Review
Biochemistry & Molecular Biology
Petr Vanek, Ondrej Urban, Vincent Zoundjiekpon, Premysl Falt
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with low survival rate. Early detection through pancreatic screening is crucial for improving survival. Systematic surveillance in high-risk individuals has shown benefits.
Review
Oncology
Linh-Huyen Truong, Siim Pauklin
Summary: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with no effective treatment currently available. The complexity and dynamics of the tumor microenvironment (TME) play a crucial role in PDAC treatment resistance, emphasizing the need for a detailed understanding of the TME. Insights into the heterogeneous TME composition and interplay among its components are essential for developing more efficient therapeutic approaches for PDAC.
Review
Biochemistry & Molecular Biology
Lokender Kumar, Sanjay Kumar, Kumar Sandeep, Sanjay Kumar Singh Patel
Summary: Cancer poses a significant challenge for effective treatment due to its complex mechanism, different stages of progression, and lack of screening and identification procedures. Pancreatic cancer, with a low survival rate of around 5 years, is ranked seventh globally among mortality-associated cancers. Therefore, it is crucial to develop diagnostic procedures for early detection, understand pancreatic cancer mechanisms, and explore therapeutic strategies. This review highlights recent developments in pancreatic cancer progression, mechanisms, and therapeutic approaches, including molecular techniques and biomedicines for effective cancer treatment.
Review
Pharmacology & Pharmacy
Min Ju Kim, Hyeyoun Chang, Gihoon Nam, Youngji Ko, Sun Hwa Kim, Thomas M. Roberts, Ju Hee Ryu
Summary: Pancreatic cancer, predicted to be the second leading cause of cancer-associated death by 2025, remains a lethal form of cancer with low patient survival rates. RNA interference (RNAi) has emerged as a promising approach for pancreatic cancer treatment, with the use of nanocarriers to overcome delivery challenges. Studies have shown that targeting either the tumor or tumor microenvironment using siRNA and miRNA can induce a strong anticancer effect in pancreatic cancer models.
Review
Gastroenterology & Hepatology
Laura D. Wood, Marcia Irene Canto, Elizabeth M. Jaffee, Diane M. Simeone
Summary: This review discusses the pathogenesis, early detection methods, and treatment considerations of pancreatic ductal adenocarcinoma (PDAC). Recent advances in understanding PDAC have led to significant improvements in detection and treatment, but coordinated efforts are needed to maximize clinical impact for patients and overall survival.
Review
Oncology
Krzysztof Szymonski, Katarzyna Milian-Ciesielska, Ewelina Lipiec, Dariusz Adamek
Summary: Pancreatic cancer is a highly aggressive and lethal malignancy, with ongoing uncertainty in pathological evaluation. Staying up-to-date with new research findings is crucial for clinicians and pathologists.
Review
Immunology
Khadijeh Barzaman, Shima Moradi-Kalbolandi, Aysooda Hosseinzadeh, Mohammad Hossein Kazemi, Hossein Khorramdelazad, Elahe Safari, Leila Farahmand
Summary: The study emphasizes the crucial role of the immune system in breast cancer treatment, and discusses the importance of using various immunotherapy methods in conjunction with traditional chemotherapy to improve patient survival rates, while pointing out the obstacles that still need to be addressed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Emmanouil Kalampokas, Georgios Giannis, Theodoros Kalampokas, Angeliki-Astero Papathanasiou, Dimitra Mitsopoulou, Evangelia Tsironi, Olga Triantafyllidou, Mahalakshmi Gurumurthy, David E. Parkin, Mary Cairns, Nikolaos F. Vlahos
Summary: This review aims to evaluate and present new perspectives and ongoing developments in the management of endometrial cancer, with a focus on the application of minimally invasive surgery and Sentinel lymph node biopsy (SLNB) in treatment strategies. After reviewing literature data, it was found that minimally invasive surgery has become the preferred surgical approach, and SLNB plays an important role in the management of both low-risk and high-risk endometrial cancer.
