Article
Chemistry, Multidisciplinary
Kween Saimuang, Khomson Suttisintong, Narongpol Kaewchangwat, Eknarin Thanayupong, Yodsathorn Wongngam, Putthiporn Charoenphun, Rujira Wanotayan, Abdelhamid Elaissari, Suradej Hongeng, Duangporn Polpanich, Kulachart Jangpatarapongsa
Summary: Iodine-131 meta-iodobenzylguanidine (I-131-mIBG) has been used in targeting therapies for neuroblastoma, with novel ligand-conjugated gold nanoparticles (GNPs) showing potential for enhancing treatment efficiency. Further investigation using animal models is planned to evaluate radiotherapeutic efficiency after I-131 substitution.
Article
Chemistry, Multidisciplinary
Shuxin Xu, Menghuan Zhao, Zikuan Gu, Haifeng Lu, Zhen Liu
Summary: This study reports the construction of polySia-targeting nanomissiles via molecular imprinting for the photothermal therapy of neuroblastoma. The nanomissiles specifically recognize polySia and target neuroblastoma cells with overexpressed polySia, showing promising potential for targeted therapy of neuroblastoma.
Article
Chemistry, Multidisciplinary
Xia Zhang, Like Ning, Hongshuai Wu, Suisui Yang, Ziyi Hu, Wenhong Wang, Yuandong Cao, Hongliang Xin, Chaoqun You, Fan Lin
Summary: The aim of this project is to investigate whether the cellulose-based hydrogel via in situ injection can serve as an alternative route for brain delivery of palbociclib (PB) and enhance its anti-glioblastoma (GBM) effect. The formed hydrogel (PB@PH/Cu-CNCs) demonstrated sustained drug retention and controlled release in vivo. Additionally, the PB-loaded hydrogel showed a more potent anti-GBM effect than free PB or drug-free hydrogel in both cultured cells and an orthotopic glioma model.
Article
Oncology
Stefano Giardino, Arnoldo Piccardo, Massimo Conte, Matteo Puntoni, Enrica Bertelli, Stefania Sorrentino, Mariapina Montera, Marco Risso, Ilaria Caviglia, Vania Altrinetti, Edoardo Lanino, Maura Faraci, Alberto Garaventa
Summary: The combination therapy of Th-I-131-MIBG and HD-BuMel has shown good efficacy in MIBG-avid NB patients, with reliable side effect control, but late complications may still occur.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
J. Van Heerden, M. Kruger, T. M. Esterhuizen, M. Hendricks, J. Du Plessis, G. Engelbrecht, M. Janse van Vuuren, B. van Emmenes, R. Uys, C. Burger, N. Nyakale, S. More, A. Brink
Summary: LDH, ferritin, and the diagnostic I-123-mIBG scans significantly predicted mCR, with only LDH predicting 2-year overall survival. Ferritin and the modified Curie scores correlated with each other, while MYCN amplification did not show significant correlations with the I-123-mIBG scans or survival rates.
