Review
Oncology
Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez, Jose-Tomas Navarro
Summary: Epstein-Barr virus (EBV) plays a role in lymphomagenesis, particularly in populations with immunodeficiencies like people living with HIV (PLWH). The presence of EBV in these lymphomas affects their epidemiological, pathological, and clinical characteristics, as well as their prognosis. EBV, along with cooperation with HIV, mediates the pathogenic roles in lymphomas arising in PLWH.
Article
Immunology
Julien Lupo, Raphaele Germi, Remi Lancar, Michele Algarte-Genin, Houria Hendel-Chavez, Yassine Taoufik, Nicolas Mounier, Marialuisa Partisani, Fabrice Bonnet, Marie-Caroline Meyohas, Bruno Marchou, Anastasiia Filippova, Sophie Prevot, Dominique Costagliola, Patrice Morand, Caroline Besson
Summary: In the modern cART era, the EBV DNA load in whole blood and plasma at NHL diagnosis does not serve as prognostic markers for HIV-NHL patients.
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Chun-Xu Liao, Chang-Song Deng, Xia Liang, Jian-Chuan Yang, Zhi-Zhong Chen, Xiao-Ying Lin, Cai-Feng Lin, Shen Chen, Song-Song Wu
Summary: This study presents a case of advanced intrahepatic cholangiocarcinoma (ICC) treated with a combination of immunotherapy and radiotherapy, resulting in complete remission and prolonged progression-free survival. The findings suggest that the combination of PD-1 inhibitors with radiotherapy may serve as a promising therapeutic strategy for treating this specific cancer subtype.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Masatoshi Ito, Kai Kudo, Hiroshi Higuchi, Hiroko Otsuka, Masayuki Tanaka, Nahoko Fukunishi, Takuma Araki, Masako Takamatsu, Yoko Ino, Yayoi Kimura, Ai Kotani
Summary: The study revealed that EVs derived from EBV-transformed lymphomas contain immunomodulatory proteins and phospholipids associated with TAM formation, which may contribute to the development of lymphomas.
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Ziyuan Shen, Lingling Hu, Mingkang Yao, Chenlu He, Qinhua Liu, Fei Wang, Weiying Gu, Ying Wang, Manyu Dong, Taigang Zhu, Ting Yin, Fei Li, Yingliang Jin, Shuiping Huang, Hao Zhang, Wei Sang
Summary: A retrospective multicenter study of 454 lymphoma patients found that elevated EBV DNA load can affect the prognosis of NKTL, FL, and DLBCL. The integration of EBER status and EBV DNA can differentiate the prognosis of HL patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Yan Pan, Linbin Lu, Huan Liu, Di Chen, Ning Han, Ruirong Yao, Xinlin Wang, Xianchun Gao, Jun Yu, Ling Chen, Fenli Zhou, Guangjun Hao, Yuanyuan Lu, Mengbin Li, Guangbin He, Fei Kang, Zengshan Li, Yongqiang Tang, Jinsong Zhang, Lichun Wei, Yongzhan Nie
Summary: Trastuzumab-containing chemotherapy is the standard first-line treatment for advanced gastric cancer (GC) with HER2 positive. However, few studies have explored the effectiveness of anti-PD-1 therapy in overcoming resistance to trastuzumab plus chemotherapy in advanced Epstein-Barr Virus-associated gastric cancer (EBVaGC) with PD-L1 and HER2 positive. In this case presentation, a 45-year-old man with advanced EBVaGC presented with fatigue, dysphagia, and weight loss. He received trastuzumab plus chemotherapy as first-line treatment, followed by nivolumab monotherapy, total radical gastrectomy plus sequential radiotherapy, and postoperative immunotherapy. The patient achieved a durable clinical benefit with a PFS of 28 months.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Chantana Polprasert, Yasuhide Takeuchi, Hideki Makishima, Kitsada Wudhikarn, Nobuyuki Kakiuchi, Nichthida Tangnuntachai, Thamathorn Assanasen, Wimonmas Sitthi, Hamidah Muhamad, Panisinee Lawasut, Sunisa Kongkiatkamon, Udomsak Bunworasate, Koji Lzutsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Kenichi Yoshida, Ponlapat Rojnuckarin
Summary: ENKTCLs are aggressive lymphomas predominantly affecting Asians. Defective HLA-A gene is recurrently identified in ENKTCLs and associated with disease progression, suggesting immune escape as a pathogenic mechanism.
LEUKEMIA & LYMPHOMA
(2021)
Article
Immunology
Tingting Cui, Jingshi Wang, Zhao Wang
Summary: This study aimed to build a model for predicting the risk of death during induction therapy in patients with Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (HLH). The study included 234 patients with EBV-HLH, of whom 65 (27.4%) died during induction therapy. A nomogram was developed to stratify patients into high-risk and low-risk groups with a high predictive accuracy. The high-risk patients had a significantly higher risk of death compared to the low-risk patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Huageng Huang, Yuyi Yao, Xinyi Deng, Zongyao Huang, Yungchang Chen, Zhao Wang, Huangming Hong, He Huang, Tongyu Lin
Summary: Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV) infection and conventional salvage treatments for advanced NPC have limited efficacy. Immunotherapy has emerged as a promising treatment modality for recurrent and metastatic NPC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Hao Zhou, Yuxiang He, Chunlin Ou, Xiaoyun He, Pengfei Cao
Summary: microRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that play important roles in cell processes and the development of various malignancies. The miR-18a is found to be involved in cancer development, but its role in lymphoma is not fully understood. In this study, we investigated the clinicopathological characteristics and potential functional roles of miR-18a in lymphomas. We identified potential downstream genes of miR-18a and found that the deletion of ATM and p53 genes downstream of miR-18a is closely associated with lymphoma development. These biomarkers may serve as key prognostic factors for lymphomas.
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
