Review
Immunology
Shahnawaz D. Jadeja, Desmond J. Tobin
Summary: Alopecia areata is a chronic disorder that causes unpredictable non-scarring hair loss. The exact factors that cause this disease in the hair follicles remain unclear, but changes in immune-competence and immune response to hair follicle-associated antigens are important factors. The identification of the hair follicle antigen(s) responsible for AA onset is challenging but essential for understanding the disease and developing effective treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mei-Ling Yang, Fernanda M. C. Sodre, Mark J. Mamula, Lut Overbergh
Summary: The generation of post-translational modifications in human proteins is a crucial physiological process that can affect protein structure and function, leading to autoimmune responses and playing a role in many autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer
Summary: This study found that severe eosinophilic asthma (SEA) patients have ANCA-positive IgG antibodies against neutrophils, suggesting a potential autoimmune etiology. ELISA results showed significantly higher concentrations of autoantibodies to Collagen-V, MPO, and TREM1 in SEA patients compared to healthy controls. These findings suggest that autoantibody serology research may improve diagnostic testing for severe asthma.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Claire Deligne, Sylvaine You, Roberto Mallone
Summary: Our understanding of the immunopathological features of type 1 diabetes has improved, and personalized treatment based on disease stage and patient characteristics could enhance therapeutic efficacy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Endocrinology & Metabolism
Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Hongjun Wang, Yong Zhao
Summary: This review summarizes the current research progress of stem cell-derived extracellular vesicles (EVs) for the treatment of type 1 diabetes (T1D), suggesting their potential as novel therapeutic agents for autoimmune diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Sejal Mistry, Ramkiran Gouripeddi, Julio C. Facelli
Summary: We developed an in-silico pipeline to evaluate molecular mimicry in the etiology of type 1 diabetes, and identified potential high-impact molecular mimics. These findings provide valuable insights for further research and prevention efforts related to type 1 diabetes.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Teresa Rodriguez-Calvo, James D. Johnson, Lut Overbergh, Jessica L. Dunne
Summary: The pathogenesis of type 1 diabetes remains largely unknown, with questions surrounding the role of neoantigens, antigenic responses, and the mechanisms underlying tolerance breakdown. Further research into the timing and nature of antigenic responses could improve biomarker accuracy and provide potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Diana Valeria Rossetti, Alexandra Muntiu, Luca Massimi, Gianpiero Tamburrini, Claudia Desiderio
Summary: This review provides an overview of the current research on citrullination post-translational modification in adult and pediatric brain tumors. The role of citrullination in cancer and its potential as a target for therapy and diagnostic biomarkers are discussed.
Review
Biochemistry & Molecular Biology
Isabel Haro, Raimon Sanmarti, Maria J. Gomara
Summary: The review focuses on the role of post-translational modifications (PTMs) in autoimmune responses related to rheumatic diseases, particularly rheumatoid arthritis (RA). PTMs, such as citrullination, homocitrullination, and acetylation, lead to the generation of specific antibodies that have been implicated in the etiology, diagnosis, and prognosis of RA. Synthetic peptides modified with post-translational modifications are discussed as a means of detecting these autoantibodies in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Dongze Li, Li Zhang, Yanqiu He, Tingting Zhou, Xi Cheng, Wei Huang, Yong Xu
Summary: Diabetes is a prevalent global epidemic disease that is influenced by genetic, environmental, and socioeconomic factors. Histone post-translational modifications, specifically methylation and acetylation, play significant roles in the pathophysiological changes associated with diabetes. Recent advancements in mass spectrometry have identified novel histone acylation modifications, which are yet to be thoroughly investigated for their connection to diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Lorena Rodriguez-Martinez, Cristina Regueiro, Samer Amhaz-Escanlar, Carmen Pena, Paloma Herbello-Hermelo, Antonio Moreda-Pineiro, Javier Rodriguez-Garcia, Antonio Mera-Varela, Eva Perez-Pampin, Antonio Gonzalez
Summary: This study analyzed the autoantibody response of rheumatoid arthritis (RA) patients to four specific protein modifications. However, except for glycated collagen II, the other three modifications did not induce significant autoantibody response. Therefore, the repertoire of specific modified autoantigens in RA patients is limited.