Article
Clinical Neurology
Takayasu Mishima, Shinsuke Fujioka, Kenya Nishioka, Yuanzhe Li, Kazunori Sato, Hideki Houzen, Ichiro Yabe, Kazutaka Shiomi, Makoto Eriguchi, Hideo Hara, Nobutaka Hattori, Yoshio Tsuboi
Summary: The study identified novel mutations in the DCTN1 gene in patients with Perry disease, with most patients showing decreased cardiac uptake in MIBG myocardial scintigraphy and commonly presenting symptoms related to autonomic dysfunction. The findings suggest that MIBG myocardial scintigraphy may serve as a useful biomarker for autonomic dysfunction in Perry disease.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Medicine, Research & Experimental
Susanta Kumar Rout, Vishnu Priya, Aseem Setia, Abhishesh Kumar Mehata, Syam Mohan, Mohammed Albratty, Asim Najmi, Abdulkarim M. Meraya, Hafiz A. Makeen, Murtaza M. Tambuwala, Madaswamy S. Muthu
Summary: This article provides an in-depth analysis of cancer treatment targeting the mitochondrial genome at the molecular level. It discusses the use of nanomedicine techniques and theranostic nanomedicine for mitochondrial targeting, as well as the conceptual information on mitochondrial biomarkers for cancer treatment. The article also addresses the major drawbacks and challenges related to mitochondrial targeting for advanced cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Nidhi Goswami, Archana Singh, Shiv Bharadwaj, Amaresh Kumar Sahoo, Indrakant K. Singh
Summary: Neuroblastoma is a challenging tumor to develop drugs for due to its heterogeneity. ALYREF protein has been identified as a target for neuroblastoma treatment, and this study used structure-based drug discovery to find potential inhibitors. The study suggests further evaluation of these compounds for development of a drug against neuroblastoma.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Francesca Roda, Riccardo Caraffi, Silvia Picciolini, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Marzia Bedoni, Ilaria Ottonelli, Jason Thomas Duskey
Summary: Nanoparticles have potential as a strategy to improve the treatment of glioblastoma by enhancing drug delivery and targeting specific receptors or pathways. This review explores the latest strategies for drug delivery to glioblastoma, with a focus on the importance of surface functionalization for blood-brain barrier crossing and tumor specific targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rie Kuroda, Hiroshi Wakabayashi, Raita Araki, Anri Inaki, Ryosei Nishimura, Yasuhiro Ikawa, Kenichi Yoshimura, Toshinori Murayama, Yasuhito Imai, Tatsuyoshi Funasaka, Taizo Wada, Seigo Kinuya
Summary: In patients with high-risk neuroblastoma, the treatment regimen of I-131-mIBG therapy, single high-dose chemotherapy, and autologous or allogeneic stem cell transplantation is safe and effective without dose-limiting toxicity. Evaluations based on RECIST 1.1 showed stability disease and complete response rates of 87.5% and 12.5%, respectively.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Pharmacology & Pharmacy
Antonio J. Lopez Quinones, Leticia Salvador Vieira, Joanne Wang
Summary: This article focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response, and toxicity. Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131I-mIBG while minimizing toxicity in normal tissues.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Chemistry, Multidisciplinary
Dengfeng Zou, Aolin Zhang, Jianjiao Chen, Zhiqiang Chen, Jun Deng, Gang Li, Shunlin Zhang, Zhe Feng, Jingfei Feng, Jie Yang
Summary: Developing intelligent photosensitizers that respond to the tumor microenvironment is crucial for maximizing therapeutic efficacy and minimizing side effects in tumor phototherapy. This study presents the design and synthesis of a novel photosensitizer, BDPIN, with high singlet oxygen quantum yield and low dark toxicity, demonstrating its potential for enhanced phototherapy with lysosome targeting ability and excellent biosafety in both in vitro and in vivo studies.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Pharmacology & Pharmacy
Rebeca Burgos-Panadero, Souhaila H. El Moukhtari, Inmaculada Noguera, Carlos Rodriguez-Nogales, Susana Martin-Vano, Pablo Vicente-Munuera, Adela Canete, Samuel Navarro, Maria J. Blanco-Prieto, Rosa Noguera
Summary: Treatment of high-risk neuroblastoma is challenging due to metastases and drug resistance. This study found that the interaction between vitronectin and its ligands is related to the stiffness of the extracellular matrix in high-risk neuroblastoma, providing insights for targeting tumor cells within altered matrices using nanomedicine and combination therapy. Synergistic effects were observed between etoposide and cilengitide in increasing efficacy against neuroblastoma cells within these altered matrices.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Jinhui Gao, Claire Fosbrook, Jane Gibson, Timothy J. Underwood, Juliet C. Gray, Zoe S. Walters
Summary: Neuroblastoma is a common pediatric tumor with high mortality rates. Current treatments have limited success and relapse is common. EZH2, a histone methyltransferase, is overexpressed in neuroblastoma and promotes tumorigenesis and cell proliferation. Targeting EZH2 shows promise as a potential therapeutic approach for neuroblastoma.
