Article
Immunology
Yves Carlier, Carine Truyens, Eric Muraille
Summary: This study discusses the potential role of antibody-dependent enhancement (ADE) in the trans-placental parasite transmission or the development of severe and fatal clinical forms of congenital/neonatal Chagas disease in newborns of T. cruzi-infected mothers. It highlights the importance of understanding how antibodies transmitted from infected pregnant women may influence the neonatal immune response to the parasite.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Erica Silberstein, Kwang Sik Kim, David Acosta, Alain Debrabant
Summary: This study utilized a 3D cell culture model to recreate the human placental environment, demonstrating that 3D-cultured JEG-3 cells have reduced susceptibility to T. cruzi infection and release paracrine factors that prevent infection of non-trophoblastic cell lines. This in vitro model may help understand how parasites bypass the human placental barrier and could be used to evaluate therapeutics for reducing congenital Chagas Disease.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Jill M. C. Hakim, Andreea Waltmann, Freddy Tinajeros, Oksana Kharabora, Edith Malaga Machaca, Maritza Calderon, Maria del Carmen Menduina, Jeremy Wang, Daniel Rueda, Mirko Zimic, Manuela Verastegui, Jonathan J. Juliano, Robert H. Gilman, Monica R. Mugnier, Natalie M. Bowman
Summary: Investigating the diversity of parasite strains in congenital Chagas infection, amplicon sequencing of a T. cruzi gene was conducted on clinical samples from Chagas positive mothers and their infected infants. The study found that multiple parasite strains are involved in initiating congenital infection, and the diversity of parasite strains is higher in infants than in mothers. These findings suggest that the probability of vertical transmission is influenced by parasite factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Eduardo E. Avalos-Borges, Lizette E. Rios, Matilde Jimenez-Coello, Antonio Ortega-Pacheco, Nisha J. Garg
Summary: This article reviews the current knowledge of congenital transmission of Trypanosoma cruzi in humans and compares the placental architecture of humans and different animals. This is important for evaluating the efficacy of new anti-parasite drugs and therapies.
Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Roy G. Stone, Patrick Gavin, Peter Chiodini, Debbie Nolder, Padraig McGettrick, Anna Keogh, Noel Mc Entagart, Richard Drew, Jack Lambert, Wendy Ferguson
Summary: This article discusses the observation of Chagas disease outside of Latin America and describes the first two infants with congenital Chagas Disease (cCD) in Ireland. It highlights the need for clinicians in non-endemic countries to be aware of the potential risk of cCD due to migration from high-prevalence countries.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Review
Microbiology
Alba Abras, Cristina Ballart, Anna Fernandez-Arevalo, Maria-Jesus Pinazo, Joaquim Gascon, Carmen Munoz, Montserrat Gallego
Summary: Population movements have made Chagas disease a global public health issue. Despite efforts to control transmission in Latin American countries where the disease is endemic, congenital Chagas disease remains a significant challenge.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Review
Infectious Diseases
Morven S. Edwards, Susan P. Montgomery
Summary: Recent updates from international organizations recommend diagnosis, treatment, and prevention strategies for congenital Chagas disease. Successful implementation of pregnancy-based screening at certain centers can serve as a model for improving diagnosis. Screening family members may help identify additional infected individuals.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araujo Souto, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Summary: Chagas disease is a long-standing disease that primarily affects impoverished populations in Latin America. The available drugs have limited effectiveness and intense side effects. This study explores the biological activity of two new series of pyrazole-thiazoline derivatives with potential therapeutic options against Trypanosoma cruzi. These derivatives show potent activity with good oral bioavailability and low cytotoxicity, making them potential candidates for Chagas disease therapy.
Article
Immunology
Izadora Volpato Rossi, Maria Alice Ferreira Nunes, Bruna Sabatke, Hennrique Taborda Ribas, Sheila Maria Brochado Winnischofer, Augusto Savio Peixoto Ramos, Jameel Malhador Inal, Marcel Ivan Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi, which uses blood-feeding triatomine bugs to infect mammalian hosts. The parasite needs to evade the complement system and quickly invade cells for infection, achieved through the expression of different molecules and release of extracellular vesicles (EVs). Selecting a population of T. cruzi after exposure to human serum stress factors can lead to increased metacyclogenesis, resistance to complement-mediated lysis, and greater infectivity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
A. Abras, C. Ballart, A. Fernandez-Arevalo, T. Llovet, M. Gallego, C. Munoz
Summary: The study evaluated two algorithms for the diagnosis of chronic and congenital Chagas disease, with CMIA showing potential as a single diagnostic test in non-endemic countries and the revised algorithm with the >= 6 S/CO proving to be an efficient method for chronic CD diagnosis. For infants with congenital infection, CMIA could potentially be used as a single test for screening at 10 months or earlier, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Microbiology
Amilcar Flores, Cristina Alonso-Vega, Emmanuel Hermann, Mary-Cruz Torrico, Nair Alaide Montano Villarroel, Faustino Torrico, Yves Carlier, Carine Truyens
Summary: Monocytes from newborns born to Trypanosoma cruzi infected mothers are more activated and capable of controlling T. cruzi infection better than monocytes from newborns born to uninfected mothers.