Review
Immunology
Abu Saleh Md Moin, Manjula Nandakumar, Abdoulaye Diane, Mohammed Dehbi, Alexandra E. Butler
Summary: Type 1 diabetes is a T-cell mediated autoimmune disease characterized by the recognition of pancreatic beta-cell proteins as self-antigens, leading to their loss. Heat shock proteins play diverse roles in cellular functions, protecting cells from stress and potentially impacting the pathology of diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zachary J. J. Morse, Rachel L. L. Simister, Sean A. A. Crowe, Marc S. S. Horwitz, Lisa C. C. Osborne
Summary: Autoimmune disorders are complex diseases whose etiology is unclear. Evidence suggests that genetic susceptibility and environmental factors play a critical role. In type 1 diabetes (T1D), enterovirus infection and disruption of the intestinal microbiota have been independently associated with T1D onset. However, the interaction between viral infection and the intestinal microbiota remains unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mei-Ling Yang, Alaric J. P. Gee, Renelle J. Gee, Cecilia I. Zurita-Lopez, Shilpi Khare, Steven G. Clarke, Mark J. Mamula
Review
Immunology
Hester A. Doyle, Mei-Ling Yang, Maurice T. Raycroft, Renelle J. Gee, Mark J. Mamula
Article
Endocrinology & Metabolism
Mijke Buitinga, Aisha Callebaut, Fernanda Marques Camara Sodre, Inne Crevecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marre, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Review
Immunology
Mei-Ling Yang, Fernanda M. C. Sodre, Mark J. Mamula, Lut Overbergh
Summary: The generation of post-translational modifications in human proteins is a crucial physiological process that can affect protein structure and function, leading to autoimmune responses and playing a role in many autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mei-Ling Yang, Sheryl Horstman, Renelle Gee, Perrin Guyer, TuKiet T. Lam, Jean Kanyo, Ana L. Perdigoto, Cate Speake, Carla J. Greenbaum, Lut Overbergh, Richard G. Kibbey, Kevan C. Herold, Eddie A. James, Mark J. Mamula, Nisha Callebaut
Summary: This study implicates the citrullination of glucokinase in autoimmune diabetes inflammation, triggering autoimmunity and affecting glucokinase biological functions. The study also identifies glucokinase as a Type 1 diabetes biomarker, providing new insights into how inflammation drives post-translational modifications and affects beta cell metabolism.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Summary: In this study, the researchers found a group of carbonylated proteins in pancreatic islets before the onset of hyperglycemia in NOD mice. They discovered that carbonylated prolyl-4-hydroxylase beta subunit (P4Hb) is an autoantigen in both human and murine type 1 diabetes. They also found that carbonylated P4Hb is increased in stressed islets, leading to decreased insulin secretion and altered proinsulin-to-insulin ratios. Autoantibodies against P4Hb were detected in prediabetic NOD mice and early human type 1 diabetes patients. Additionally, the researchers identified autoreactive CD4(+) T-cell responses toward carbonyl-P4Hb epitopes in the circulation of patients with type 1 diabetes. These findings provide mechanistic insight into the pathways of proinsulin metabolism and the formation of autoantigens in type 1 diabetes.
Meeting Abstract
Immunology
Mei-Ling Yang, Li Wen, Kevan C. Herold, Mark J. Mamula
JOURNAL OF IMMUNOLOGY
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Mei-Ling Yang, Steven Clarke, Mark Mamula
Meeting Abstract
Immunology
Mei-Ling Yang, Sean Connolly, Li Wen, Kevan Herold, Mark Mamula
JOURNAL OF IMMUNOLOGY
(2013)
Meeting Abstract
Immunology
Mei-Ling Yang, Alaric Gee, Renelle Gee, Mark Mamula
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Mei-Ling Yang, Hester A. Doyle, Renelle J. Gee, Jonathan D. Lowenson, Steven Clarke, Brian R. Lawson, Dana W. Aswad, Mark J. Mamula
JOURNAL OF IMMUNOLOGY
(2006)
Meeting Abstract
Biochemistry & Molecular Biology
Mei-Ling Yang, Mark Mamula