Review
Surgery
Marek Olakowski, Ewa Grudzinska
Summary: Pancreatic head cancer is a highly fatal disease, but surgery has shown potential for long-term cure with a 5-year survival rate of 30% after resection and adjuvant chemotherapy. This paper presents current data on lymphadenectomy, resection margin, resectable tumors, and surgical techniques to improve pancreaticoduodenectomy.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Veterinary Sciences
Diana Araujo, Ines Cabral, Nuno Vale, Irina Amorim
Summary: Gastric cancer is a prevalent cancer globally, but its impact differs between humans and dogs. Canine gastric cancer lacks significant attention in treatment, mainly due to its rapid progression and high mortality rate. Surgery is a common treatment option.
VETERINARY SCIENCES
(2022)
Review
Medicine, Research & Experimental
Nastazja Dagny Pilonis, Marc Tischkowitz, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: Hereditary diffuse gastric cancer (HDGC) is a rare cancer syndrome associated with significant risks of gastric and lobular breast cancer, often presenting late in clinical settings. While most cases can be traced back to germline variants in the CDH1 gene, some families with clustering of DGC do not have a clear genetic cause. This review focuses on discussing key elements for assessing inherited DGC susceptibility, providing practical recommendations for surveillance and treatment of at-risk individuals and early-stage patients.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Cardiac & Cardiovascular Systems
Angelo Giuseppe Caponetti, Antonella Accietto, Giulia Saturi, Alberto Ponziani, Maurizio Sguazzotti, Paolo Massa, Alessandro Giovannetti, Raffaello Ditaranto, Vanda Parisi, Ornella Leone, Pietro Guaraldi, Pietro Cortelli, Christian Gagliardi, Simone Longhi, Nazzareno Galie, Elena Biagini
Summary: Cardiac amyloidosis is a serious disease characterized by amyloid fibril deposition in the heart. Improved awareness has led to an increased diagnosis rate, especially in specific clinical settings. Identifying red flags and utilizing multimodality approaches, including PET fluorine tracers and artificial intelligence, can aid in early detection of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Kazuya Matsumoto, Yoshinori Kushiyama, Akio Izumi, Koji Ohnishi, Masahiko Miura, Yasufumi Ohuchi, Ikuko Hori, Tomonori Nakamura, Kotaro Hori, Kenji Koshino, Junko Kobayashi, Nagisa Yoshino, Ushio Hoshino, Takekiyo Okumura, Takashi Tanimura, Shinsuke Tanaka, Shino Tanaka, Tadashi Nabika, Tatsuaki Nozu, Yutaka Wakatsuki, Syunsuke Katayama, Shizue Yoshioka, Kenichi Ito, Akiko Uchida, Noriji Yuhara, Hisashi Noma, Hajime Isomoto
Summary: The establishment of the Pancreatic Cancer Project in Matsue can help improve the early detection rate and prognosis of pancreatic cancer, which is challenging to diagnose and treat.
Review
Oncology
Ravi G. Gupta, Fenge Li, Jason Roszik, Gregory Lizee
Summary: Immunotherapeutic manipulation targets genomic instability in cancer by activating T cells, but tumors can evade immune recognition through immunoediting and immunosuppressive mechanisms. Challenges in neoantigen-directed therapy include low frequency of immunogenic neoantigens and tumor cell immune evasion mechanisms.
Review
Oncology
Maciej Slodkowski, Marek Wronski, Dominika Karkocha, Leszek Kraj, Kaja Smigielska, Aneta Jachnis
Summary: Radical resection is the only curative treatment for pancreatic cancer, but only a small percentage of patients are eligible for surgery. Different surgical strategies and personalized treatments are being studied and compared to improve clinical outcomes. Careful selection based on tumor biology and other factors plays a key role in improving survival rates.
