   CANCER LETTERS

Down-regulation of Mammalian Sterile 20-Like Kinase 1 by Heat Shock Protein 70 Mediates Cisplatin Resistance in Prostate Cancer Cells

(2008) A. Ren et al.   CANCER RESEARCH

AXL Is a Potential Target for Therapeutic Intervention in Breast Cancer Progression

(2008) Y.-X. Zhang et al.   CANCER RESEARCH

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE