Review
Biochemistry & Molecular Biology
Steven O'Reilly
Summary: Gremlin-1, part of the TGF-beta superfamily, acts as a BMP antagonist involved in organ development and limb patterning, as well as being associated with various fibrotic diseases such as diabetic kidney fibrosis. Its effects seem to be mediated by both BMP-dependent and independent pathways, making it a potential therapeutic target for fibrotic diseases with limited treatment options.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa, Jorg H. W. Distler, Richard Stratton, Steven O'Reilly
Summary: The study revealed that overexpression of Gremlin-1 activates quiescent cells to myofibroblasts and leads to functional effects. Gremlin-1 induces this process by increasing TGF-beta 1 levels and SBE luciferase activity. Inhibition of Gremlin-1 reduces collagen levels, indicating its key role in systemic sclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biophysics
Aabha Bajaj, Mohammad Abutoama, Sivan Isaacs, Marwan J. Abuleil, Karin Yaniv, Ariel Kushmaro, Martina Modic, Uros Cvelbar, Ibrahim Abdulhalim
Summary: Unwelcomed biofilms are a problem in environments where moisture is present, such as food industries and wastewater treatment plants. Advanced label-free sensors like surface plasmon resonance (SPR) have been explored for monitoring biofilm formation, but conventional noble metal SPR substrates have limited penetration depth, hindering reliable detection. In this study, a plasmonic insulator-metal-insulator (IMI) structure with higher penetration depth was proposed for portable SPR devices. The optimized IMI structure showed strong penetration dependence on wavelength and incidence angle, providing more reliable results compared to thin gold film substrates. The methodology can detect and characterize biofilms with better signal reliability.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Suzuyo Inoue, Kenta Fukada, Katsuyoshi Hayashi, Michiko Seyama
Summary: This study developed a novel measuring and data-processing method for electrochemical surface plasmon resonance (EC-SPR), which can be used to detect sensor surfaces that are difficult to measure a specific SPR angle, especially for samples with non-uniform thickness and coloration like polymers. The proposed method combines SPR measurements with an electrochemical reaction to measure small molecules without increasing the number of measurement steps.
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Bluher, Ulf Smith
Summary: Hepatic cell senescence is a key factor in human NAFLD/NASH. BMP4 and Gremlin 1 are identified as novel therapeutic targets.
Article
Cell Biology
Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon, Hiromasa Hirai, Hongying Tian, Ivan Alferiev, Michael Chorny, Satoru Otsuru, Seiji Okada, Masahiro Iwamoto
Summary: BMPs have been used clinically for bone formation in musculoskeletal disorders, but high doses can lead to adverse events. A potent antagonist of RAR gamma was found to enhance BMP-induced bone formation, leading to increased bone volume and thickness, as well as promoting chondrogenic gene expression. This suggests potential for improving BMP-2 based bone regeneration procedures in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiaqi Guo, Xinyu Zhang, Jing Tian, Wenyuan Zhu, Junlong Song, Huining Xiao
Summary: In this study, the optical properties of ultrathin cellulose nanocrystal films deposited on gold surface of SPR sensors were determined using a two-medium SPR technique. The measured refractive index, porosity, and film thickness allowed for quality control of the modified SPR sensors before adsorption experiments. Overall, the results demonstrated the effectiveness of SPR surveys combined with Winspall analysis in determining the quality of ultrathin films on SPR sensors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Optics
Jingwen Feng, Jinjuan Gao, Wen Yang, Runcheng Liu, Muhammad Shafi, Zhipeng Zha, Cong Liu, Shicai Xu, Tingyin Ning, Shouzhen Jiang
Summary: This paper presents the fabrication of a D-shaped plastic optical fiber (D-POF) LSPR sensor based on a monolayer graphene/gold nanoparticles (Gr(m)/Au NPs) three-dimensional (3D) hybrid structure. The number of plasmonic structure layers was found to be important for sensor performance, with the optimal electromagnetic field enhancement effect observed in a three-layer plasmonic structure. The sensor exhibited outstanding sensitivity, linearity, and reproducibility, and successfully detected the concentration of glucose, suggesting promising applications in medicine and biotechnology.
Article
Polymer Science
Yi-Jung Lu, Han-Yun Hsieh, Wen-Chang Kuo, Pei-Kuen Wei, Horn-Jiunn Sheen, Hidetoshi Tahara, Te-Wei Chiu, Yu-Jui Fan
Summary: The study proposed a multiplex detection system by integrating LSPR sensing array and microfluidic channels, proving successful in detecting different targets in parallel channels.
Article
Materials Science, Multidisciplinary
Yury Zhidik, Anna Ivanova, Serafim Smirnov, Klavdiya Zhuk, Igor Yunusov, Pavel Troyan
Summary: The development of plasmonics has led to the possibility of high-speed and highly sensitive optical sensors for analyzing chemical and biological media. In this study, the researchers demonstrate that the use of indium tin oxide (ITO) films with a high concentration of charge carriers can shift the surface plasmon resonance into the visible radiation region. The results show that SPR can be excited in ITO films with a concentration of free charge carriers, and the excitation wavelength of SPR can be changed by adding various analytes.
Article
Engineering, Electrical & Electronic
Nancy Sidana, Prachi Rajput, Pooja Devi, Harminder Kaur
Summary: A highly sensitive and selective colorimetric sensor assay for detecting Hg2+ ions is presented in this study. This approach utilizes an anti-aggregation sensing method with AuNPs and an amine-based sensor (S) to achieve color variation from red to blue, indicating the presence of Hg2+ ions.
IEEE SENSORS JOURNAL
(2022)
Article
Biophysics
Richard B. M. Schasfoort, Jos van Weperen, Margot van Amsterdam, Judicael Parisot, Jan Hendriks, Michelle Koerselman, Marcel Karperien, Anouk Mentink, Martin Bennink, Hans Krabbe, Leon W. M. M. Terstappen, A. H. Leontine Mulder
Summary: The SPRi assay revealed that levels and binding strength of IgG antibodies against the RBD protein increased during the course of the disease in COVID-19 patients, while levels of IgM and IgA generally decreased. Recovered patients exhibited high binding strength of IgG antibodies to the RBD protein.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Inorganic & Nuclear
Abin Philip, A. Ruban Kumar
Summary: The necessity for the development of highly sensitive and selective detection techniques for the investigation of biomolecules is inevitable. Surface plasmon resonance (SPR) based biosensor has evolved as a sustainable and commercially applicable tool for this investigation. Exploring real-time, cost-effective, and time-efficient detection techniques is crucial for improving quality of life.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Yuzhan Zhang, Ke Li, Yan Li, Weihao Zhao, Li Wang, Zhao Chen, Xiaotao Ma, Tian Yao, Jinhua Wang, Wei Dong, Xiancheng Li, Xuefei Tian, Rongguo Fu
Summary: This study found increased expression of DPP8 and DPP9 in renal proximal tubule epithelial cells of CKD patients, and using a DPP8/DPP9 inhibitor significantly attenuated tubulointerstitial injury and improved renal function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Daoquan Liu, Jianmin Liu, Yan Li, Huan Liu, Hassan M. Hassan, Weixiang He, Mingzhou Li, Yongying Zhou, Xun Fu, Junfeng Zhan, Zhen Wang, Shu Yang, Ping Chen, Deqiang Xu, Xinhuan Wang, Michael E. DiSanto, Guang Zeng, Xinhua Zhang
Summary: The study found that BMP5 is upregulated in hyperplastic tissues in humans and rats, localized in both the epithelial and stromal compartments of the prostate tissues. Overexpression of BMP5 enhances cell proliferation and the EMT process through phosphorylation of Smad1/5/8, while knockdown of BMP5 induces cell cycle arrest at G0/G1 phase and blocks the EMT process. BMP5 expression is positively correlated with prostate volume and total prostate-specific antigen levels. The BMP/Smad signaling pathway may be a promising therapeutic target for BPH.
Article
Cardiac & Cardiovascular Systems
Emma Robinson, Roslyn S. Cassidy, Mitchel Tate, Youyou Zhao, Samuel Lockhart, Danielle Calderwood, Rachel Church, Mary K. McGahon, Derek P. Brazil, Barbara J. McDermott, Brian D. Green, David J. Grieve
BASIC RESEARCH IN CARDIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Beatriz Santamaria, Eva Marquez, Abigail Lay, RoseaMarie M. Carew, Agueda Gonzalez-Rodriguez, Gavin I. Welsh, Lan Ni, Lorna J. Hale, Alberto Ortiz, Moin A. Saleem, Derek P. Brazil, Richard J. Coward, Angela M. Valverde
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Editorial Material
Genetics & Heredity
Derek P. Brazil
JOURNAL OF MOLECULAR MEDICINE-JMM
(2015)
Review
Endocrinology & Metabolism
Deborah P. Lavin, Morris F. White, Derek P. Brazil
Article
Cell & Tissue Engineering
Michelle B. Hookham, Imran H. A. Ali, Christina L. O'Neill, Emer Hackett, Melanie H. Lambe, Tina Schmidt, Reinhold J. Medina, Sara Chamney, Bharathi Rao, Eibhlin McLoone, David Sweet, Alan W. Stitt, Derek P. Brazil
STEM CELL RESEARCH & THERAPY
(2016)
Article
Oncology
Hyunji Lee, Jisoo Park, Quangdon Tran, Dohoon Kim, Youngeun Hong, Hyeonjeong Cho, So Hee Kwon, Derek Brazil, Seon-Hwan Kim, Jongsun Park
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Hyunji Lee, Minhee Kim, Jisoo Park, Quangdon Tran, Youngeun Hong, Hyeonjeong Cho, Sungjin Park, Suntaek Hong, Derek P. Brazil, Seon-Hwan Kim, Jongsun Park
MOLECULAR MEDICINE REPORTS
(2018)
Article
Ophthalmology
Olivia E. O'Leary, Paul Canning, Emma Reid, Pietro M. Bertelli, Stuart McKeown, Michael Brines, Anthony Cerami, Xuan Du, Heping Xu, Mei Chen, Louise Dutton, Derek P. Brazil, Reinhold J. Medina, Alan W. Stitt
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Louise R. Dutton, Christina L. O'Neill, Reinhold J. Medina, Derek P. Brazil
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Sadaf Ashraf, Samuel Bell, Caitriona O'Leary, Paul Canning, Ileana Micu, Jose A. Fernandez, Michael O'Hare, Peter Barabas, Hannah McCauley, Derek P. Brazil, Alan W. Stitt, J. Graham McGeown, Tim M. Curtis
Article
Toxicology
Jisoo Park, Hyunji Lee, Quangdon Tran, Kisun Mun, Dohoon Kim, Youngeun Hong, So Hee Kwon, Derek Brazil, Jongsun Park, Seon-Hwan Kim
TOXICOLOGICAL RESEARCH
(2017)
Review
Cardiac & Cardiovascular Systems
Corey Magee, David J. Grieve, Chris J. Watson, Derek P. Brazil
CARDIOVASCULAR DRUGS AND THERAPY
(2017)
Article
Physiology
Rachel H. Church, Imran Ali, Mitchel Tate, Deborah Lavin, Arjun Krishnakumar, Helena M. Kok, Jose R. Hombrebueno, Philip D. Dunne, Victoria Bingham, Roel Goldschmeding, Finian Martin, Derek P. Brazil
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)