Article
Oncology
Brenda Y. Hernandez, Xuemei Zhu, Harvey A. Risch, Lingeng Lu, Xiaomei Ma, Melinda L. Irwin, Joseph K. Lim, Tamar H. Taddei, Karen S. Pawlish, Antoinette M. Stroup, Robert Brown, Zhanwei Wang, Linda L. Wong, Herbert Yu
Summary: This study found that the oral microbiome, particularly the presence of Cyanobacteria, plays an important role in the development of liver cancer. The presence of Cyanobacteria may be an independent risk factor for HCC. These findings support further research to explore the causal relationship between oral Cyanobacteria and HCC risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Biochemistry & Molecular Biology
Xinyi Shen, Yuping Cai, Lingeng Lu, Huang Huang, Hong Yan, Philip B. Paty, Engjel Muca, Nita Ahuja, Yawei Zhang, Caroline H. Johnson, Sajid A. Khan
Summary: This study explores the impact of tumor metabolome and sex on the prognosis of colorectal cancer patients. It reveals that the metabolites asparagine and serine have interactions with sex and are associated with poor survival rates and increased risk of recurrence in female patients. Additionally, lysophospholipid and polyamine synthesis also have negative prognostic effects on females. These findings provide insights for precision medicine in colorectal cancer treatment stratified by sex.
Article
Oncology
Christina M. Dieli-Conwright, Maura Harrigan, Brenda Cartmel, Anees Chagpar, Yalai Bai, Fang-yong Li, David L. Rimm, Lajos Pusztai, Lingeng Lu, Tara Sanft, Melinda L. Irwin
Summary: This study examined the impact of a 6-month weight loss intervention on breast tissue and serum biomarkers in women with breast cancer, and found that weight loss had favorable effects on metabolic and inflammatory markers associated with breast cancer.
Article
Oncology
Rui Han, Hongxing Yang, Changquan Ling, Lingeng Lu
Summary: This study explored the potential of Neurospora crassa as an anti-tumor agent against breast cancer. The results showed that a mixture of N. crassa significantly inhibited tumor cell proliferation, migration, invasion, and 3D spheroid formation. It also downregulated the expressions of cancer stem cell-related genes and transcription factors, while promoting apoptosis.
Article
Psychology, Clinical
Xiangzhi Jing, Hongling Meng, Yuping Li, Lingeng Lu, Yongcheng Yao
Summary: The study found that psychological capital and coping style modified the effect of emotional intelligence on health status in college students during the COVID-19 pandemic. It is recommended to implement comprehensive intervention measures, including positive coping styles, optimistic emotional perception and understanding, as well as social support.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Oncology
Rui Han, Hongxing Yang, Changquan Ling, Lingeng Lu
Summary: In this study, the therapeutic potential of Tiliroside (TS) in triple negative breast cancer (TNBC) was evaluated. The results showed that TS exhibited anti-cancer activity, reduced tumor burden, and improved survival rate in TNBC. Additionally, TS acted as a CAXII inhibitor to suppress TNBC progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Joy Shi, Peter Kraft, Bernard A. Rosner, Yolanda Benavente, Amanda Black, Louise A. Brinton, Chu Chen, Megan A. Clarke, Linda S. Cook, Laura Costas, Luigino Dal Maso, Jo L. Freudenheim, Jon Frias-Gomez, Christine M. Friedenreich, Montserrat Garcia-Closas, Marc T. Goodman, Lisa Johnson, Carlo La Vecchia, Fabio Levi, Jolanta Lissowska, Lingeng Lu, Susan E. McCann, Kirsten B. Moysich, Eva Negri, Kelli O'Connell, Fabio Parazzini, Stacey Petruzella, Jerry Polesel, Jeanette Ponte, Timothy R. Rebbeck, Peggy Reynolds, Fulvio Ricceri, Harvey A. Risch, Carlotta Sacerdote, Veronica W. Setiawan, Xiao-Ou Shu, Amanda B. Spurdle, Britton Trabert, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Wang Hong Xu, Hannah P. Yang, Herbert Yu, Mengmeng Du, Immaculata De Vivo
Summary: To mitigate the burden of endometrial cancer, risk stratification can help target interventions. The study developed risk prediction models using data from postmenopausal White women aged 45-85 years. The models based on epidemiologic factors alone successfully identified women at high risk of endometrial cancer, with limited improvements from genetic factors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Oncology
Huiling Zhou, Wentao Jia, Lingeng Lu, Rui Han
Summary: Based on the latest research, immune checkpoint inhibitors (ICIs) show promise in treating breast cancer. To enhance the curative effect, a new combined strategy is proposed by adding miRNA therapy into immune checkpoint blockade (ICB), as miRNAs targeting multiple immune checkpoint molecules can enhance the efficacy of ICB by mimicking combination therapy. Potential miRNAs have been summarized and potential side-effects and solutions have been discussed in this study. Evaluating the role of miRNAs with multiple immune checkpoint molecules in future research can further improve cancer immunotherapy.
