The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy

(2018) Allie J. Widman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization

(2017) Nathan G. Glasgow et al.   JOURNAL OF NEUROSCIENCE

Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression

(2017) F Hieronymus et al.   MOLECULAR PSYCHIATRY

Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties

(2017) Heather Kang et al.   NEUROPHARMACOLOGY

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

(2016) Ambalika Sarkar et al.   BIOLOGICAL PSYCHIATRY

Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling

(2016) Eléonore Beurel et al.   BIPOLAR DISORDERS

The antidepressant effect of ketamine: Mediated by AMPA receptors?

(2016) Dragos Inta et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

GluA4 subunit of AMPA receptors mediates the early synaptic response to altered network activity in the developing hippocampus

(2016) J. Huupponen et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

(2016) Oliver H. Miller et al.   NEUROPHARMACOLOGY

Ketamine Affects the Neurogenesis of the Hippocampal Dentate Gyrus in 7-Day-Old Rats

(2016) He Huang et al.   NEUROTOXICITY RESEARCH

A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life

(2016) Kuen-Jer Tsai et al.   PLoS One

Ketamine Inside Neurons?

(2015) Henry A. Lester et al.   AMERICAN JOURNAL OF PSYCHIATRY

Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing

(2015) Samuel Fanta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Tonically active NMDA receptors - a signalling mechanism critical for interneuronal excitability in the CA1 stratum radiatum

(2015) Ilse Riebe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of the nitric oxide donor sodium nitroprusside in the antidepressant effect of ketamine in mice

(2015) Miriam A. Vogt et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats

(2015) Oliver Grimm et al.   PSYCHOPHARMACOLOGY

(R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function

(2014) Rajib K. Paul et al.   ANESTHESIOLOGY

Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice

(2014) Rachel J. Donahue et al.   BIOLOGICAL PSYCHIATRY

Ketamine Inhibits Proliferation of Neural Stem Cell from Neonatal Rat Hippocampusin Vitro

(2014) Yu-Qing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neonatal glucocorticoid treatment increased depression-like behaviour in adult rats

(2014) Meng-Chang Ko et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Functional organization of the hippocampal longitudinal axis

(2014) Bryan A. Strange et al.   NATURE REVIEWS NEUROSCIENCE

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

(2014) Laura Pozzi et al.   PLoS One

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

(2014) E. S. Gideons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

NMDA receptor antagonists ketamine and Ro25-6981 inhibit evoked release of glutamate in vivo in the subiculum

(2014) T L Stan et al.   Translational Psychiatry

Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade

(2014) Elena Nosyreva et al.   Frontiers in Molecular Neuroscience

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims

(2013) Magdalena Sowa-Kućma et al.   JOURNAL OF AFFECTIVE DISORDERS

Ketamine regulates the presynaptic release machinery in the hippocampus

(2013) Heidi Kaastrup Müller et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups

(2013) Chun-I Sze et al.   MEDIATORS OF INFLAMMATION

Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

(2013) G Sanacora et al.   MOLECULAR PSYCHIATRY

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

(2013) J Iafrati et al.   MOLECULAR PSYCHIATRY

AMPA-silent synapses in brain development and pathology

(2013) Eric Hanse et al.   NATURE REVIEWS NEUROSCIENCE

Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure

(2013) Su-Xia Li et al.   NEUROBIOLOGY OF DISEASE

Sub-Anesthetic Ketamine Modulates Intrinsic BOLD Connectivity Within the Hippocampal-Prefrontal Circuit in the Rat

(2013) Natalia Gass et al.   NEUROPSYCHOPHARMACOLOGY

Neurogenesis along the septo-temporal axis of the hippocampus: Are depression and the action of antidepressants region-specific?

(2013) A. Tanti et al.   NEUROSCIENCE

The blockade of NMDA receptor ion channels by ketamine is enhanced in developing rat cortical neurons

(2013) Jianhui Jin et al.   NEUROSCIENCE LETTERS

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Prenatal Stress Inhibits Hippocampal Neurogenesis but Spares Olfactory Bulb Neurogenesis

(2013) Laure Belnoue et al.   PLoS One

Reduced Levels of NR1 and NR2A with Depression-Like Behavior in Different Brain Regions in Prenatally Stressed Juvenile Offspring

(2013) Hongli Sun et al.   PLoS One

Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects

(2012) Henry A. Lester et al.   BIOLOGICAL PSYCHIATRY

A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus

(2012) Michael A Bonaguidi et al.   CURRENT OPINION IN NEUROBIOLOGY

Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

(2012) Ruin Moaddel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus

(2012) Arnaud Tanti et al.   NEUROPHARMACOLOGY

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

(2012) R. S. Duman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Stress-Induced Changes of Hippocampal NMDA Receptors: Modulation by Duloxetine Treatment

(2012) Francesca Calabrese et al.   PLoS One

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus

(2011) S. A. Neymotin et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood

(2010) Mazen A Kheirbek et al.   NEUROPSYCHOPHARMACOLOGY

Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats

(2010) Kimihiko Watanabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action☆

(2009) P.J. Lucassen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Direct and dam-mediated effects of prenatal dexamethasone on emotionality, cognition and HPA axis in adult Wistar rats

(2009) Jonas Hauser et al.   HORMONES AND BEHAVIOR

Reduced platelet BDNF level in patients with major depression

(2009) Bun-Hee Lee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Prenatal Dexamethasone Impairs Behavior and the Activation of the BDNF Exon IV Promoter in the Paraventricular Nucleus in Adult Offspring

(2008) Amzad Hossain et al.   ENDOCRINOLOGY

Effects of sub-anesthetic doses of ketamine on rats' spatial and non-spatial recognition memory

(2008) N. Pitsikas et al.   NEUROSCIENCE

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age-dependent manner

(2007) Masatoshi Nagano et al.   NEUROSCIENCE RESEARCH