Article
Infectious Diseases
Indira Chakravarti, Monica Miranda-Schaeubinger, Adriana Ruiz-Remigio, Carlos Briones-Garduno, Edith A. Fernandez-Figueroa, Concepcion Celeste Villanueva-Cabello, Alejandra Borge-Villareal, Yadira Bejar-Ramirez, Alejandro Perez-Gonzalez, Cesar Rivera-Benitez, Eyal Oren, Heidi E. Brown, Ingeborg Becker, Robert H. Gilman
Summary: This study aimed to screen pregnant women from endemic areas for Trypanosoma cruzi infection and provide timely treatment for Chagas disease. Among 150 pregnant women, 20% tested positive, but only 6% were confirmed positive by PCR. Current diagnostic tests have limitations, and further evaluation of different assays may improve the diagnosis and management of Chagas disease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Entomology
Pablo L. Santo-Orihuela, Claudia V. Vassena, Guillermo Carvajal, Eva Clark, Silvio Menacho, Ricardo Bozo, Robert H. Gilman, Caryn Bern, Paula L. Marcet
JOURNAL OF MEDICAL ENTOMOLOGY
(2017)
Review
Parasitology
Mary M. Cameron, Alvaro Acosta-Serrano, Caryn Bern, Marleen Boelaert, Margriet den Boer, Sakib Burza, Lloyd A. C. Chapman, Alexandra Chaskopoulou, Michael Coleman, Orin Courtenay, Simon Croft, Pradeep Das, Erin Dilger, Geraldine Foster, Rajesh Garlapati, Lee Haines, Angela Harris, Janet Hemingway, T. Deirdre Hollingsworth, Sarah Jervis, Graham Medley, Michael Miles, Mark Paine, Albert Picado, Richard Poche, Paul Ready, Matthew Rogers, Mark Rowland, Shyam Sundar, Sake J. de Vlas, David Weetman
PARASITES & VECTORS
(2016)
Article
Infectious Diseases
Yagahira E. Castro-Sesquen, Robert H. Gilman, Carolina Mejia, Daniel E. Clark, Jeong Choi, Melissa J. Reimer-McAtee, Rosario Castro, Edward Valencia-Ayala, Jorge Flores, Natalie Bowman, Ricardo Castillo-Neyra, Faustino Torrico, Lance Liotta, Caryn Bern, Alessandra Luchini
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Immunology
Jason R. Andrews, Krista Vaidya, Caryn Bern, Dipesh Tamrakar, Shawn Wen, Surendra Madhup, Rajeev Shrestha, Biraj Karmacharya, Bibush Amatya, Rajendra Koju, Shiva Raj Adhikari, Elizabeth Hohmann, Edward T. Ryan, Isaac I. Bogoch
JOURNAL OF INFECTIOUS DISEASES
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Caryn Bern
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Article
Parasitology
Ariel Loza, Adrianna Talaga, Gladys Herbas, Ruben Jair Canaviri, Thalia Cahuasiri, Laura Luck, Alvaro Guibarra, Raquel Goncalves, Juan Antonio Pereira, Sonia A. Gomez, Albert Picado, Louisa Alexandra Messenger, Caryn Bern, Orin Courtenay
PARASITES & VECTORS
(2017)
Article
Parasitology
Katherine Yih-Jia Fu, Roxana Zamudio, Jo Henderson-Frost, Alex Almuedo, Hannah Steinberg, Steven Joseph Clipman, Gustavo Duran, Rachel Marcus, Thomas Crawford, Daniel Alyesh, Rony Colanzi, Jorge Flores, Robert Hugh Gilman, Caryn Bern
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2017)
Review
Microbiology
Orin Courtenay, Nathan C. Peters, Matthew E. Rogers, Caryn Bern
Article
Immunology
Tapan Bhattacharyya, Louisa A. Messenger, Caryn Bern, Pascal Mertens, Quentin Gilleman, Nicolas Zeippen, Bruno C. Bremer Hinckel, Niamh Murphy, Robert H. Gilman, Michael A. Miles
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Cardiac & Cardiovascular Systems
Harry Acquatella, Federico M. Asch, Marcia M. Barbosa, Marcio Barros, Caryn Bern, Joao L. Cavalcante, Luis Eduardo Echeverria, Joao Lima, Rachel Marcus, Jose Antonio Marin-Neto, Ricardo Migliore, Jose Milei, Carlos A. Morillo, Maria Carmo Pereira Nunes, Marcelo Luiz Campos Vieira, Rodolfo Viotti
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2018)
Article
Multidisciplinary Sciences
Steven J. Clipman, Josephine Henderson-Frost, Katherine Y. Fu, Caryn Bern, Jorge Flores, Robert H. Gilman
Article
Infectious Diseases
Eva H. Clark, Caryn Bern
Summary: There are still many unanswered questions regarding Trypanosoma cruzi infection in people with HIV, with reported prevalence ranging from 1-28%. HIV-infected individuals are at risk for a severe and often fatal form of T. cruzi-mediated disease called reactivation disease, and early detection through screening at HIV diagnosis is critical for prevention.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Immunology
Gerardo J. Sanchez, Holger Mayta, Monica J. Pajuelo, Karen Neira, Liu Xiaofang, Lilia Cabrera, Sarah Blythe Ballard, Jean E. Crabtree, Dermot Kelleher, Vitaliano Cama, Caryn Bern, Hitoshi Oshitani, Robert H. Gilman, Mayuko Saito
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Immunology
Louisa A. Messenger, Robert H. Gilman, Manuela Verastegui, Gerson Galdos-Cardenas, Gerardo Sanchez, Edward Valencia, Leny Sanchez, Edith Malaga, Victoria R. Rendell, Malasa Jois, Vishal Shah, Nicole Santos, Maria Del Carmen Abastoflor, Carlos LaFuente, Rony Colanzi, Ricardo Bozo, Caryn Bern
CLINICAL INFECTIOUS DISEASES
(2017)
Article
Immunology
Ricardo Molina, Debashis Ghosh, Eugenia Carrillo, Severine Monnerat, Caryn Bern, Dinesh Mondal, Jorge Alvar
CLINICAL INFECTIOUS DISEASES
(2017)