Article
Immunology
Lingeng Lu, Evan Risch, Ruth Halaban, Pinyi Zhen, Antonella Bacchiocchi, Harvey A. Risch
Summary: The dynamic changes of circulating soluble PD-1 and PD-L1, as well as their ratios, during immune checkpoint blockade treatment in melanoma patients reflect the patients' response to the treatment and can predict survival. An increase in soluble PD-L1 level at a certain time point significantly increases mortality, while an increase in soluble PD-1/PD-L1 ratio significantly reduces mortality. These findings suggest that monitoring the changes in circulating soluble PD-1 and PD-L1 levels over time can provide valuable information for the management of melanoma patients treated with immune checkpoint blockades.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Lingeng Lu, Wenxue Ma, Caroline H. Johnson, Sajid A. Khan, Melinda L. Irwin, Lajos Pusztai
Summary: Somatic mutation-derived neoantigens are used to develop an mRNA vaccine targeting CA-125 neoantigen for breast and ovarian cancer. Immuno-bioinformatics tools were used to predict CD8' T cell epitopes and a self-adjuvant mRNA vaccine was constructed to enhance cross-presentation by dendritic cells. Immune responses post-immunization were estimated using an in silico algorithm, showing IFN-c and CD8' T cell response. The strategy described in this study can be used to design precision multi-epitope mRNA vaccines targeting multiple neoantigens.
Article
Biochemistry & Molecular Biology
Ningshan Li, Siqiong Yao, Guangjun Yu, Lingeng Lu, Zuoheng Wang
Summary: tRFtarget 2.0 is a platform that consolidates high-quality tRF sequences and binding sites with target genes across multiple organisms. It introduces new features and improvements for a more comprehensive and user-friendly research platform.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Nutrition & Dietetics
Yuqian Wang, Lingeng Lu, Changquan Ling, Ping Zhang, Rui Han
Summary: This study proposes a novel therapeutic strategy for breast cancer treatment by combining a diet containing HDAC2 inhibitors with PD-1/PD-L1 inhibitors, offering promising possibilities for improving treatment outcomes.
Article
Psychology, Multidisciplinary
Yongcheng Yao, Junyan Yao, Shuyan Chen, Xiaohui Zhang, Hongling Meng, Yuping Li, Lingeng Lu
Summary: This study examined the association between self-reported health status, depressive tendency, psychological capital, and self-acceptance of college students in China during the COVID-19 pandemic. The results showed that male college students had higher depressive tendency scores than females, and college students without siblings had higher psychological capital scores than those with siblings. Exercise had positive associations with health status, psychological capital, and self-acceptance, while online time per day had negative associations. Psychological capital and self-acceptance modified the association between depressive tendency and health status.
BEHAVIORAL SCIENCES
(2023)
Article
Oncology
Tianhao Shan, Xianhui Ran, Huizhang Li, Guoshuang Feng, Siwei Zhang, Xuehong Zhang, Lei Zhang, Lingeng Lu, Lan An, Ruiying Fu, Kexin Sun, Shaoming Wang, Ru Chen, Li Li, Wanqing Chen, Wenqiang Wei, Hongmei Zeng, Jie He
Summary: This study reveals disparities in the stage of liver cancer diagnosis among different populations in China, with higher proportions of advanced stage (III-IV) cases in women, patients aged 60 and above, drinkers, and those without a family history of cancer. Furthermore, the stage distribution in China is significantly higher than that in the USA.
JOURNAL OF THE NATIONAL CANCER CENTER
(2023)
Review
Oncology
Liqin Yao, Gang Jia, Lingeng Lu, Wenxue Ma
Summary: Neoadjuvant chemotherapy (NACT) aims to shrink tumors or prevent cancer cell spread before surgery in breast cancer patients. However, not all patients benefit from NACT, and molecular testing can help identify which patients will benefit from this treatment.