CANCER TREATMENT REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Ozlem Ozen Karakus, Kavitha Godugu, Taher Salaheldin, Kazutoshi Fujioka, Shaker A. Mousa
Summary: The study synthesized nanoparticles targeting neuroblastoma by encapsulating chemotherapy agent paclitaxel, showing higher concentration in tumors. This supports targeted delivery of paclitaxel as a chemotherapeutic agent for neuroblastoma.
Article
Engineering, Biomedical
Sandra Sanchez-Salcedo, Ana Garcia, Adela Gonzalez-Jimenez, Maria Vallet-Regi
Summary: The development of biomaterials with high bioactivity and antibacterial properties for bone tissue regeneration is investigated. Nanocomposites of mesoporous bioactive glasses doped with silver nanoparticles were synthesized and used to fabricate three-dimensional scaffolds. The presence of silver nanoparticles inhibited bacterial growth and showed potential applications in bone tissue regeneration. The innovative methodology combined the sol-gel method and rapid prototyping technique.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Jorge Parra-Nieto, Maria Amor Garcia del Cid, Carolina Galeano, Inigo Aguirre de Carcer, Lorena Garcia-Garcia, Africa Gonzalez-Murillo, Diego Megias, Manuel Ramirez, Alejandro Baeza
Summary: This study reports the development of a multifunctional nanoplatform based on the assembly of protocells and polymeric nanocapsules, which can deliver cytotoxic drugs and enzymes to specific tumor tissues, effectively improving therapeutic outcomes. The nanoplatform exhibited significantly higher cytotoxic activity in neuroblastoma cells.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Engineering, Biomedical
Carla Jimenez-Jimenez, Almudena Moreno-Borrallo, Bianca Dumontel, Miguel Manzano, Maria Vallet-Regi
Summary: Nanotechnology has revolutionized potential disease treatments, but immune clearance and poor biocompatibility limit the use of nanoparticles for drug delivery. Coating nanoparticles with cell membranes is a hypothesis to overcome rejection and enhance biocompatibility. Here, we show that coating mesoporous silica nanoparticles with membranes from preosteoblastic cells can be used for potential bone disease treatments. Our results demonstrate the cellular selectivity and migration capability of camouflaged nanocarriers, which inspire future treatments.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Miguel Gisbert-Garzaran, Maria Natividad Gomez-Cerezo, Maria Vallet-Regi
Summary: Bone diseases have become a global public concern, affecting millions of people. Although current treatments are effective, they come with side effects. To address this, the development of biocompatible nanoparticles and macroscopic scaffolds has shown promise in improving bone regeneration while reducing side effects. This review highlights the emerging trend of materials that specifically recognize agents in the bone microenvironment, showcasing examples of modified nanoparticles and scaffolds. The potential of these bone-targeting agents to revolutionize the treatment of bone-related diseases is discussed, providing a comprehensive overview of the field's state-of-the-art.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Bianca Dumontel, Veronica Conejo-Rodriguez, Maria Vallet-Regi, Miguel Manzano
Summary: In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with responsive pore gatekeepers has shown potential for drug delivery systems (DDS) with controlled release. The use of natural biopolymers as smart materials in drug delivery applications has been investigated extensively. This review summarizes the coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs have shown promising therapeutic outcomes and potential for selective treatment of various diseases.
Article
Pharmacology & Pharmacy
Ana Arenas-Vivo, Vanessa Celis Arias, Georgiana Amariei, Roberto Rosal, Isabel Izquierdo-Barba, Tania Hidalgo, Maria Vallet-Regi, Hiram I. Beltran, Sandra Loera-Serna, Patricia Horcajada
Summary: Surface microbial colonization and biofilm formation are major problems causing human infectious diseases, and traditional treatments are often ineffective in eliminating biofilms. This study presents a silver-based metal-organic framework (AgBDC) that has antifouling properties and can prevent bacterial adhesion and surface contamination.
Review
Pharmacology & Pharmacy
Maria Vallet-Regi, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, Sonia Fiorilli
Summary: Mesoporous bioactive glasses (MBGs) are highly promising candidates in the field of bioceramics for bone tissue regeneration, thanks to their unique chemical composition, structural and surface properties. Recent research has focused on optimizing the texture and structure of MBGs and exploring their potential as multitherapy systems, particularly in the context of local drug delivery. This article provides an overview of the latest developments in MBGs for bone tissue engineering, multifunctionalization, and drug delivery, as well as discussing the current challenges and future directions for clinical translation of MBGs.
Article
Materials Science, Multidisciplinary
Rim Bouhajeb, Ana Cristina Abreu, Salima Selmi, Christoph Gerke, Ahlem Bellalah, Alexis Alvear-Jimenez, Laura Lozano Chamizo, Marzia Marciello, Gonzalo Villaverde, Ana Isabel Tristan, Leila Chekir-Ghedira, Ignacio Fernandez, Rafael Contreras-Caceres
Summary: We have developed an implantable dressing material made of electrospun poly(lactic acid) nanofibers containing the hydroethanolic extract of T. ramosissimum. The material showed improved wound-healing capabilities, reduced injury area, and high wound closure percentage in in vivo experiments on mice. The chemical structures of the main released compounds were identified using nuclear magnetic resonance.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Analytical
Guillermo Aragoneses-Cazorla, Maria Vallet-Regi, Ma. Milagros Gomez-Gomez, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: A combination of transcriptomics and metabolomics was used to study the mechanisms behind the antitumor action of a nanosystem called Ag@MSNs-Tf. Transcriptomics analysis was done using gene microarrays and RT-qPCR, while metabolomics analysis was done using high-resolution mass spectrometry. This multiomics approach revealed the impact of the nanosystem on various molecular pathways, including glycolysis, the pentose phosphate pathway, oxidative phosphorylation, and fatty acid synthesis.
Review
Chemistry, Multidisciplinary
Daniel Lozano, Vicente Larraga, Maria Vallet-Regi, Miguel Manzano
Summary: Vaccines are a major advancement in public health, preventing illness and death in millions of people each year. The use of nanotechnology has revolutionized vaccine development, with nanoparticles emerging as promising carriers for future vaccines. Despite significant progress in nanoparticle vaccine research, only a few have advanced to clinical investigation and usage so far.
Article
Pharmacology & Pharmacy
Daniel Lozano, Beatriz Leiva, Ines S. Gomez-Escalonilla, Sergio Portal-Nunez, Arancha R. de Gortazar, Miguel Manzano, Maria Vallet-Regi
Summary: Osteoporosis is commonly treated with antiresorptive drugs and anabolic agents, but these treatments have limitations. Pleiotrophin (PTN), a protein involved in tissue repair, and mesoporous silica nanoparticles (MSNs), a drug-delivery system, have shown potential for improving bone regeneration. In this study, PTN-loaded MSNs significantly enhanced osteogenesis and osteoblast differentiation when tested on MC3T3-E1 cells and human mesenchymal stem cells. This proof of concept suggests that MSNs can effectively deliver PTN and may be a promising treatment for osteoporosis and bone-regeneration scenarios.
Article
Polymer Science
Jesus L. Pablos, Javier Jimenez-Holguin, Sandra Sanchez Salcedo, Antonio J. Salinas, Teresa Corrales, Maria Vallet-Regi
Summary: The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization.
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Laura Casarrubios, Monica Cicuendez, Maria Vallet-Regi, Maria Teresa Portoles, Daniel Arcos, Maria Jose Feito
Summary: Bioactive mesoporous glass nanospheres (nanoMBGs) loaded with ipriflavone can produce positive immune effects, which have great potential for the treatment of osteoporosis and fracture prevention.
Article
Engineering, Biomedical
Bianca Dumontel, Carla Jimenez-Jimenez, Maria Vallet-Regi, Miguel Manzano
Summary: The integration of artificial nanoplatforms with natural bio-materials has led to the development of more efficient drug delivery systems. In this study, mesoporous silica nanoparticles (MSNs) were combined with tumor derived extracellular vesicles (EVs) to create a hybrid nanosystem that showed selective cellular internalization and enhanced intracellular drug accumulation, making it a promising candidate for targeted treatments.
MATERIALS TODAY BIO
(2023)
